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  • Articles: DFG German National Licenses  (6)
  • 1985-1989  (6)
  • 1987  (6)
  • 1
    Electronic Resource
    Electronic Resource
    Regional differences in local cerebral blood flow (LCBF) and glucose utilization (LCGU) in the basal ganglia after occlusion of the middle cerebral artery in rats (1987)
    Springer
    Journal of neural transmission 68 (1987), S. 271-287 
    Details
    ISSN: 1435-1463
    Keywords: Cerebral ischemia ; cerebral blood flow ; cerebral glucose utilization ; basal ganglia ; dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute effects of occlusion of the middle cerebral artery on local cerebral blood flow (LCBF) and local cerebral glucose utilization (LCGU) were investigated quantitatively in separate groups of rats using (14C) iodoantipyrine (14C-IAP) or (14C) 2-deoxyglucose (14C-DG) respectively. LCBF was significantly decreased in the ipsilateral cerebral cortices (to less than 45 ml/100 g/min or 30% of the control side) and the lateral part of the striatum (to 22 ml/100 g/min or 10% of the control side) which were supplied by the middle cerebral artery. No significant changes in LCBF were found in any other of the subcortical regions. In contrast to the unanimous decrease of LCBF in the ipsilateral cortices and the lateral striatum, complexed changes in LCGU were found in not only the cortex and striatum but also in many other subcortical regions which were closely related to the distribution of the mesencephalic dopamine neurons, such as globus pallidus, substantia nigra, subthalamic nucleus, nucleus accumbens, olfactory tubercle and lateral habenular nucleus. Relevance of this putative neurotransmitter and GABA on the glucose metabolism in ischemic brain is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02098503
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of the calcium antagonist nilvadipine on haemodynamics at rest and during cold stimulation in essential hypertension (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 215-219 
    Details
    ISSN: 1432-1041
    Keywords: nilvadipine ; calcium antagonist ; essential hypertension ; antihypertensive drug ; stress ; cold pressor test ; haemodynamics ; plasma renin ; plasma noradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The immediate haemodynamic effects of the calcium antagonist nilvadipine have been studied in ten patients with established mild essential hypertension. Nilvadipine 4 mg p.o. reduced both the systolic and diastolic blood pressures within 60 min, associated with a fall in total peripheral resistance and an increase in heart rate and cardiac index. The peak of blood pressure and total peripheral resistance reached during a cold pressor test were reduced by nilvadipine, but it did not affect the haemodynamic responsiveness to cold stimulation. Plasma renin activity was unaltered and the plasma noradrenaline concentration was increased only slightly. Thus, nilvadipine lowered blood pressure at rest and during cold stimulation as a result of arteriolar dilatation. The hypotensive effect at rest was associated with a reflex increase in heart rate and cardiac index.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637551
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of reduced frequency breathing on arterial hypoxemia during exercise (1987)
    Springer
    European journal of applied physiology 56 (1987), S. 522-527 
    Details
    ISSN: 1439-6327
    Keywords: Reduced frequency breathing ; Arterial hypoxemia ; Exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It is uncertain that exercise with reduced frequency breathing (RFB) results in arterial hypoxemia. This study was designed to investigate whether RFB during exercise creates a true hypoxic condition in arterial blood by examining arterial oxygen saturation (SaO2) directly. Six subjects performed ten 30 s periods of exercise on a Monark bicycle ergometer at a work rate of 210 W alternating with 30 s rest intervals. The breath was controlled to use 1 s each for inspiration and expiration, and two trials with different breathing patterns were used; a continuous breathing (CB) trial and an RFB trial consisting of four seconds of breath-holding at functional residual capacity (FRC). Alveolar oxygen pressure during exercise showed a slight but significant (p〈0.05) reduction with RFB as compared to CB. However, a marked increase in alveolar-arterial pressure difference for oxygen (A-aDO2) (p〈0.05) with RFB over CB resulted in a marked (p〈0.05) reduction in arterial oxygen pressure. Consequently, SaO2 fell as low as 88.8% on average. Additional examination of RFB with breath-holding at total lung capacity showed no increases in A-aDO2 in spite of the same amount of hypoventilation as compared with that at FRC. These results indicate that RFB during exercise can result in arterial hypoxemia if RFB is performed with breath-holding at FRC, this mechanism being closely related to the mechanical responses due to lung volume restriction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00635364
