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  • 1
    Electronic Resource
    Electronic Resource
    High transition temperature superconductor LaBa2Cu3O7−y with zero resistance at 92 K (1988)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 52 (1988), S. 1989-1991 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Samples of LaBa2 Cu3 O7−y have been synthesized, which show a superconducting transition above 90 K. One of the samples shows a superconducting transition with an onset at 93 K and a zero resistivity at 92 K. These temperatures are the highest among those reported so far on this system and even higher than those in YBa2 Cu3 O7−y. The magnetic susceptibility measurement also shows that it has a superconducting transition with onset at around 93 K. To synthesize such good LaBa2 Cu3 O7−y requires two important procedures. First is sintering above 950 °C in N2 gas atmosphere and the second is annealing at 300 °C in dried O2 gas atmosphere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.99744
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  • 2
    Electronic Resource
    Electronic Resource
    Study on the preparation of 90-K superconductor LaBa2Cu3Oy (1988)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 64 (1988), S. 4095-4102 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The high-Tc superconductor LaBa2Cu3Oy has been prepared under various conditions, and characterized by x-ray and neutron powder diffraction techniques, dc and ac magnetic susceptibility measurements, and dc resistivity measurement. It has been found that samples with excellent superconducting characteristics and also with good structural properties are obtained in a reproducible way if the following three procedures are performed: preheat treatment of La2O3 powders, sintering in N2, and low-temperature annealing in dried O2. Long-time annealing in undried O2 was sometimes found to degrade the grain boundaries and to lead to a lower zero-resistance temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.341318
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  • 3
    Electronic Resource
    Electronic Resource
    6-GeV synchrotron radiation project : International conference on synchrotron radiation instrumentation (1989)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 60 (1989), S. 1719-1721 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: This paper outlines the status of a 6-GeV synchrotron radiation designed at RIKEN. This facility consists of a main storage ring, a booster synchrotron, a 1.5-GeV preinjector linac, positron injection linacs, and others. The electronan GeV. The storage ring has a circumference of 1069.2 m and 7-m-long straight sections for insertion devices. The lattice of the main ring is a Chasman–Green-type one and has 36 periodicity. The low emittance (εx=8.2 nm rad) and large dynamic aperture are expected even with field errors and misalignments of magnetic elements. Three years of a preconstruction research and development period and 5 years of construction period are scheduled.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1140937
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  • 4
    Electronic Resource
    Electronic Resource
    Expression of midkine and receptor-like protein tyrosine phosphatase (RPTP)-β genes in the rat stomach and the influence of rebamipide (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 18 (2003), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Midkine has been reported to bind to receptor-like protein tyrosine phosphatase (RPTP)-β and to play important roles in growth and differentiation of various cells. Midkine is expressed in rat stomach during experimental ulcer healing, suggesting that the midkine-RPTP-β system has some physiological functions in the stomach. Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers. We have tested the hypothesis that the ulcer healing mechanism stimulated by rebamipide is linked physiologically to the gastric midkine-RPTP-β system.Materials and methods : Seven-week-old-male Wistar rats were used. Midkine and RPTP-β gene expression in rat stomach was investigated by laser capture microdissection coupled with the reverse transcription-polymerase chain reaction (RT-PCR). The effects of rebamipide on midkine and RPTP-β expression in rat stomach and the gastric epithelial cell line RGM1 were evaluated by RT-PCR and Northern blot analyses.Results : Midkine and RPTP-β expression was detected in the gastric mucosal, submucosal and muscle layers. Rebamipide stimulated both midkine and RPTP-β expression in rat stomach and RGM1 cells.Conclusion : Rebamipide may protect the gastric mucosa by regulating midkine and RPTP-β expression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.18.s1.12.x
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  • 5
    Electronic Resource
    Electronic Resource
