Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The pathogeneses of allergic rhinitis and bronchial asthma are believed to be closely mutually related because of the similar dynamics of allergy-inducing cells and molecules and clinical overlap. In this study, we compared these diseases in the dynamics of cell apoptosis-regulating molecules. Methods: Allergic rhinitis patients (n=36), bronchial asthma patients (n=22), and healthy subjects (n=32) were subjected to measurement of serum (soluble Fas) (sFas) levels during the stable and attack disease phases by a sandwich enzyme-linked immunosorbent assay. Results: Serum sFas levels in patients with allergic rhinitis during the attack phase were significantly lower (P〈0.0001) than those in healthy individuals. There were no differences between them during the attack and stable disease phases. In contrast, serum sFas levels in patients with bronchial asthma during the attack phase were higher (P〈0.0005) than those in healthy individuals. Interestingly, the levels during the attack phase were lower (P〈0.002) than those during the stable phase. Conclusions: Our results suggest a different pathogenesis for allergic rhinitis and bronchial asthma at the cell apoptosis-linked step.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 215-217 
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Crystals of 7α-hydroxysteroid dehydrogenase from E. coli, which is a tetramer in its active form, have been obtained by a hanging-drop vapor-diffusion method in the presence of the coenzyme NAD+. Crystals as large as 0.25 × 0.25 × 0.75 mm could be grown within a month at pH 8.5 with polyethylene glycol as precipitating agent. Preliminary X-ray crystallographic analysis revealed that they belong to one of the enantiomorphic space groups P41212 or P43212 with dimensions a = b = 81.66 and c = 214.6 Å, having two subunits in an asymmetric unit. The crystals diffract to at least 2.3 Å resolution.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1437-2320
    Keywords: Mannitol ; Prolongation of the tolerance in artery occlusion ; Artery occlusion ; Cerebral aneurysm ; Sequelae of aneurysm surgery ; Mannitol ; Prolongation der Toleranzzeit für Hirnarterienverschluß ; Arterienverschluß ; chirurgische Operation von Aneurysmen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Aufgrund der Ergebnisse bei 384 Patienten mit Hirnaneurysmen wird die Wirkung von Mannitol für die Prolongation der Toleranzzeit des Verschlusses einer Hirnarterie diskutiert. Der chirurgische Eingriff an den Arterien wurde ausgeführt mit einem zeitweiligen Verschluß der afferenten Arterie und einer praeoperativen Gabe von Mannitol unter Normothermie und Normotension. 1. Bei den Patienten, bei denen es zu Symptomen kam oder die starben, wurden die Ursachen für die Verschlechterung untersucht. Meistens war es Vasospasmus, eine chirurgische Komplikation oder eine Infektion. Bei 4 Patienten allerdings konnte der Grund für die Verschlechterung nicht gefunden werden. Die Möglichkeit, daß diese Patienten einen Schaden durch den zeitweiligen Verschluß von Hirnarterien erlitten, konnte nicht ausgeschlossen werden. 2. Die längste Verschlußzeit bei Patienten ohne Folgen war für jede Hauptarterie 80 Minuten bei unilateralem Verschluß des A1-Abschnittes der A.cerebri anterior und 65 Minuten bei einem bilateralen Verschluß des A1-Abschnittes, 57 Minuten für den intrakranialen Verschluß der A.carotis interna, 65 Minuten bei der A.cerebri media. 3. Die chirurgischen Ergebnisse von 384 Patienten endeten mit 13 Todesfällen und einer Mortalitätsrate von 3%. Eine katamnestische Studie von 371 überlebenden Patienten nach mindestens 6 Monaten vom Tag des chirurgischen Eingriffes brachte das Ergebnis, daß 82% aller Patienten ein normales soziales Leben führen konnten.
