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  • Articles: DFG German National Licenses  (10)
  • 1995-1999  (10)
  • 1
    Electronic Resource
    Electronic Resource
    Development of a 2.45 GHz electron cyclotron resonance ion source for ion-implanter application : Proceedings of the 7th international conference on ion sources (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 837-839 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A compact electron cyclotron resonance (ECR) ion source has been designed at 2.45 GHz microwave frequency for ion implanter and is being tested. The design is based on a straightforward application of the method adopted for conventional ECR ion sources for multiply charged ions: a closed ECR surface completely contained in the plasma chamber. Initial tests have shown a promising indication: a total current of about 7 mA of Ar ions has been extracted at 25 kV extraction voltage. Design features and preliminary performance are reported. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1148542
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  • 2
    Electronic Resource
    Electronic Resource
    Summary of 12th international ECRIS workshop [1995] (invited)a) (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 1606-1613 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The 12th international workshop on electron cyclotron resonance ion sources (ECRIS), held on 25–27 April 1995, is summarized from the following points of view: (1) steady improvement of performance, (2) better understanding of the physical processes upon which ECR ion sources are based, (3) active pursuit for better performance by using higher magnetic field and devising new technologies, and (4) expanding application of ECRIS for highly charged ions. The upper limit of performance has not been foreseen and further improvement can be expected. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1146914
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  • 3
    Electronic Resource
    Electronic Resource
    First operation of HiECR-3 ion source for 14–18 GHz : Proceedings of the 6th international conference on ion sources (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 1186-1188 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The new HiECR-3 ion source has been designed to have a mirror field and a hexapole field strong enough for both 14 and 18 GHz operation. We designed, manufactured, and operated the HiECR-3, for studying characteristics of volume and surface dependence on the electron cyclotron resonance (ECR) plasma zone. From these measurements of the ECR plasma, we examined many problems. They are the ECR plasma zone, the extraction efficiency from the plasma zone, electron injection from another ECR plasma zone, and volume and surface of the ECR plasma zone. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1146727
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  • 4
    Electronic Resource
    Electronic Resource
    Status of ion sources for the Heavy Ion Medical Accelerator HIMAC : Proceedings of the 6th international conference on ion sources (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 962-964 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences (NIRS) is the first heavy-ion accelerator complex dedicated to cancer therapy. HIMAC is equipped with two kinds of ion sources. The PIG ion source is an indirectly heated cathode type, which is operated with a very low-duty factor. The ECR ion source has a single closed ECR zone with 10 GHz microwaves. Both sources realize good stability and reproducibility with easy operation, and satisfy the requirements for radiotherapy. They have been successfully used for clinical trials since June of 1994, and several tens of cancer patients have already been treated with 290–400 MeV/u carbon beams. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1146784
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  • 5
    Electronic Resource
    Electronic Resource
    Summary of 12th international ECRIS workshop [1995] (invited) (abstract)a) : Proceedings of the 6th international conference on ion sources (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 882-882 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The 12th international workshop on electron cyclotron resonance ion sources (ECRIS), held on 25–27, April 1995, is summarized from the following points of view: (1) steady improvement of performance, (2) better understanding of the physical processes upon which ECR ion sources are based, (3) active pursuit for better performance by using higher magnetic field and devising new technologies, and (4) expanding application of ECRIS for highly charged ions. The upper limit of performance has not been foreseen and further improvement can be expected. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1147234
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  • 6
    Electronic Resource
    Electronic Resource
    Closed intramedullary osteotomy for rotational deformity after long bone fractures (1997)
    Springer
    International orthopaedics 20 (1997), S. 346-349 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Dix patients avec un cal vicieux en rotation du fémur ou du tibia ont fait l’objet d’une correction par une ostéotomie intramédullaire à foyer fermé. Il y avait 9 hommes et une femme. L’âge moyen est compris entre 18 et 56 ans. Huit patients présentaient un cal en rotation externe du fémur et les deux autres avaient un tibia déformé. Le cal vicieux en rotation variait de 30 à 60 degrés et était associéà un raccourcissement de 15 à 30 mm dans 6 cas. Toutes les ostéotomies de dérotation ont été réalisées par section intramédullaire et fixées par clou verrouillé. Le raccourcissement a été corrigé dans le même temps opératoire. Le plus récent contrôle des patients montre que la déformation résiduelle est moins que 5 degrés et le raccourcissement de moins de 15 mm. Tous les patients étaient satisfaits de la longueur et la mobilité du membre inférieur opéré. Il n’y eut aucune complication per- ou postopératoire sauf un retard de consolidation. Dans ce dernier cas, la consolidation fut obtenue à 2 ans sans intervention supplémentaire. L’ostéotomie intramédullaire est la fa*on la plus sûre d’obtenir la correction d’un cal vicieux rotatoire d’un os long, avec un taux de complication minimal.