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Immunoactivity of polymer microspheres with their hydrophilic/hydrophobic heterogeneous surface sensitized with an antibody (1987)
    Springer
    Colloid & polymer science 265 (1987), S. 1061-1066 
    Details
    ISSN: 1435-1536
    Keywords: Polymer emulsion ; hydrophilicity ; heterogeneousstructure ; immunomicrosphere ; agglutinability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Styrene/2-hydroxyethyl methacrylate polymer microspheres consisting of various polymer compositions were produced by emulsifier-free seeded emulsion polymerization technique. Using these microspheres, which should have hydrophilic/hydrophobic heterogeneous surface, the effects of surface hydrophilicity on the main, fundamental requirements for an immunomicrosphere — high colloidal stability, sensitive immunologic agglutinability and insensitive non-specific agglutinability — were studied in detail. There was a region of the surface hydrophilicity that satisfied the three requirements simultaneously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01417463
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    On thumb-nail pattern of fatigue crack front observed in standard compact tension specimen (1987)
    Springer
    International journal of fracture 34 (1987), S. 149-157 
    Details
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Résumé On a procédé à l'observation de la forme en ongle que prend le front de la fissure de fatigue que l'on réalise au droit de l'entaille usinée des éprouvettes de traction compactes destinées aux essais de ténacité à la rupture. En supposant que la distribution du facteur d'intensité de contrainte K I le long du front de la fissure est égale à celle correspondant à un front de fissure originalement droit, on obtient un front de fissure légèrement incurvé grâce au recours à la loi de Paris sur la vitesse de croissance d'une fissure de fatigue. En comparant les résultats calculés et les observations expérimentales sur des éprouvettes 10 TCT, dont l'épaisseur atteint 247 mm, on trouver que l'effet de singularités des contraintes à l'intersection de la ligne de front de la fissure et des surfaces libres peut être négligé et que l'accord est extrêmement satisfaisant.
    Notes: Abstract The thumb-nail shape of a crack front has been observed in a compact tension (CT) specimen, when a fatigue crack is formed ahead of the machined notch in the course of preparation for the fracture toughness testing. Assuming that the distribution of the stress intensity factor K I along the crack front line is equal to that corresponding to the original straight crack front, a slightly curved crack front is obtained with the aid of Paris' law for the fatigue crack growth rate. Comparing the calculated results with the experimental observation in the 10 T CT specimens, whose thickness is 247 mm, it is found that the effect of the stress singularities at the intersection of the crack front line and the free surface can be disregarded and that they show extremely good agreement with each other.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00019769
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Breath-by-breath measurement of alveolar gas exchange with a slow-response gas analyser (1987)
    Springer
    Medical & biological engineering & computing 25 (1987), S. 141-146 
    Details
    ISSN: 1741-0444
    Keywords: Alveolar gas exchange ; Breath ; Gas analyser
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The O2-paramagnetic or polarographic and CO2-infra-red expired gas analyser have a response delay which results in an underestimation in breath-by-breath $$\dot vO_2 $$ and $$\dot vCO_2 $$ calculations. In this study, correction for this delay has been made. After measuring the step response of the O2-polarographic and CO2-infra-red analyser, the damping factor and the natural angular frequency were determined as well as the time constant, assuming the response was a first-order one. $$\dot vO_2 $$ and $$\dot vCO_2 $$ were calculated when the response of the analyser was corrected for the first- and second-order responses using the inverse Laplace transform. For the uncorrected $$\dot vO_2 $$ and $$\dot vCO_2 $$ , values from the breath-by-breath method were 27·5 and 18·1 per cent systematically underestimated (p〈0·001) compared with those of the Douglas bag method. When correction for the first-order response was made, values of the breath-by-breath method became equivalent to those of the Douglas bag method for $$\dot vCO_2 $$ whereas there was still a 17·5 per cent systematic underestimation (p〈0·001) for $$\dot vO_2 $$ . The correction for the second-order response gave equivalence and significant correlation (p〈0·001) between the values of both methods for $$\dot vO_2 $$ and $$\dot vCO_2 $$ . These results might indicate that breath-by-breath measurement of alveolar gas exchange with a slow-response gas analyser is valid when a second-order response delay correction is used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02442842
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    Paper (German National Licenses)
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