    Notes: Summary The effect of mannitol for prolongation of the tolerance time for cerebral artery occlusion is discussed based on data in 384 patients with cerebral aneurysm. Intracranial direct surgery was performed by employing temporary occlusion of the afferent artery and preoperative administration of mannitol under normothermia and normotension. (1) In the patients who experienced sequelae or died, the causes of deterioration were studied. Most of them were due to vasospasm, surgical complication, or infection. In 4 patients, the cause of deterioration was obscure. The possibility that these patients were affected by temporary occlusion of cerebral arteries could not be ruled out. (2) The longest occlusion time in the patients without sequelae for each main artery was 80 minutes at the unilateral A1 of the anterior cerebral artery, 65 minutes at the bilateral A1, 57 minutes at the intracranial internal carotid artery and 65 minutes at the middle cerebral artery. (3) The surgical result of the 384 patients at discharge included 13 deaths, a mortality rate of 3%. Follow-up study of 371 surviving patients after at least 6 months from surgery revealed that 82% of all patients were living normal social lives.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 50 (1979), S. 259-264 
    ISSN: 0942-0940
    Keywords: Intracranial saccular aneurysm ; conservative treatment ; follow-up study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Despite our basic policy of performing intracranial definitive surgery whenever possible in cases of intracranial saccular aneurysms, we have had 80 patients with non-radically treated aneurysms. This investigation is based on an analysis of the prognosis in 54 cases where we refused definitive surgery; it provides insight into the factors and circumstances leading to the use of treatment of secondary choice, conservative rather than definitive treatment.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1432-0533
    Keywords: Key words Rat forebrain ; Reperfusion ; Cytokine ; Intercellular adhesion molecule-1 ; Chemokine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cellular damage secondary to reperfusion following ischemic insult has been hypothetically attributed to an inflammatory cascade concerted by cell-to-cell interactions. While the role of several cytokines and adhesion molecules in reperfusion injury of the brain has been explored to a certain extent, their regulatory and temporary profiles remain unclear. We have addressed the temporal features of the induction of mRNA for proinflammatory cytokines, adhesion molecules and chemokines at an acute phase subsequent to reperfusion in rat forebrain. Semiquantitatively calibrated reverse transcription-polymerase chain reaction analysis was employed to assess the relative expression of mRNA for intercellular adhesion molecule (ICAM)-1, interleukin (IL)-1α, IL-1β, IL-2, IL-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, monocyte-chemoattractant protein (MCP)-1, and macrophage migration inhibitory factor (MIF). The increase in mRNA from the basal levels after reperfusion followed one of two different patterns; an increase occurring as early as 1 h, or a slight increase continuing up to 24 h after reperfusion. The former pattern was seen for ICAM-1, IL-1α, IL-1β, TNF-α, and MCP-1, and the latter for IL-6 and MIF. These results were consistent with the proinflammatory properties of the immediately induced cytokines, which may be involved in the initiation step of the inflammatory cascade, causing the secondary cellular responses and finally leading to further brain damage.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 135 (1995), S. 163-170 
    ISSN: 0942-0940
    Keywords: Anaplastic ependymoma ; tumour suppressor gene p53
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We analyzed seven cases of anaplastic ependymoma, focusing on neuro-imaging, histopathology, and mutations of the tumour suppressor gene p53. Five of the seven tumours were supratentorial. All had both cystic and solid components, with fragment calcifications detectable on CT scan. The solid parts of the tumours were imaged as heterogenous hypo- or iso-intense areas with moderate enhancement on T1-weighted magnetic resonance images. Vascularity was not prominent on angiograms except for one case. Histologically, in addition to the WHO criteria, loss of typical cellular architecture, endothelial proliferation, and necrosis were commonly found. A mutation in Exon 5 of the tumour suppressor gene p53 was detected in one anaplastic ependymoma out of five tumours (two benign and three anaplastic ependymomas) examined by PCR-SSPC analysis of genomic DNA followed by direct sequencing. Anaplastic ependymoma typically presents as a calcified cystic tumour in the supratentorial parenchyma or transependyma. Mutations of p53 deserve further investigation to examine their possible role in the oncogenesis and malignant transformation of ependymoma.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 0942-0940
