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  • Articles: DFG German National Licenses  (20)
  • 1995-1999  (15)
  • 1985-1989  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Expression of mRNA for androgen receptor, 5α-reductase and 17β-hydroxysteroid dehydrogenase in human dermal papilla cells (1999)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 141 (1999), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to determine whether adrenal and gonadal weak androgens are utilized to form active androgens in human hair, we studied the expression of mRNA for androgen receptor (AR), 5α-reductase and 17β-hydroxysteroid dehydrogenase (17β-HSD) in cultured dermal papilla cells (DPCs) from various body sites. AR mRNA was expressed in beard (Be) and axillary hair (Ax) DPCs from both sexes, but only at a low level in DPCs from occipital scalp hair (OS). Type I 5α-reductase mRNA was expressed by all DPCs. Type II 5α-reductase mRNA was identified in beard DPCs, but was absent from OS and Ax DPCs. Type II 17β-HSD mRNA was strongly expressed in outer root sheath cells (ORSCs), while DPCs except for male Ax expressed no type II 17β-HSD mRNA. In contrast, type III 17β-HSD mRNA was strongly expressed in Be DPCs and Ax DPCs from both sexes; ORSCs showed a low level of expression. Expression of type III 17β-HSD mRNA was not regulated by androgen in DPCs. These results suggest that the sensitivity of hairs to androgen is partially controlled by the site-specific expression of AR, 5α-reductase and 17β-HSD in DPCs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1999.03156.x
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  • 2
    Electronic Resource
    Electronic Resource
    Electrical properties of InAlAs/InGaAs modulation doped structure after SiN passivated annealing (1997)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 81 (1997), S. 1311-1314 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effect of thermal annealing on the InAlAs/InGaAs modulation-doped structure, passivated with a SiN film, was investigated. In contrast to the capless sample, the passivated modulation-doped sample exhibited negligible degradation in the two-dimensional electron gas concentration (NS) after annealing at 280 °C, indicating that SiN is an efficient passivation material to ensure good thermal stability for the InAlAs/InGaAs modulation-doped structure. In addition, partial recovery in NS was found by annealing the SiN-passivated sample that had experienced serious NS degradation. A series of secondary ion mass spectroscopy (SIMS) measurements and Hall effect measurements revealed that the recovery of NS is associated with the discharge of fluorine atoms from the Si-doped n-type InAlAs layer. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.363911
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  • 3
    Electronic Resource
    Electronic Resource
    Reduction of internal stress in sputter-deposited films by energetic ion bombardment (1996)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 68 (1996), S. 3743-3745 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Considerable relaxation of the high internal stresses which arise in HfN thin films during their deposition by a sputtering method has been accomplished through bombarding the films with energetic silicon ions. The internal stresses have been estimated from the measurements of the surface curvature. Our results indicate a relaxation of the internal compressive stresses in the films, which occurs via a transport of the interstitial defects within the thermal spikes created by a post-deposition energetic ion bombardment. The mechanical properties of HfN films before and after the treatment have been studied by depth-sensing indentation technique while the structural analysis has been made using x-ray diffraction, Rutherford backscattering, and Auger electron spectroscopy. Ion bombardment did not affect resistivity of the thin films while improving their plastic properties. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.115992
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  • 4
    Electronic Resource
    Electronic Resource
    Spin glass in Fe-Ni Invar alloys (1985)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 57 (1985), S. 3456-3458 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Initial ac susceptibility χ was examined in the temperature range from 4.2 K to Curie temperatures for polycrystalline Fe100−xNix (20≤x≤50) alloys. The reentrant spin glass is found in x=30–45 alloys. The dependence of the freezing temperature Tg on the intensity of driving magnetic field (ac: 0–0.26 Oe; dc: 0–10 Oe) and on the frequency (140–9200 Hz) was studied for the Fe65Ni35 alloy. A strong magnetic relaxation is observed below Tg. These results are discussed based on the cluster model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.335075
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  • 5
    Electronic Resource
    Electronic Resource
    Enhanced interstitial expression of caldesmon and its suppression by glucocorticoid and heparin therapy in IgA nephropathy patients (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 4 (1998), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1797.1998.tb00443.x
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  • 6
    Electronic Resource
    Electronic Resource
    Interaction of 5-fluorouracil with sodium poly-α,L-glutamate (1985)
    Springer
    Colloid & polymer science 263 (1985), S. 682-685 
    Details
    ISSN: 1435-1536
