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  • Articles: DFG German National Licenses  (90)
  • 2000-2004  (71)
  • 1980-1984  (18)
  • 1830-1839  (1)
  • 11
    Electronic Resource
    Electronic Resource
    Synergistic Depletion of Astrocytic Glutathione by Glucose Deprivation and Peroxynitrite (2000)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 74 (2000), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Previously we reported that immunostimulated astrocytes were highly vulnerable to glucose deprivation. The augmented death was mimicked by the peroxynitrite (ONOO--producing reagent 3-morpholinosydnonimine (SIN-1). Here we show that glucose deprivation and ONOO- synergistically deplete intracellular reduced glutathione (GSH) and augment the death of astrocytes via formation of cyclosporin A-sensitive mitochondrial permeability transition (MPT) pore. Astrocytic GSH levels were only slightly decreased by glucose deprivation or SIN-1 (200 μM) alone. In contrast, a rapid and large depletion of GSH was observed in glucose-deprived/SIN-1-treated astrocytes. The depletion of GSH occurred before a significant release of lactate dehydrogenase (a marker of cell death). Superoxide dismutase and ONOO- scavengers completely blocked the augmented death, indicating that the reaction of nitric oxide with superoxide to form ONOO- was implicated. Furthermore, nitrotyrosine immunoreactivity (a marker of ONOO-) was markedly enhanced in glucose-deprived/SIN-1-treated astrocytes. Mitochondrial transmembrane potential (MTP) was synergistically decreased in glucose-deprived/SIN-1-treated astrocytes. The glutathione synthase inhibitor L-buthionine-(S,R)-sulfoximine markedly decreased the MTP and increased lactate dehydrogenase (LDH) releases in SIN-1-treated astrocytes. Cyclosporin A, an MPT pore blocker, completely prevented the MTP depolarization as well as the enhanced LDH releases in glucose-deprived/SIN-1-treated astrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2000.0741989.x
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  • 12
    Electronic Resource
    Electronic Resource
    Stoichiometry of the vinblastine-induced self-association of calf brain tubulin (1980)
    s.l. : American Chemical Society
    Biochemistry 19 (1980), S. 1347-1354 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00548a013
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  • 13
    Electronic Resource
    Electronic Resource
    Effects of heating rate and surface oxidation on magnetic induction of 3% Si–Fe strip (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 5236-5238 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effects of heating rate and surface oxidation on magnetic induction of thin-gauged 3% Si–Fe strips have been investigated. Magnetic induction increased with increasing final annealing temperature. Before and after 1150 °C, the planar orientation of grains shifted from (100)[011] to (110)[001], resulting in magnetic induction higher than 1.90 T. Magnetic induction after final annealing was higher in case of a faster heating rate. This is because enough time for growth of (110) grains is given in the case. Irrespective of transient annealing temperature, magnetic induction after final annealing was mostly higher than 1.90 T. A maximum, 1.97 T, was obtained at a transient annealing temperature of 800 °C. This is because iron oxide formed at 800 °C inhibited the surface-energy-induced selective growth of (100)[011] grains during heating up to 1200 °C. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.373306
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  • 14
    Electronic Resource
    Electronic Resource
    Angioma serpiginosum with retinal involvement in a male: a possible aetiological role of continuous cold exposure (2004)
    Oxford, UK : Blackwell Publishing Ltd.