    Keywords: Keywords: Premature rupture; cerebral aneurysm; microsurgery; temporary clipping.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ The causes and management of intra-operative premature rupture are analysed and discussed.  During the past 6 years, the authors, performed 398 consecutive direct surgical interventions for ruptured cerebral aneurysms. Intra-operative premature rupture is defined as a rupture which occurs before the securing of the parent arteries or the neck of the aneurysm and is out of control, at least temporarily. The causes and management were retrospectively analysed by reviewing video tape recordings.  Intra-operative premature ruptures which met the above definition occurred in 24 cases (6.0%). The causes were as follows: 1.) dural opening and arachnoid opening (8.3%), 2.) haematoma removal (12.5%), 3.) brain retraction (16.7%), 4.) aneurysm dissection (62.5%). A double suction technique was used to control bleeding and haemostasis with a small piece of cotton or a temporary clip, performed in 20 cases (83.3%). However, in cases with premature rupture immediately after the dural or arachnoid opening, the extension of the haematoma into the subarachnoid space resulted in severe brain swelling and partial resection of the brain had to be done to secure temporary clipping. The double suction technique and primary haemostasis using a small piece of cotton or temporary clip resulted in good outcome even in cases with premature rupture. However, very early premature rupture also occurred although its incidence was extremely rare. The removal of part of the brain can secure the working space but the outcome was poor.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 47 (1979), S. 37-44 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We review 36 patients with recurrent attacks before radical surgery during hospitalization and evaluate various factors which seem to contribute to the recurrence of haemorrhage.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 141 (1999), S. 161-164 
    ISSN: 0942-0940
    Keywords: Keywords: Subarachnoid haemorrhage; cerebral aneurysm; inhaled anaesthesia; intravenous anaesthesia.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  To investigate the clinical effects of intravenous anaesthesia on surgical procedure and the outcome in acute stage surgery for aneurysmal subarachnoid haemorrhage (SAH), pre-, intra-, and post-operative factors were analyzed to compare between inhalational (IA, n=38) and intravenous (IVA, n=37) anaesthesia. IVA significantly shortened the duration of surgery (p〈0.05) and the duration of hospital stay (p〈0.01). These results suggest that IVA may be more suitable than IA for acute stage surgery of aneurysmal SAH. These effects may be mainly caused by IVA's pharmakokinetics, by effects on intracranial homeostasis and metabolism, and neuroprotective properties.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 0942-0940
    Keywords: Keywords: Pineal region tumour; endoscope; navigation; surgery.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Object. To determine the efficacy and accuracy of surgically-assisted systems including endoscopy combined with neuronavigation in the treatment of pineal region tumours through the occipital transtentorial approach, an evaluation of thirty-one patients undergoing surgery was performed over a 10-year period.  Method. The study was performed in 2 parts. The surgical approach to the pineal region was the same in the two parts, but in part 2 a smaller craniotomy window was used. Part 1 (from March 1989 to March 1997) included 15 patients who underwent surgical removal of pineal region tumours without using assisted systems; four out of the fifteen patients had surgery-related complications, including seizure and hemianopsia. Part 2 (from April 1997 to February 1999) included 16 patients who underwent surgical treatment by the same surgical team and with assisted systems; all 16 patients had excellent outcomes, with no complications.  Conclusions. Although this study was the first specifically to examine the efficacy of endoscopy combined with neuronavigation in the treatment of pineal region tumours, our findings suggest that these systems are very useful, safe, and accurate in evaluating the primary tumour and surrounding anatomy as well as in determining operative strategy, such as the location and size of the scalp incision, craniotomy, and the extent of surgical removal. Therefore, we conclude that the addition of endoscopy combined with neuronavigation to standard surgical procedures can improve the outcome of surgical treatment of pineal region tumours.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...