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  • Articles: DFG German National Licenses  (16)
  • 1995-1999  (8)
  • 1985-1989  (8)
  • 1999  (8)
  • 1986  (8)
  • 1
    Electronic Resource
    Electronic Resource
    3′,5′-Cyclic Guanosine Monophosphate Activates Mitogen-Activated Protein Kinase in Rat Pinealocytes (1999)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 73 (1999), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract : The role of 3′,5′-cyclic guanosine monophosphate (cGMP) in the activation of mitogen-activated protein kinases (MAPKs) was investigated in rat pinealocytes. Treatment with dibutyryl cGMP (DBcGMP) dosedependently increased the phosphorylation of both p44 and p42 isoforms of MAPK. This effect of DBcGMP was abolished by PD98059 (a MAPK kinase inhibitor), H7 (a nonspecific protein kinase inhibitor), and KT5823 [a selective cGMP-dependent protein kinase (PKG) inhibitor]. Elevation of cellular cGMP content by treatment with norepinephrine, zaprinast (a cGMP phosphodiesterase inhibitor), or nitroprusside was effective in activating MAPK. Natriuretic peptides that were effective in elevating cGMP levels in this tissue were also effective in activating MAPK. Our results indicate that, in this neuroendocrine tissue, the cGMP/PKG signaling pathway is an important mechanism used by hormones and neurotransmitters in activating MAPK.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1999.0730598.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The value of blood group-specific lectin and endothelial associated antibodies in the diagnosis of vascular proliferations (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 13 (1986), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Blood vascular and lymphatic tumors were evaluated immunohistochemically by studying a spectrum of endothelial associated antigens. (1) UEA-I lectin reacted with the tumor cells of one patient with malignant angioendothelioma in the non-metastatic stage. However, when metastasis occurred, the binding sites of this lectin completely disappeared from the surface of the tumor cells in both original and metastatic lesions, suggesting the loss of blood group H antigen from the tumor cells could be used as an indicator of metastasis in this tumor. (2) Reaction with anti-HLA-A, B, C, intense in normal blood vessels, remained intensely positive in pyogenic granuloma and Kaposi's sarcoma, whereas it did not react with normal lymphatics and lymphangioma. This indicates that anti-HLA-A, B, C is useful in differentiating blood vascular structures from lymphatic structures in both normal and pathological conditions. (3) OKM5 reacted intensely with benign hyperplasius in pyogenic granuloma, while barely reacting with proliferating parts in Kaposi's sarcoma, suggesting the difference in staining patterns can be used to distinguish vascular proliferation or malignancy. (4) Reaction with anti-Type IV collagen and anti-laminin was intense in normal blood vessels, pyogenic granuloma and Kaposi's sarcoma, whereas reaction with these antibodies in normal lymphatics was patchy and irregular in its thickness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1986.tb01084.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Variation of the distribution pattern of SH groups and SS linkages in the human epidermis (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 13 (1986), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Normal epidermis of various sites of human body was examined by N-(7-dimethyl-amino-4-methyl-3-coumarinyl)maleimidc (DACM) method for SH groups and SS linkages. The horny cells in the palm and sole showed a gradual occurrence of a SH membranous pattern, while those in other sites revealed an abrupt formation of the SH membranous pattern just above the granular layer. In the palm and sole epidermis the number of layers which exhibit membranous pattern of SH-positivity was thicker than that in the other epidermis; the low- through mid-layers of horny cells in the former sites seemed to contain not only SS-positive but also SH-positive substance at cell peripheries. The DACM staining for SS linkages showed the presence of a granular fluorescence in the cytoplasm of the granular cells of the epidermis in the human palm and sole, but not in other sites. The granular cells in human lip displayed a granular fluorescence in the cytoplasm by cither SH or SS DACM staining. All the SH- or SS-positive granular fluorescence was related to keratohyaline granules. These findings indicate that there may be some variations of the distribution pattern of the epidermal cellular proteins with SH and/or SS and a difference in chemical composition of keratohyaline granules between different anatomical sites of human body.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1986.tb01524.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Plasminogen activator secreted by cultured human melanocytes (1986)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 115 (1986), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A plasminogen activator (PA), Mr 72 000, was detected in conditioned medium from human melanocyte cultures by fibrin autography. The electrophoretic mobility was identical to that of tissue PA produced by Bowes melanoma cells. PA activity in human melanocyte culture medium was inhibited by anti-tissue PA IgG, but not by anti-urokinase IgG. Our results are the first to show that normal human melanocytes in culture secrete tissue plasminogen activator.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1986.tb05719.x
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  • 5
    Electronic Resource
    Electronic Resource
    Secretion of plasminogen activator inhibitor by cultured human epidermal cells (1986)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 115 (1986), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A conditioned medium from cultured human epidermal cells was observed to inhibit the activity of exogenous urokinase. By reverse fibrin autography after SDS polyacrylamide gel electrophoresis, a plasminogen activator inhibitor was detected with a molecular weight of 46000. Using Mr- 33000 [125I]-labelled urokinase we observed the formation of an enzyme-ligand complex. The molecular weight of this complex was 79000. These results indicate that cultured human epidermal cells secrete a plasminogen activator inhibitor (urokinase inhibitor) with a molecular weight of 46000.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1986.tb05708.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Anodically deposited manganese-molybdenum oxide anodes with high selectivity for evolving oxygen in electrolysis of seawater (1999)
