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  • Articles: DFG German National Licenses  (3)
  • 1995-1999  (3)
  • Organkonservierung  (2)
  • Cervical spine  (1)
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  • Articles: DFG German National Licenses  (3)
Material
Years
  • 1995-1999  (3)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Langzeitergebnisse von 57 Patienten nach ventraler interkorporeller Spondylodese der unteren Halswirbelsäule (1996)
    Springer
    Der Unfallchirurg 99 (1996), S. 925-939 
    Details
    ISSN: 1433-044X
    Keywords: Schlüsselwörter Ventrale interkorporelle Spondylodese ; Plattenspondylodese ; Luxation ; Key words Anterior interbody fusion ; Plate spondylodeses ; Dislocation ; Cervical spine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: In this retrospective study we present the long-term results in 89 patients who underwent anterior interbody fusion of acute cervical spine injuries in our institution between 1972 and 1983. There were 23 dislocations, 50 fracture-dislocations and 16 burst fractures without significant posterior lesions. Only 20 patients showed no neurologic symptoms. In all 79 patients who were treated initially in our trauma department, closed reduction was performed as soon as possible. No aggravation of the neurologic conditions by this manoeuvre was observed. The mean time between injury and operation was 7 days (range 0 – 110 days). In 79 patients an H-plate or one-third-tubular plate was used, and in 10 patients fusion was performed only by bone grafting according to the technique of Robinson [40]. Severe complications, i. e. persistent instability with kyphosis or sagittal dislocation, were found in only 2 of these 10 patients secondary to technical problems. The radiologic results demonstrated a high fusion rate, with fusion in 78 out of the 79 patients. Of the 79 patients treated with plate spondylodeses, 7 devices had to be removed without loss of correction: 6 owing to loosening and 1 to breakage of the plate. Only in one additional case after early hardware removal because of loosening was a loss of correction detected. Of the original 89 patients, 17 had died of causes unrelated to the operation. The mean age of the surviving 72 patients at the time of injury was 36 years (14 – 83 years). A further 15 patients were lost during follow-up, so that 57 (79%) could be included in the study with a mean follow-up of 11 years, 9 months (10 – 19 years). The functional results were as follows: Active range of motion was limited between 25 and 50%. 40 patients had no pain at rest, 38 only during motion without need for treatment. A significant correlation between pain and fused segments could not be found. Spontaneous fusion and spondylophytes in adjacent motion segments were seen in 27 patients, again without significant correlation to residual pain. No hypermobility of adjacent motion segments in functional X-rays was seen. 46 patients returned to their former work, 7 were not able to work again secondary to the injury, 4 patients received old-age pension. Improvement of the neurologic deficits in the 37 symptomatic patients was observed in 30 cases (81,1%) according to the ``Sunnybrook Cord Injury Scale'' [49]; according to the ASIA Neurological Impairment Scale [5] 25 (67,6%) of them improved of at least 1 degree. No correlation could be found between the interval injury to operation and neurologic improvement. With regard to the early stage of the procedure of anterior interbody fusion for traumatic lesions this study shows promising data with high fusion rates and low morbidity, especially for the combination with plate fixation. Further improved within the last 12 years this method offers an excellent alternative for operative treatment of most acute lower cervical spine injuries. Using devices which are not angle stable, special attention should be given to precise bicortical screw fixation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001130050076
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Preservation of pig liver allografts after warm ischemia: normothermic perfusion versus cold storage (1997)
    Springer
    Langenbeck's archives of surgery 382 (1997), S. 175-184 
    Details
    ISSN: 1435-2451
    Keywords: Lebertransplantation ; Warme Ischämie ; Organkonservierung ; Kalte Konservierung ; Normotherme Perfusion ; Reperfusion ; Liver transplantation ; Warm ischemia ; Organ preservation ; Cold storage ; Normothermic perfusion ; Reperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Warm ischemia is known to induce substantial damage to the liver parenchyma. With respect to clinical liver transplantation, the tolerance of the liver to warm ischemia and the preservation of these organs have not been studied in detail. In isolated reperfused pig livers we proceeded according to the following concept: Livers were subjected to 1 or 3 h of warm ischemia. Subsequently, these organs were preserved by either normothermic perfusion or cold storage (histidine-tryptophan-α-ketoglutarate, HTK) for 3 h each. After storage, liver function was assessed in a reperfusion circuit for another 3 h. Parameters under evaluation were bile flow, perfusion flow, oxygen consumption, enzyme release into the perfusate (creatine kinase, glutamic oxaloacetic transaminase (GOT), lactic dehydrogenase, and glutamic pyruvic transaminase), and histomorphology. Damage to the liver was lowest after warm ischemia of 1 h. The results after cold storage were superior to those after normothermic perfusion (GOT: 3.2±0.3 and 2.6±0.2 U/g liver; cumulative bile production: 14.7±2.1 and 9.4±1 ml, respectively;P〈0.05). In contrast, we found substantial damage at the end of reperfusion in livers undergoing 3 h of warm ischemia under both preservation techniques with severe hepatocellular pyknoses and essentially altered nonparenchymal cells. The results suggest that pig livers undergoing 1 h of warm ischemia and cold storage for 3 h with HTK solution may lead to functioning after transplantation.