    Notes: Summary. Ten patients with rotational deformities after fractures of the femur or tibia were treated by closed intramedullary osteotomy. Eight had an external rotation deformity of the femur and 2 had deformities of the tibia. The rotational deformity varied from 30° to 60° and 6 patients had shortening of 15 mm to 30 mm. The osteotomies were carried out with an intramedullary saw and were fixed by an interlocking nailing. Shortening was corrected at the same time. At follow up the average rotational deformity was less than 5° and shortening less than 15 mm. All the patients felt that they had a normal range of movement and equal length. There were no complications, except for one case of delayed union in which consolidation occurred at 24 months without any further procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002640050094
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  • 7
    Electronic Resource
    Electronic Resource
    Effect ofmutY andmutM/fpg-1 mutations on starvation-associated mutation inEscherichia coli: implications for the role of 7,8-dihydro-8-oxoguanine (1996)
    Springer
    Molecular genetics and genomics 251 (1996), S. 352-357 
    Details
    ISSN: 1617-4623
    Keywords: mutY ; mutM ; Escherichia coli ; 8-Hydroxyguanine ; Starvation-associated mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract MutY specifies a DNA glycosylase that removes adenines unnaturally paired with various bases including oxidized derivatives of guanine, such as 7,8-dihydro-8-oxoguanine (8-oxoG). The rate of mutation in starvedEscherichia coli cells is markedly raised inmutY mutants defective in this glycosylase. As predicted, the mutations produced include G to T transversions. Bacteria carryingmutM orfpg-1 mutations (defective in Fapy glycosylase, which removes oxidized guanine residues such as 8-oxoG) show little or no enhancement of mutation under starvation conditions. When present together withmutY, however,mutM clearly further enhances the rate of mutation in starved cells. Plasmids resulting in overproduction of MutY or Fapy glycosylases reduce the rate of mutation in starved cells. We conclude that, in non-growing bacteria, oxidized guanine residues, including 8-oxoG, constitute an important component of spontaneous mutation. Addition of catalase to the plates did not reduce the mutant yield, indicating that extracellular hydrogen peroxide is not involved in the production of the premutational damage. Singlet oxygen, known to give rise to 8-oxoG, may be the ultimate oxidative species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02172526
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  • 8
    Electronic Resource
    Electronic Resource
    Requirement for two conserved cysteine residues in the Ada protein ofEscherichia coli for transactivation of theada promoter (1996)
    Springer
    Molecular genetics and genomics 250 (1996), S. 523-532 
    Details
    ISSN: 1617-4623
    Keywords: Adaptive response ; Alkylating agent ; Methylation ; O6-Methylguanine DNA methyltransferase ; Zinc protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Cysteine residue 69 of theEscherichia coli Ada transcription factor, which accepts a methyl group from methylphosphotriester in methylated DNA, was substituted by each of 19 other amino acids. Only the mutant Ada (C69H), carrying a histidine substitution of Cys69, exhibited a limited degree of transactivating potential for theada promoter inE. coli cells although the mutant protein was completely devoid of methylphosphotriester-DNA methyltransferase activity. Using a multicopy plasmid system for the expression of Ada protein, we have shown that Ada C69H has a transactivating capacity equivalent to that of wild-type Ada protein in the absence of an alkylating agent. This indicates that the zinc-binding capacity of histidine at residue 69 is likely to be sufficient for Ada to recognize and bind to theada promoter. Furthermore, transactivation of theada promoter by Ada C69H was enhanced up to 6-fold by treatment with methylating agents. An additional substitution was made with alanine in Ada C69H, replacing Cys321, the site for acceptance of a methyl group from O6-methylguanine and O4-methylthymine residues in DNA, with alanine. This renders the protein completely inactive as a methyltransferase but this derivative is constitutively active as a transactivator for theada promoter. Therefore, acquisition of a methyl group at Cys321 apparently enhances the transactivating capacity of Ada protein on theada promoter. We propose that the transcription-regulating function of Ada protein is under dual control by methylation of cysteine residues at positions 69 and 321; the former enhances DNA binding, while the latter enhances the transactivating capacity of the protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02174440