    Journal of the European Academy of Dermatology and Venereology 18 (2004), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.2004.00899.x
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  • 15
    Electronic Resource
    Electronic Resource
    Above-room-temperature ferromagnetism in GaSb/Mn digital alloys (2002)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 81 (2002), S. 511-513 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Digital alloys of GaSb/Mn have been fabricated by molecular-beam epitaxy. Transmission electron micrographs showed good crystal quality with individual Mn-containing layers well resolved, no evidence of three-dimensional MnSb precipitates was seen in as-grown samples. All samples studied exhibited ferromagnetism with temperature-dependent hysteresis loops in the magnetization accompanied by metallic p-type conductivity with a strong anomalous Hall effect (AHE) up to 400 K (limited by the experimental setup). The anomalous Hall effect shows hysteresis loops at low temperatures and above room temperature very similar to those seen in the magnetization. The strong AHE with hysteresis indicates that the holes interact with the Mn spins above room temperature. All samples are metallic, which is important for spintronics applications. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1481184
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  • 16
    Electronic Resource
    Electronic Resource
    Thermodynamic linkage between tubulin self-association and the binding of vinblastine (1980)
    s.l. : American Chemical Society
    Biochemistry 19 (1980), S. 1355-1365 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00548a014
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  • 17
    Electronic Resource
    Electronic Resource
    Real-time extraction of plasma equilibrium parameters in KSTAR tokamak using statistical methods : Papers from the thirteenth topical conference on high temperature plasma diagnostics (2001)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 1400-1405 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: To improve inherent shortcomings of statistical methods and apply them to the extraction of plasma equilibrium parameters in a fast timescale for real-time plasma control, new concepts of statistical methods such as principal component analysis-based neural network (NN), functional parametrization (FP)-based NN and double network are introduced by modifying NN and FP. These new methods are benchmarked and compared with the conventional techniques of NN and FP in a simple single-filament system. As a result of their applications to identification of plasma equilibrium parameters in the Korea Superconducting Tokamak Advanced Research tokamak, particularly, the double network concept among them has successfully achieved the improvement of drawbacks in the conventional methods. It is shown that more reliable results from the double network method can be obtained by combining several different statistical treatments as a primary network. Even in the case of nonoptimized methods united as a primary network, quite acceptable results can be achieved in the double network method. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1315639
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  • 18
    Electronic Resource
    Electronic Resource
    IL-18 Production in Human Pulmonary and Pleural Tuberculosis (2002)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 56 (2002), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Interleukin-18 (IL-18) has multiple important pro-inflammatory effects, including the induction of interferon-γ (IFN-γ) in various diseases. In this study, we investigated the IL-18-producing activities in human pulmonary and pleural tuberculosis (TB) in response to purified protein derivative (PPD) antigen (Ag) from Mycobacterium tuberculosis. The most significant IL-18 production was found in chronic refractory TB (CRTB) patients. However, IFN-γ production in CRTB patients was significantly less than that in healthy tuberculin reactors or in patients with tuberculous pleurisy (TBP). Elevated levels of both IL-18 and IFN-γ were found in pleural fluids from TBP patients. In vitro production of IL-18 was dramatically decreased following an 18 h stimulation with PPD. However, IFN-γ was markedly increased in pleural mononuclear cells from TBP patients after in vitro stimulation with PPD. The mesothelial cell type was the main source of pro-IL-18 in pleural cells from TBP patients, suggesting an important role for these cells in TBP. Taken together, these data indicate that IL-18 is elevated in peripheral blood mononuclear cells from CRTB patients, as well as at the site of TBP, indicating a possible role for IL-18 in both protective immunity and pathologic responses in human TB.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2002.01143.x
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  • 19
    Electronic Resource
    Electronic Resource
    Colour degradation of acidified vegetable juice (2004)
    Oxford, UK : Blackwell Science Ltd
    International journal of food science & technology 39 (2004), S. 0 
    Details
    ISSN: 1365-2621
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Mixed vegetable juice was acidified to a pH below 4 and subjected to pasteurization regimes between 80 and 100 °C. Hunter colour scale values (L, a and b) of the pasteurized samples were analysed to determine the kinetics of green and total colour degradation. The ‘a’ value was chosen as the physical parameter for green colour while ‘Lab’ represented the total colour. A concept, based on fractional conversion, was used for the determination of kinetic parameters. The results revealed that degradation of green and total colour of the acidified vegetable juice followed first-order kinetics. Temperature dependency of the rate constants for both the green and the total colour could be described by the Arrhenius relationship. The activation energies of green and total colour degradation were 49.19 and 29.00 kJ mol−1, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.2004.00802.x
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  • 20
    Electronic Resource
    Electronic Resource
    Isozyme variation among four species of the catfish genus Clarias (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 60 (2002), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Native Thai species of Clarias catfishes and one species introduced from Africa can be easily distinguished by horizontal starch gel electrophoresis of allozymes. An undescribed species of Clarias was collected from Thailand and found to possess several fixed allelic differences from the Clarias previously studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.2002.tb02428.x
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