    Springer
    Journal of applied electrochemistry 29 (1999), S. 769-775 
    Details
    ISSN: 1572-8838
    Keywords: anodic deposition ; manganese-molybdenum oxide electrode ; oxygen evolution ; seawater electrolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Manganese-molybdenum oxide electrodes were prepared by anodic deposition on an IrO2-coated titanium substrate at a constant current density of 600Am−2 from baths containing 0.2M MnSO4 and 0–0.1M Na2MoO4 at 90∘C and pH 0.5. These electrodes were characterised for oxygen evolution in the electrolysis at 1,000Am−2 in 0.5M NaCl solution at 30∘C and pH 8 or 12. The most active and stable oxygen evolving anode exhibited 100% efficiency for oxygen evolution, and an efficiency of 98.5% for over 1,500 h at pH 12 and of 96.5% for over 2,800 h at pH 8 of continuous electrolysis. X-ray diffraction measurement and XPS analysis indicated that the deposits consist of a nanocrystalline single γ-MnO2 type phase, and manganese and molybdenum in the deposits are in the Mn4+ and Mo6+ states. The electrochemical studies showed that the manganese-molybdenum oxide electrodes drastically reduced the electrocatalytic activity for chlorine evolution to the undetectable level, resulting in 100% efficiency for oxygen evolution, although the addition of molybdenum slightly increased the oxygen overpotential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003492009263
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  • 7
    Electronic Resource
    Electronic Resource
    Anodic characteristics of amorphorous palladium-base alloys in sodium chloride solutions (1986)
    Springer
    Journal of applied electrochemistry 16 (1986), S. 565-574 
    Details
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The anodic characteristics of a variety of amorphous palladium-base alloys were examined with a view to their use for the production of sodium hypochlorite by electrolysis of dilute sodium chloride solutions at ambient temperature. The corrosion resistance of palladium-metalloid alloys was obtained by alloying with platinum group metals and/or valve metals. Among these alloys, rhodium-containing alloys showed high electrocatalytic activities for chlorine evolution. Surface activation treatment was, however, necessary to obtain sufficiently high activities for chlorine evolution at low overpotentials. Surface-activated amorphous alloys possessed considerably higher current efficiency for chlorine evolution in comparison with currently used anodes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01006851
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  • 8
    Electronic Resource
    Electronic Resource
    Bioactive marine metabolites. VIII. Isolation of an antimicrobial blue pigment from the bryozoanBugula dentata (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 84-84 
    Details
    ISSN: 1420-9071
    Keywords: Bugula dentata ; bryozoa ; antimicrobial ; tetrapyrrole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An antimicrobial blue pigment, which is identical with a tetrapyrrole from a bacterium, was isolated from the bryozoanBugula dentata.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01975907
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  • 9
    Electronic Resource
    Electronic Resource
    Okinonellins A and B, two novel furanosesterterpenes, which inhibit cell division of fertilized starfish eggs, from the marine spongeSpongionella sp (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 1299-1300 
    Details
    ISSN: 1420-9071
    Keywords: Spongionella sp. ; porifera ; cell division inhibitor ; starfish embryos ; furanosesterterpene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two novel furanosesterterpenes, okinonellins A (1) and B (2), have been isolated from the spongeSpongionella sp. Both compounds inhibit cell division of starfish embryos.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946432
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  • 10
    Electronic Resource
    Electronic Resource
    A Comparison of the Plasma Fructose Concentrations in Dogs and Cats and Changes in the Fructose Concentrations in Dogs Following Intravenous Administration of Fructose (1999)
    Springer
    Veterinary research communications 23 (1999), S. 203-209 
    Details
    ISSN: 1573-7446
    Keywords: cat ; dog ; free fatty acids ; fructose ; glucose ; plasma ; triglycerides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The plasma concentrations of fructose, glucose, free fatty acids (FFA) and triglycerides (TG) were measured in dogs and cats. Changes in these concentrations were investigated in dogs by an intravenous fructose tolerance test (IVFTT) at a dose of 0.1 g/kg body weight. Fructose concentrations in the plasma of dogs were significantly higher than those of cats. There was no significant difference in plasma glucose concentrations between dogs and cats. Plasma FFA concentrations decreased and TG concentrations increased after feeding in both dogs and cats. During the IVFTT, the plasma fructose concentrations in the dogs increased rapidly to a peak by 2 min and then decreased to half of the peak by 5 min after the administration of fructose. Administration of fructose resulted in an increase in the plasma TG concentrations and reduced plasma FFA concentrations in the dogs. Only 4% of the administered fructose was detected in the urine of dogs following IVFTT. Plasma fructose was considered to be rapidly absorbed and metabolized in both dogs and cats. However, as with glucose metabolism, there appear to be some differences in fructose metabolism between dogs and cats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006203807735
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