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  • 9
    Electronic Resource
    Electronic Resource
    Molecular cloning of AtMMH, an Arabidopsis thaliana ortholog of the Escherichia coli mutM gene, and analysis of functional domains of its product (1998)
    Springer
    Molecular genetics and genomics 259 (1998), S. 577-590 
    Details
    ISSN: 1617-4623
    Keywords: Key wordsmutM ortholog ; 8-oxoguanine ; DNA repair ; Arabidopsis thaliana ; Functional domains
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We isolated and characterized cDNAs and a genomic clone encoding an Arabidopsis thaliana MutM homolog (AtMMH). AtMMH is a single-copy gene spanning about 3 kb in the nuclear genome, and comprises ten exons. The AtMMH gene encodes two types of mRNA (AtMMH-1 and AtMMH-2) formed by alternative splicing of exon 8. Western analysis of a crude extract from leaves of A. thaliana, using polyclonal antibodies against the recombinant proteins, demonstrated the presence in vivo of a single 44-kDa polypeptide that comigrates with the product of in vitro translation of the AtMMH-1 mRNA. AtMMH-1 protein prepared in vitro is able to nick double- stranded oligonucleotides containing 8-oxo-7,8-dihydroguanine (8-oxoG) and to bind such oligonucleotides, as does the Escherichia coli MutM protein, which possesses 8-oxoG DNA glycosylase and apurinic/apyrimidinic (AP) lyase activities. Deletion of six amino acids (PELPEV), which are conserved among all known MutM homologs, from the N-terminal end of the AtMMH-1 protein abolishes its nicking but not its DNA-binding activity, indicating that these residues are essential for catalytic activity. Although the AtMMH-1 protein has a unique structure at its C-terminal end, which consists of alternating repeats of basic and acidic amino acids, this structure is dispensable for activity. However, the adjacent amino acid sequence (residues 268 to 281) is essential for repair activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050851
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  • 10
    Electronic Resource
    Electronic Resource
    Requirement for two conserved cysteine residues in the Ada protein of Escherichia coli for transactivation of the ada promoter (1996)
    Springer
    Molecular genetics and genomics 250 (1996), S. 523-532 
    Details
    ISSN: 1617-4623
    Keywords: Key words Adaptive response ; Alkylating agent ; Methylation ; O6-Methylguanine DNA ; methyltransferase ; Zinc protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Cysteine residue 69 of the Escherichia coli Ada transcription factor, which accepts a methyl group from methylphosphotriester in methylated DNA, was substituted by each of 19 other amino acids. Only the mutant Ada (C69H), carrying a histidine substitution of Cys69, exhibited a limited degree of transactivating potential for the ada promoter in E. coli cells although the mutant protein was completely devoid of methylphosphotriester-DNA methyltransferase activity. Using a multicopy plasmid system for the expression of Ada protein, we have shown that Ada C69H has a transactivating capacity equivalent to that of wild-type Ada protein in the absence of an alkylating agent. This indicates that the zinc-binding capacity of histidine at residue 69 is likely to be sufficient for Ada to recognize and bind to the ada promoter. Furthermore, transactivation of the ada promoter by Ada C69H was enhanced up to 6-fold by treatment with methylating agents. An additional substitution was made with alanine in Ada C69H, replacing Cys321, the site for acceptance of a methyl group from O6-methylguanine and O4-methylthymine residues in DNA, with alanine. This renders the protein completely inactive as a methyltransferase but this derivative is constitutively active as a transactivator for the ada promoter. Therefore, acquisition of a methyl group at Cys321 apparently enhances the transactivating capacity of Ada protein on the ada promoter. We propose that the transcription-regulating function of Ada protein is under dual control by methylation of cysteine residues at positions 69 and 321; the former enhances DNA binding, while the latter enhances the transactivating capacity of the protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02174440
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