    Notes: Zusammenfassung Die Verwendung von Lebern mit einer Vorschädigung durch warme Ischämie zur Transplantation wird kontrovers diskutiert. Im Modell der isoliert reperfundierten Schweineleber wurden nach vorausgegangener warmer Ischämie von 1 oder 3 h die Konservierungskonzepte „kalte Konservierung mit HTK-Lösung (Histidin-Tryptophan-α-Ketoglutarat)“ und „normotherme Perfusion“ für jeweils 3 h verglichen. Während einer 3 stündigen Reperfusion wurden neben einer lichtmikroskopischen Auswertung Gallefluß, Perfusionsfluß, Sauerstoffverbrauch und Enzymfreisetzung (Creatin-Kinase, Glutamat-Oxalacetat-Transaminase, Glutamat-Pyruvat-Transaminase und Laktat-Dehydrogenase) gemessen. Nach 1 stündiger warmer Ischämie führte die kalte Konservierung im Vergleich zur normothermen Perfusion zu einer geringeren Schädigung (GOT: 3,2±0,3 und 2,6±0,2 U/g Leber; Gesamtgallefluß: 14,7±2,1 und 9,4±1 ml;P〈0,05). Nach einer warmen Ischämie von 3 h waren bei beiden Konservierungsverfahren die Veränderungen erheblich. Die lichtmikroskopische Untersuchung zeigte Pyknosen von Hepatozyten und sinusoidalen Zellen mit teilweiser Auslösung aus dem Zellverband. Die Ergebnisse belegen, daß im Modell der isoliert reperfundierten Schweineleber eine warme Ischämie von 1 h toleriert wird. Für die Konservierung dieser vorgeschädigten Organe kann das Konzept der hypothermen Konservierung mit HTK-Lösung für einen Zeitraum bis zu 3 h empfohlen werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02391863
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Preservation of pig liver allografts after warm ischemia: normothermic perfusion versus cold storage (1997)
    Springer
    Langenbeck's archives of surgery 382 (1997), S. 175-184 
    Details
    ISSN: 1435-2451
    Keywords: Schlüsselwörter Lebertransplantation ; Warme Ischämie ; Organkonservierung ; Kalte Konservierung ; Normotherme Perfusion ; Reperfusion ; Key words Liver transplantation ; Warm ischemia ; Organ preservation ; Cold storage ; Normothermic perfusion ; Reperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Warm ischemia is known to induce substantial damage to the liver parenchyma. With respect to clinical liver transplantation, the tolerance of the liver to warm ischemia and the preservation of these organs have not been studied in detail. In isolated reperfused pig livers we proceeded according to the following concept: Livers were subjected to 1 or 3 h of warm ischemia. Subsequently, these organs were preserved by either normothermic perfusion or cold storage (histidine-tryptophan-α-ketoglutarate, HTK) for 3 h each. After storage, liver function was assessed in a reperfusion circuit for another 3 h. Parameters under evaluation were bile flow, perfusion flow, oxygen consumption, enzyme release into the perfusate (creatine kinase, glutamic oxaloacetic transaminase (GOT), lactic dehydrogenase, and glutamic pyruvic transaminase), and histomorphology. Damage to the liver was lowest after warm ischemia of 1 h. The results after cold storage were superior to those after normothermic perfusion (GOT: 3.2±0.3 and 2.6±0.2 U/g liver; cumulative bile production: 14.7±2.1 and 9.4±1 ml, respectively; P〈0.05). In contrast, we found substantial damage at the end of reperfusion in livers undergoing 3 h of warm ischemia under both preservation techniques with severe hepatocellular pyknoses and essentially altered nonparenchymal cells. The results suggest that pig livers undergoing 1 h of warm ischemia and cold storage for 3 h with HTK solution may lead to functioning after transplantation.
    Notes: Zusammenfassung Die Verwendung von Lebern mit einer Vorschädigung durch warme Ischämie zur Transplantation wird kontrovers diskutiert. Im Modell der isoliert reperfundierten Schweineleber wurden nach vorausgegangener warmer Ischämie von 1 oder 3 h die Konservierungskonzepte ,,kalte Konservierung mit HTK-Lösung (Histidin-Tryptophan-α-Ketoglutarat)`` und ,,normotherme Perfusion`` für jeweils 3 h verglichen. Während einer 3 stündigen Reperfusion wurden neben einer lichtmikroskopischen Auswertung Gallefluß, Perfusionsfluß, Sauerstoffverbrauch und Enzymfreisetzung (Creatin-Kinase, Glutamat-Oxalacetat-Transaminase, Glutamat-Pyruvat-Transaminase und Laktat-Dehydrogenase) gemessen. Nach 1 stündiger warmer Ischämie führte die kalte Konservierung im Vergleich zur normothermen Perfusion zu einer geringeren Schädigung (GOT: 3,2±0,3 und 2,6±0,2 U/g Leber; Gesamtgallefluß: 14,7±2,1 und 9,4±1 ml; P〈0,05). Nach einer warmen Ischämie von 3 h waren bei beiden Konservierungsverfahren die Veränderungen erheblich. Die lichtmikroskopische Untersuchung zeigte Pyknosen von Hepatozyten und sinusoidalen Zellen mit teilweiser Auslösung aus dem Zellverband. Die Ergebnisse belegen, daß im Modell der isoliert reperfundierten Schweineleber eine warme Ischämie von 1 h toleriert wird. Für die Konservierung dieser vorgeschädigten Organe kann das Konzept der hypothermen Konservierung mit HTK-Lösung für einen Zeitraum bis zu 3 h empfohlen werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008039
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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