    A Japanese case of segmental Darier's disease caused by mosaicism for the ATP2A2 mutation (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Darier's disease is an autosomal dominant skin disorder that is characterized by multiple keratotic papules, focal loss of adhesion and abnormal keratinization. Mutations in the ATP2A2 gene encoding sarco/endoplasmic reticulum calcium pumping ATPase type 2 have been identified as the molecular basis of Darier's disease. Segmental Darier's disease is a rare type of Darier's disease in which there is characteristic localization of the keratotic papules in a linear pattern following Blaschko's lines. In this study we examined ATP2A2 mutations in a Japanese patient with segmental Darier's disease. The samples from affected skin, unaffected skin and peripheral leucocytes were subjected to polymerase chain reaction (PCR). Direct sequencing of the PCR products was performed. Sequence analysis revealed that the patient had 160A→G substitution mutation which predicts I54V. This novel mutation was present in the affected skin, but not in the unaffected skin or peripheral leucocytes. This is the first report of segmental Darier's disease caused by mosaicism for an ATP2A2 mutation in Japan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05412.x
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  • 6
    Electronic Resource
    Electronic Resource
    Geographical difference in mated status and autumn migration in the rice leaf roller moth, Cnaphalocrocis medinalis (1988)
    Springer
    Entomologia experimentalis et applicata 46 (1988), S. 141-148 
    Details
    ISSN: 1570-7458
    Keywords: rice leaf roller ; Cnaphalocrocis medinalis ; insect migration ; mating ; ovarian development ; light trap
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Résumé Une différence géographique dans l'activité reproductrice des papillons de la population de C. medinalis a été observée dans les champs de paddy d'automne du Kyushu septentrional au Japon. Cette différence géographique dans la fréquence des accouplements de la population ressemble à celle de l'importance de la densité d'immigration au début de l'été: la proportion de femelles inséminées est élevée dans les populations de la côte occidentale de Kyushu et basse dans la région intérieure. Les captures de papillons aux pièges lumineux, en 1985, suggèrent l'existence au Kyushu septentrional d'invasions d'outre-mer venant de Chine. Ces immigrations potentielles automnales de papillons dans les champs de paddy à maturité expliqueraient correctement les variations au cours de la même saison de l'activité reproductrice des papillons suivant les localités. Ces migrations ne sont apparemment pas adaptatives puisque les immigrants ou leur progéniture seront immédiatement tués à la récolte ou par le froid hivernal.
    Notes: Abstract A geographical difference in reproductive status of moths in populations of C. medinalis Guénée was recognized in autumn paddy fields of north Kyushu, south-west Japan. This geographical variation in mating frequency of the population resembled the intensity of immigrant density in early summer: the proportion of mated females in the population was high in the west coast regions of Kyushu and low in inland areas. Light trap catches of moths in 1985 suggested overseas invasions from China in the autumn to westerly regions of north Kyushu. The potential autumn immigrations of moths in ripening paddy fields would satisfactorily explain the variations in reproductive status of moths with locality in the same season. These migrations are apparently non-adaptive because immigrants or their progeny would soon be killed at harvest or from cold weather.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190844
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  • 7
    Electronic Resource
    Electronic Resource
    Chemokines: new target molecules in renal diseases (2000)
    Springer
    Clinical and experimental nephrology 4 (2000), S. 273-280 
    Details
    ISSN: 1437-7799
    Keywords: Key words Chemokine ; Chemokine receptor ; Kidney ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The presence of leukocytes in the diseased kidneys is a hallmark of almost any kind of renal disease. Activated leukocytes are implicated in playing a crucial role in the pathogenesis of renal diseases. Recent investigations of the pathophysiological roles of chemokines and their cognate receptors have shed light on the detailed molecular mechanisms of leukocyte trafficking and activation in the diseased kidneys. This study summarizes findings that: (1) chemokine/chemokine receptor systems may be essentially involved in the pathogenesis of phase-specific renal disorders, (2) the measurement of urinary levels of chemokines may be clinically useful for monitoring different disease phases and activities in human renal diseases, and (3) interventions in chemokine/chemokine receptor systems may have potential as particular immunotherapeutic strategies to combat specific phases of renal diseases. Further investigations of anti-chemokine therapies for renal diseases will be required before clinical application is feasible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570070001
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  • 8
    Electronic Resource
