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  • Articles: DFG German National Licenses  (7)
  • 1990-1994  (7)
  • 1940-1944
  • 1935-1939
  • 1991  (7)
  • 1
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A group of 140 cases of various forms of lupus erythematosus (LE) were examined for 24 variables, inducting the 11 criteria of the American Rheumatism Association (ARA) for the classification of systemic lupus erythematosus (SLE), and 13 additional criteria suggested by the European Academy of Dermatology and Venerology (EADV) for studies of cutaneous LE with or without systemic involvement. The EADV study factors included skin histopathology and immunopathology, complement and IgG levels, and other laboratory tests, as well as selected clinical findings, most notably the papulosquamous and/or annular lesions that characterize sub acute cutaneous LE (SCLE). The patients examined included 50 SLE, 35 SCLE, 30 discoid LE (DLE), 25 disseminated DLE (DDLE), and 17 polymorphous light eruption (PMLE) cases. Preliminary analyses of the data reveal the following: (1) The SCLE cases differed significantly from SLE, DLE, and DDLE in 10 of 11 ARA criteria (all but photosensitivity). (2) The frequencies of positive findings in SCLE also differed significantly for 11 of 13 EADV study factors. (3) While no significant differences appeared in the frequency of photosensitivity between the five study groups, photo-testing revealed significant increases in the frequency of persistence of the photo reactions for 10 days and their Koebnerization in the SCLE cases. (4) The presence of SS-A (Ro)/SS-B (La) antibodies had some predictive value for the appearance of systemic involvement in SCLE, as seen by the increased frequencies of five or more ARA criteria, although highly significant differences from SLE occurred in the absence of renal involvement and lower frequency of ANA and LE band test. We conclude from these studies that the classification of the major forms of cutaneous LE, with and without systemic involvement, requires not only the ARA criteria, but also the examination of other factors such as those recommended by the EADV, and that the study groups should include SLE, SCLE, DLE, DDLE, and non-LE controls such as PMLE.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 30 (1991), S. 0 
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Machine vision and applications 4 (1991), S. 243-253 
    ISSN: 1432-1769
    Keywords: fluorescence imaging ; confocal ; median filtering ; biomedical microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract A different way of processing confocally scanned fluorescence images is presented. Linear median hybrid methods and linear filtering methods are compared numerically with a conventionally processed artificial data set and with real confocal data. The use of linear median hybrid techniques reduces the time required for recording three-dimensional data sets with a confocal fluorescence microscope as well as the photo-damage to the biological sample. The implementation of a linear median algorithm on the hardware level of a confocal microscope is discussed.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 18 (1991), S. 791-795 
    ISSN: 1619-7089
    Keywords: Human thyroid ; Iodine 125 autoradiography ; In vitro labelling of thyroid tissue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Samples of fresh thyroid tissue obtained from 15 patients undergoing thyroid surgery were incubated with iodine 125 in culture solution to which thyroid-stimulating hormone (TSH) had been added and then examined by autoradiography. The radioactivity registered actively during the 90-min incubation period was primarily found in the lumina of follicles. Even morphologically similar follicles showed very heterogeneous uptake of radioiodine; small follicles often contained the highest concentrations of activity. The method applied appears to be particularly useful for answering the question as to whether and to what extent individual papillary or follicular thyroid carcinomas are able to store radioiodine. This information obtained immediately after surgery may contribute towards establishing the patient's prognosis and help in deciding on postoperative therapy and follow-up. Because of the heterogeneity of radioiodine uptake, it is mandatory to examine a representative sample of carcinoma tissue in order to obtain well-established results.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Child & adolescent social work journal 8 (1991), S. 339-347 
    ISSN: 1573-2797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Sociology
    Notes: Abstract The justice system has witnessed the negative consequences of chemical abuse. Infants are especially vulnerable to harm as a result of maternal drug use. This article uses a legal perspective to examine the conflict between maternal and fetal rights and reviews selected decisions and laws designed to protect children from maternal drug use. It advocates a policy of state intervention in order to protect children from the damage which can accompany maternal chemical use.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Biologie in unserer Zeit 21 (1991), S. 19-25 
    ISSN: 0045-205X
    Keywords: Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Der Zellbiologe ist daran interessiert, spezifische Strukturen in Zellen sichtbar zu machen, urn mit dem Mikroskop die Morphologie zu untersuchen. Dabei macht er sich die Eigenschaften von Antikörpern zunutze, die bestimmte Moleküle innerhalb der Zelle erkennen und gezielt an ihnen binden. Um den Bindungsort der spezifischen Antikörper sichtbar zu machen, wird ein zweiter Antikörper zugefügt, der an die Oberfläche des ersten Antikörpers bindet. Dieser zweite Antikörper ist mit einem fluoreszierenden Molekül gekoppelt, das mit Licht einer kürzeren Wellenlänge angeregt wird und Licht einer längeren Wellenlänge wieder ausstrahlt (Abbildung 1). Mit Filtern lassen sich Anregung und Abstrahlung trennen, und die markierten Strukturen der Zelle leuchten in einem Fluoreszenzmikroskop hell auf. Die hier beschriebene Technik wird als indirekte Immunfluoreszenz bezeichnet, da erst der zweite Antikörper fluorochromiert ist.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal of Electron Microscopy Technique 18 (1991), S. 61-73 
    ISSN: 0741-0581
    Keywords: Fluorescence microscopy techniques ; Poleward chromosome movement ; Microtubule dynamics ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Natural Sciences in General
    Notes: Fluorescence microscopy techniques have become important tools in mitosis research. The well-known disadvantages of fluorescence microscopy, rapid bleaching, phototoxicity and out-of-focus contributions blurring the in-focus image are obstacles which still need to be overcome. Confocal fluorescence microscopy has the potential to improve our capabilities of analyzing cells, because of its excellent depth-discrimination and image processing power. We have been using a confocal fluorescence microscope for the study of the mechanism of poleward chromosome movement, and report here (1) a cell preparation technique, which allows labeling of fixation sensitive spindle antigens with acceptable microtubule preservation; (2) the use of image processing methods to represent the spatial distribution of various labeled elements in pseudocolour; (3) a novel immunoelectron microscopic labeling method for microtubules, which allows the visualization of their distribution in semithin sections at low magnification; and (4) a first attempt to study microtubule dynamics with a confocal fluorescence microscope in living cells, microinjected with rhodamine labeled tubulin.Our experience indicates that confocal fluorescence microscopy provides real advantages for the study of spatial colocalization of antigens in the mitotic spindle. It does not, however, overcome the basic limits of resolution of the light microscope. Therefore, it has been necessary to use an electron microscopic method. Our preliminary results with living cells show that it is possible to visualize the entire microtubule network in stereo, but that the sensitivity of the instrument is still too low to perform dynamic time studies. It will be worthwhile to further develop this new type of optical instrumentation and explore its usefulness on both fixed and living cells.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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