    Keywords: 5-trifluorouracial ; sodium poly-α ; L-glutamate ; interaction ; viscosity ; 5-trifluoromethyluracil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The purpose of our research is to obtain an understanding of the binding mechanism and its correlations in terms of chemical structure and the potentiactive drug activity. The interaction of 5-fluorouracil (5-fluorouracil is used as an anticancer drug) with sodium poly-α,L-glutamate in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the molar change in enthalpy, entropy and the number of binding sites on the polymer were calculated. It is very interesting that the value ofΔH0 of the binding of 5-fluorouracil with sodium poly-α,L-glutamate is smaller than that of 5-trifluoromethyluracil (although 5-trifluoromethyluracil is not used as an anticancer drug, the compound has a similar structure to 5-fluorouracil).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419893
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  • 7
    Electronic Resource
    Electronic Resource
    UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan (1998)
    Springer
    Annals of oncology 9 (1998), S. 845-847 
    Details
    ISSN: 1569-8041
    Keywords: genetic polymorphism ; glucuronidation ; irinotecan ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Irinotecan (CPT-11) is metabolized by esterase to form a SN-38, which is further conjugated by UGT1A1. Genetic polymorphism has been shown in a promoter region of UGT1A1 and is related to its activity. We investigated whether there might be an inter-individual difference in pharmacokinetics of SN-38 and its glucuronide, depending on the genotypes of UGT1A1. Patients and methods: Nine male patients with lung cancer were treated with irinotecan (50 mg/m2) and carboplatin. Pharmacokinetic parameters were calculated with full sampling plasma data. Genotypes were determined by analyzing the sequence of TATA box of UGT1A1 of genomic DNA from the patients. Results: The genotyping analysis revealed one heterozygote (6/7) and one homozygote (7/7) for (TA)7TAA allele (UGT1A1*28). The remaining seven patients were homozygote for (TA)6TAA allele (6/6, wild type). The metabolic ratios (SN-38/SN-38 glucuronide) in the patient with 7/7 genotype were uncharacteristically higher than those in the patients with other genotypes (6/6 and 6/7). Biliary index was 6980 versus 2180 ± 1110 (range 840–3730) in patients with 7/7 versus 6/6 genotypes, respectively. Conclusion: These results support the idea that the patient with 7/7 genotype has an impaired capacity for glucuronidation of SN-38.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008438109725
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  • 8
    Electronic Resource
    Electronic Resource
    Further measurement of the 7Be(p,γ)8B cross section at low energies with the coulomb dissociation of 8B (1998)
    Springer
    The European physical journal 3 (1998), S. 213-215 
    Details
    ISSN: 1434-601X
    Keywords: PACS: 25.40.Lw Radiative capture – 35.60.-t Reactions induced by unstable nuclei – 25.70.De Coulomb excitation – 25.70.Mn Projectile and target fragmentation – 26.65.+t Solar neutrinos
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: We have measured the dissociation of 8B in the Coulomb field of 208Pb at Ein=51.9 MeV/nucleon and extracted the cross section of the 7Be(p,γ)8B reaction at 0.4 ≤ Erel≤ 3 MeV, which is of importance for the 8B solar-neutrino production rate. The extracted astrophysical S17 factors are consistent with our earlier Coulomb dissociation measurement, and agree with the values deduced from the direct capture measurements by Filippone et al., Vaughn et al. and Hammache et al. The S factor at zero energy was extracted to be 18.9±1.8 eV-b with the help of theoretical energy-dependence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100500050170
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  • 9
    Electronic Resource
    Electronic Resource
    Calpain activates two transglutaminases from porcine skin (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 380-384 
    Details
    ISSN: 1432-069X
    Keywords: Calpain ; Transglutaminase ; Thrombin ; Dimethyl sulfoxide ; Heating
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two transglutaminases (TGase) with estimated molecular weight of 55,000 (55-K TGase) and 120,000 (120-K TGase) were partially purified from the cytosolic fraction of porcine skin (epidermis-rich preparation) using DEAE-cellulose and gel-filtration chromatographies. The enzyme activities of both trans-glutaminases were enhanced more than 20-fold by treatment with calpain (Ca2+-dependent cysteine proteinase) in the presence of Ca2+, and this enhancement was inhibited by adding EDTA, leupeptin, or an endogenous calpain-specific inhibitor protein (calpastatin). 55-K TGase was effectively activated by a smaller amount of calpain than was 120-K TGase, while known activating reagents such as thrombin and dimethyl sulfoxide or heat treatment preferentially activated 120-K TGase. One of the physiological functions of calpain in the epidermis may be the activation of epidermal transglutaminases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426618
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  • 10
    Electronic Resource
    Electronic Resource
    Purification and magnetic properties of carbon nanotubes (1998)
    Springer
    Applied physics 67 (1998), S. 23-27 
    Details
    ISSN: 1432-0630
    Keywords: PACS: 81.40.-z; 81.40.Rs; 76.30.-v
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003390050733
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