    Electronic Resource
    Clinicopathological features of antineutrophil cytoplasmic antibodies-associated vasculitis in Japanese patients with IgA nephropathy (2000)
    Springer
    Clinical and experimental nephrology 4 (2000), S. 251-256 
    Details
    ISSN: 1437-7799
    Keywords: Key words Antineutrophil cytoplasmic antibodies ; Crescentic glomerulonephritis ; Immunoglobulin A nephropathy ; Immunosuppressive therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Antineutrophil cytoplasmic antibodies (ANCA) have been reported to be associated with systemic vasculitis. However, the roles of ANCA subtypes in patients with IgA nephropathy remain to be fully investigated. We describe three Japanese patients with IgA nephropathy complicated by ANCA-associated vasculitis. Two patients with IgG class ANCA developed rapidly progressive renal failure and demonstrated mesangial proliferation with extensive extracapillary proliferation and segmental glomerular necrosis. One patient with IgM class ANCA showed severe extrarenal symptoms, such as lung fibrosis and neuritis, in addition to glomerular crescent formation. All three patients received immunosuppressive therapies, including corticosteroids and cyclophosphamide. The two patients who received these treatments early showed improvement in urinary protein excretion and renal function, in accordance with a decrease in the serum titer of ANCA. However, one patient in whom serum creatinine was already elevated showed a poor response to the treatment. These results suggest that ANCA subtypes may participate in the pathogenesis of crescent formation in patients with IgA nephropathy, and that early treatment with a combination of methylprednisolone pulse therapy, oral prednisolone, and cyclophosphamide pulse therapy may be beneficial in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570070030
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  • 9
    Electronic Resource
    Electronic Resource
    Prognostic value of P-glycoprotein expression in bone and soft-tissue sarcoma (2000)
    Springer
    International journal of clinical oncology 5 (2000), S. 164-170 
    Details
    ISSN: 1437-7772
    Keywords: Key words P-glycoprotein ; Osteosarcoma ; Soft-tissue sarcoma ; Prognosis ; Immunohistochemistry ; RT-PCR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. The purpose of this study was to investigate the correlation between P-glycoprotein status and outcome in adult patients with high-grade osteosarcomas and soft-tissue sarcomas. Methods. P-glycoprotein status was determined im-munohistochemically in specimens from 28 patients with osteosarcoma and 34 patients with soft-tissue sarcoma. The polyclonal antibody mdr(Ab-1) was used for either decalcified or undecalcified tissue samples which were formalin-fixed and paraffin-embedded. The expression of P-glycoprotein mRNA was also determined by the polymerase chain reaction in 23 fresh sarcoma specimens. P-glycoprotein status was analyzed in relation to the duration of event-free survival. Results. Positivity for P-glycoprotein was found in 29% of the osteosarcomas and 34% of the soft-tissue sarcomas. Consistent results were obtained at both the immunohistochemical and reverse transcriptase-polymerase chain reaction (RT-PCR) levels in 19 of 23 sarcomas (83%). In patients with osteosarcoma, the presence of increased levels of P-glycoprotein was significantly associated with a decreased probability of event-free survival after diagnosis (P = 0.022). In contrast, in patients with soft-tissue sarcoma there was no correlation between the level of P-glycoprotein and prognosis. Conclusions. In patients with high-grade osteosarcomas, the presence of increased levels of P-glycoprotein detected by polyclonal antibody mdr(Ab-1) was associated with a significantly increased risk of adverse events. This association was not found in patients with soft-tissue sarcomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012032
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  • 10
    Electronic Resource
    Electronic Resource
    Phase-dependent shift of free-running human circadian rhythms in response to a single bright pulse (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 1205-1207 
    Details
    ISSN: 1420-9071
    Keywords: Human circadian rhythm ; bright light pulse ; phase-shift ; temporal isolation ; phase response curve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Responsiveness of free-running human circadian rhythms to a single pulse of bright light was examined in a temporal isolation unit. Bright light (5000 lx) of either 3 or 6 h duration, applied during the early subjective day, produced phase-advance shifts in both the sleep-wake cycle and the rhythm of rectal temperature; the light pulse had essentially no effect on the phase of the circadian rhythms, when it was introduced during the late subjective day or the early subjective night. The results indicate that bright light can reset the human circadian pacemaker.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01945525
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