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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Anthropology 13 (1984), S. 143-155 
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Some classes of stars, including novae and supernovae, undergo explosive outbursts that eject stellar material into space. In 2002, the previously unknown variable star V838 Monocerotis brightened suddenly by a factor of ∼104. Unlike a supernova or nova, it did not ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Applied microbiology and biotechnology 15 (1982), S. 25-32 
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract By preselection of microorganisms which preferentially attack the side chain of cholesterol we have been able to isolate a mutant of Corynebacterium spec. Chol 73 which forms 20-carboxy-pregna-1,4-dien-3-one (BNC) from cholesterol in nearly quantitative yields. The structure of this compound has been established by means of13C NMR-,1H NMR and CD spectroscopy.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1436-6304
    Keywords: Schlüsselwörter: Wettbewerbsreaktion – Wettbewerbsstrategie – Marketing-Mix – Stochastisches Modell ; Key words: Competitive reaction – Competitive strategy – Marketing mix – Stochastic model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Description / Table of Contents: Abstract. One particularly predominant current challenge to quantitative management science is the modeling and analysis of competitive actions and reactions. Approaches following the stimulus response paradigm are able to take into account the limited access to a company's internal decision making processes. In the present paper the most significant characteristics of a behavioristic analysis of competitive reactions are described. Furthermore, a stochastic model of competitive reactions by the simultaneous use of several marketing instruments is proposed. The empirical evidence of the model will be demonstrated with POS scanner data on frequently purchased consumer goods.
    Notes: Zusammenfassung. Eine der vordringlichsten gegenwärtigen Herausforderungen an die quantitative Management-Wissenschaft ist die Modellierung und Analyse von Wettbewerbsaktionen und -reaktionen. Dem begrenzten Zugang zu unternehmensinternen Entscheidungsprozessen kann durch die behavioristische Modellierung des Wettbewerbsverhaltens entsprechend dem Stimulus-Response-Paradigma Rechnung getragen werden. Im vorliegenden Beitrag werden wesentliche Charakteristika der behavioristischen Analyse von Wettbewerbsreaktionen dargestellt. Darüber hinaus wird ein stochastisches Modell der Wettbewerbsreaktion durch den simultanen Einsatz verschiedener Marketinginstrumente vorgestellt. Die empirische Überprüfung des Modells erfolgt anhand eines POS-Scannerdatensatzes für ein Konsumgut des täglichen Bedarfs.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Czechoslovak journal of physics 31 (1981), S. 198-208 
    ISSN: 1572-9486
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 7
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    Dordrecht : Periodicals Archive Online (PAO)
    Theory and Decision. 12:1 (1980:Mar.) 61 
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 189 (1980), S. 171-180 
    ISSN: 1432-041X
    Keywords: Amino acyl-tRNA synthetases ; Development ; Nuclear-mitochondrial interactions ; Neurospora
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The specific activities of the branched chain amino acyl-tRNA synthetases from the cytosolic and mitochondrial fractions ofN. crassa were low in dormant conidia and increased during germination, reaching a maximum 8 h after inoculation. This stage of development is characterised by high rates of many other cellular activities. The increases in activity of synthetases of both cytosol and mitochondria are inhibited by cycloheximide indicating that they are synthesized on cytoplasmic ribosomes. The mitochondrial synthetases show a stimulation of their specific activity when mitochondrial RNA and protein synthesis are inhibited by either ethidium bromide or chloramphenicol suggesting that a mitochondrial translation product regulates the synthesis of the mitochondrial synthetases. The activities of amino acyl-tRNA synthetases are dependent on energy production. When respiration is uncoupled from oxidative phosphorylation, synthetase specific activities decrease although the activities of other mitochondrial enzymes like NADH-dehydrogenase increase. This phenomenon suggests that more than one mechanism regulates the synthesis of mitochondrial proteins which are formed on cytoplasmic ribosomes. The synthesis of branched chain amino acyl-tRNA synthetases ofNeurospora is neither repressed by their cognate amino acids, nor is there inhibition by the precursors of these amino acids, as has been observed in other amino acyl-tRNA synthetases of various organism includingNeurospora.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0942-0940
    Keywords: Keywords: Brain neoplasms; magnetic resonance imaging; tomography, X-ray computed; ultrasonics.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ Purpose. In this prospective study the results of multimodal postoperative neuro-imaging were related to the survival of patients with high grade gliomas.  Methods. All 73 patients included underwent microsurgical tumour resection and had postoperative CT and transcranial sonography (TCS) examinations. In addition, 35 of the 73 patients received an early postoperative MRI. Patients were followed up for at least one year.  Findings. At the end of the 7 year study period 56 patients had died. The median survival time was 371 days. Survival rate was significantly higher in patients with anaplastic astrocytomas and inpatients displaying complete tumour resection on MRI (log-rank-test, p〈0.05) or a small postoperative residual tumour bulk on TCS (log-rank-test, p〈0.05). Cox proportional hazards model identified histological tumour grade, postoperative Karnofsky index, complete resection based on MRI and small postoperative residual tumour mass on TCS as independent predictors of survival.  Interpretation. This study demonstrates that early postoperative neuro-imaging has prognostic implications for the survival of patients with high grade gliomas. According to our results postoperative imaging with MRI and TCS is a valuable prognostic with regard to patient survival and should therefore be implemented in postoperative follow-up. It also helps to evaluate the efficacy of adjuvant therapy.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 26 (2000), S. S165 
    ISSN: 1432-1238
    Keywords: Key words Peritonitis ; Sepsis ; Septic courses ; Diagnosis ; Cytokines ; Procalcitonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: To assess the accuracy of procalcitonin as a measure of severity in patients with septic abdominal illnesses and the sepsis syndrome, to compare measurements with those of other inflammatory mediators, and to predict outcome.¶Methods: We carried out a prospective clinical study from 246 patients with infective or septic episodes confirmed at laparotomy and 66 patients undergoing elective operations who acted as controls. Specimens of blood for measurement of cytokine concentrations determination were obtained daily from septic patients. In the control group specimens were obtained before operation, at the end of operation, and on each of the following days until normal recovery (day 10). Every two weeks up to 3 months for patients with metastases, who were being followed up.¶Results: Compared with other cytokines such as tumor necrosis factor αa and interleukin 6 procalcitonin was closely related to the development of infective and septic complications. 59 of 246 patients (24 %) with sepsis died. Procalcitonin concentrations preoperatively [median 2.05 compared with 4.2 ng/ml (p = 0.08)] (Mann-Whitney U-test) did not differ, but those on the days 1, 4 and at the end differed significantly [day 1: 4.9 compared with 13.8 ng/ml (p 〈 0.01); day 4: 4.8 compared with 13.0 ng/ml (p 〈 0.01) and 0.4 compared with 13.25 ng/ml (p 〈 0.01) at the end of the study]. In the control group only 7 (1.6 %) of all blood samples, were detected outside the normal range (up to 0.8 ng/ml).¶Conclusions: Procalcitonin is a new indicator of infection and sepsis. TNF and IL-6 concentrations always rise after major operations and fall in the absence of infection, indicating operative trauma. Procalcitonin is sensitive in detecting infective complications. Under routine conditions the procalcitonin concentrations seems to be valid, reproducible and detectable.
    Type of Medium: Electronic Resource
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