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  • 11
    Electronic Resource
    Electronic Resource
    Electrophysiological characterization of histamine receptor subtypes in sheep cardiac Purkinje fibres (1992)
    Springer
    Inflammation research 36 (1992), S. C325 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The histamine-receptor subtype mediated effects on action potentials of electrically driven and spontaneously active isolated sheep cardiac Purkinje fibres were investigated using H1-and H2-selective agonists and antagonists. In electrically stimulated Purkinje fibres histamine (3 μmol/l) increased action potential plateau height, decreased action potential duration at −60mV, and enhanced pacemaker activity. These effects were abolished by 30 μmol/l cimetidine (H2-selective antagonist), but not impaired by 0.3 μmol/l dimethindene (H1-selective antagonist). In spontaneously active Purkinje fibres, histamine (10 μmol/l) increased the spontaneous rate by 24%, the slope of diastolic depolarization by 45% and shortened the duration of the diastole at −60mV by 32% of the respective control measurements. These effects were blocked by 30 μmol/l cimetidine, but not by 0.3 μmol/l dimethindene. The concentration-response relationship of histamine was shifted to higher histamine concentrations by approximately 2 logarithmic units in the presence of 30 μmol/l cimetidine, but no displacement was found in the presence of 0.3 μmol/l dimetindene. The H2-selective agonist impromidine (0.001–0.3 μmol/l) has similar actions to histamine on spontaneously active Purkinje fibres, while the H1-selective agonist 2-(2-pyridyl-)ethylamine was ineffective. It is concluded that the pronounced stimulatory action of histamine on spontaneous activity in sheep cardiac Purkinje fibres is exclusively mediated by H2-receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997364
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  • 12
    Electronic Resource
    Electronic Resource
    Electrophysiological characterization of histamine receptor subtypes in sheep cardiac Purkinje fibers (1992)
    Springer
    Inflammation research 37 (1992), S. 30-38 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The histamine-receptor-subtype-mediated effects on action potentials of electrically driven and spontaneously active isolated sheep cardiac Purkinje fibers were investigated using H1-and H2-selective agonists and antagonists. In electrically stimulated Purkinje fibers, histamine (3 μmol/l) increased the action potential plateau height, decreased the action potential duration measured at a repolarization level of −60 mV and enhanced the pacemaker activity. These effects were abolished by the H2-selective antagonist cimetidine (30 μmol/l), but were not impaired by the H1-selective antagonist dimetindene (0.3 μmol/l). In spontaneously active Purkinje fibers, histamine (10 μmol/l) increased the spontaneous rate by 24%, the slope of diastolic depolarization by 45% and shortened the duration of the diastole by 32% of the respective control measurements. These effects were blocked by 30 μmol/l cimetidine, but remained unchanged in the presence of 0.3 μmol/l dimetindene. Concentration-response curves of histamine were shifted to the right by approximately 2 logarithmic units in the presence of 30 μmol/l cimetidine, but were not influenced in the presence of 0.3 μmol/l dimetindene. The H2-selective agonist impromidine (0.001–0.3 μmol/l) had similar actions as histamine on spontaneously active Purkinje fibers, while the H1-selective agonist 2-(2-pyridyl-)ethylamine was ineffective. It is concluded that the pronounced stimulatory action of histamine on spontaneous activity in sheep cardiac Purkinje fibers is exclusively mediated by H2 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01987887
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  • 13
    Electronic Resource
    Electronic Resource
    Multiplicity and pseudorapidity distributions of charged particles from32S induced heavy ion interactions at 200A GeV (1992)
    Springer
    The European physical journal 55 (1992), S. 539-548 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Multiplicity and pseudorapidity distributions have been measured for32S+Al, Cu, Ag and Au at 200A GeV. The widths of the pseudorapidity distributions increase from central to peripheral collisions. The main contribution is assumed to come from the increasing fraction of charged particles stemming from the fragmentation of the target for peripheral collisions as compared to central collisions. On the average 170–180 charged particles per unit of pseudorapidity are attained for the most central32S+Au events at the maximum of the distribution. The target dependence of the yield of charged particles for central collisions is investigated. In the target rapidity region the yield is directly proportional to the target mass. The transverse energy per charged particle has been studied as a function of centrality and pseudorapidity. The experimental results are compared to the results from the Monte-Carlo model VENUS 3.11 which includes rescattering among secondaries. A comparison between different centrality triggers is made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01561291
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  • 14
    Electronic Resource
    Electronic Resource
    Bose-einstein correlations in the target fragmentation region in 200A GeV16O+nucleus collisions (1992)
    Springer
