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ERYTHROCYTE 2,3-DIPHOSPHOGLYCERATE AND ASSOCIATED HAEMATOLOGICAL PARAMETERS DURING THE MENSTRUAL CYCLE AND PREGNANCY (1977)

Macdonald, R. G. ; Macdonald, H. N.

Oxford, UK : Blackwell Publishing Ltd

BJOG 84 (1977), S. 0

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ISSN: 1471-0528

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and associated haematological parameters were measured throughout the normal menstrual cycle, in each trimester of pregnancy and on the third day post partum. There was no significant change during the menstrual cycle but the 2,3-DPG concentration was increased early in pregnancy, and thereafter gradually decreased. Although other metabolic changes are likely to contribute to the increase in 2,3-DPG concentration, it is concluded that ‘functional anaemia’, secondary to increased oxygen demand, is a more important stimulus than the decrease in haemoglobin concentration. The implications of a decreased oxygen affinity of haemoglobin, secondary to the rise in 2,3-DPG concentration, are discussed in relation to anaemia and blood transfusion in pregnancy.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1471-0528.1977.tb12617.x

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Production of insulin-like growth factor I (IGF-I) and IGF-binding proteins by rat intestinal stromal cells in vitro (1998)

MacDonald, R. G. ; McCusker, R. H. ; Blackwood, D. J. ; [et al.]

Springer

Cellular and molecular life sciences 54 (1998), S. 158-166

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ISSN: 1420-9071

Keywords: Key words. Insulin-like growth factors; IGFs; IGFBP; stroma; epithelium; stromal-epithelial interactions.

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract. To determine if intestinal stromal cells secrete diffusible factors such as insulin-like growth factors (IGFs) capable of regulating epithelial cell growth in vitro, stromal cells were isolated by enzymatic digestion of rat intestine. Incorporation of [3H]thymidine into DNA and [14C]leucine into protein of IEC-6 cells, a model intestinal epithelial cell line, was significantly increased (two- to threefold) when the IEC-6 cells were co-cultured with stromal cells, relative to IEC-6 cells grown alone. Medium conditioned by stromal cells stimulated DNA synthesis of IEC-6 cells in a dose-dependent manner. Analysis of the conditioned medium revealed that intestinal stromal cells secreted IGF-I, but little IGF-II, in addition to an M r 32,000 IGF-binding protein (IGFBP-2) and an IGFBP having M r∼ 24,000. We conclude that rat intestinal stromal cells secrete one or more diffusible factors, which may include IGF-I and IGFBPs, capable of stimulating proliferation of IEC-6 cells in vitro.