    The European physical journal 53 (1992), S. 225-237 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Correlations between positive pions are investigated in the target fragmentation region of 200A GeV16O+nucleus collisions. The pions are measured with the Plastic Ball detector in the WA80 experiment at the CERN SPS. The target mass dependence of the radii and the correlation strength extracted by interferometry is studied. A new approach to the fit of the correlation function is introduced. The correlation strength and both invariant and transverse radii increase with decreasing target mass. The transverse radius for16O+C reactions appears to be much larger than the geometrical radius of the nuclei involved. For the Au target only a small fraction of the measured pions contributes to the apparent correlation. Hints for a much larger second component in16O+Au reactions are observed. Rescattering phenomena may provide a clue to understand these phenomena.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01597558
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  • 15
    Electronic Resource
    Electronic Resource
    A slowly inactivating transient outward current in rat ventricular myocytes (1993)
    Springer
    Pflügers Archiv 425 (1993), S. 184-186 
    Details
    ISSN: 1432-2013
    Keywords: voltage clamp ; transient outward current ; cardiac myocytes ; tetrodotoxin ; cadmium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In rat ventricular myocytes we found two components of transient outward current, which could be discriminated time- and voltage-dependently. Besides the well known fastly inactivating transient outward current (ito,f, τ=35±8ms, n=4) we investigated properties of a slowly inactivating transient outward current (ito,s, τ=1.7±0.4s, n=4). Because of the slow inactivation process of ito,s tail currents were observed at −25mV. The inactivation curve of ito,f was characterized by a half-inactivation voltage of −58.4±1.4mV and a slope factor of 5.6±0.5mV (n=4). The inactivation curves of ito,s and tail currents were nearly identical but significantly different from the ito,f-curve. Half-inactivation voltages of ito,s and tail currents were −87.5±6mV and −89.1±5mV (n=4), respectively. Slope factors were 10.3±2.9mV and 9.8 ±1.7mV (n=4). The activation gate of ito,s was half-maximally opened at −11.5±2.6mV, and the slope factor was −10.6±1.7mV (n=3). ito,s tail current reversed its direction at −62±3.2mV (n=5). This indicates, that ito,s- current flow is carried mainly by potassium ions. Ito,s- current was not abolished by Tetrodotoxin (TTX) and Cd.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00374522
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  • 16
    Electronic Resource
    Electronic Resource
    Production of slow singly charged fragments in 200 GeV/c hadron nucleus interactions (1993)
    Springer
    The European physical journal 57 (1993), S. 37-42 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Measurements of slow, singly charged fragments in the target rapidity region have been performed for proton and pion induced reactions with various nuclei at 200 GeV/c. Multiplicity, angular and energy distributions are examined and used to study the effects of rescattering in the nuclear medium. Data are compared to a “geometric cascade model” and to simulations with the VENUS 3.11 and the FRITIOF 1.7 Monte Carlo codes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01555736
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  • 17
    Electronic Resource
    Electronic Resource
    Upper limit for thermal direct photon production in heavy-ion collisions at 60 and 200A·GeV (1991)
    Springer
    The European physical journal 51 (1991), S. 1-10 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The production of direct photons has been investigated in reactions ofp and16O projectiles at 60 and 200A·GeV with C and Au nuclei. Photon and π0 spectra have been measured in the pseudorapidity range 1.5≦η≦2.1 for the transverse momentum region 0.4 GeV/c≦p T ≦2.8 GeV/c employing the lead-glass spectrometer SAPHIR. An upper limit of 15% at the 90% confidence level for the direct photon signal relative to the neutral pion production is obtained from the comparison of measured photon spectra with Monte Carlo simulations of the hadronic background based on the reconstructed yield of π0 and η mesons. Consequences for a possible phase transition to a quark-gluon plasma are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01579555
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  • 18
    Electronic Resource
    Electronic Resource
    Transverse energy production in the target fragmentation region in16O-nucleus reactions at 60 and 200A GeV (1990)
    Springer
    The European physical journal 45 (1990), S. 529-537 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Charged pion yields and transverse energies of baryons are measured for the reaction16O+Cu, Ag, Au at 60 and 200A GeV bombarding energy in the target fragmentation region employing the Plastic Ball detector. Only little dependence of the measured quantities on the bombarding energy is found. The data are compared with the multi-chain fragmentation model of Ranft. As a result it turns out that a leading order formation zone cascade is not sufficient to explain the baryon yield and the transverse energies of baryons in the target fragmentation region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01556265
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