Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Articles: DFG German National Licenses  (18)
  • 1990-1994  (12)
  • 1980-1984  (6)
  • 1
    Electronic Resource
    Electronic Resource
    The Potent Free Radical Scavenger α-Lipoic Acid Improves Cognition in Rodents (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 717 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb12079.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Expression of the HIV-1 Nef protein in the baculovirus system: investigation of anti-Nef antibodies response in human sera and subcellular localization of Nef (1992)
    Springer
    Archives of virology 126 (1992), S. 293-301 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thenef gene of HIV-1 was expressed in insect cells using the eucaryotic baculovirus system. The recombinant Nef protein frequently reacted with seropositive sera of HIV-1 and HIV-2 infected patients. Anti-Nef antibodies in HIV-1 seronegative high risk groups individuals were only occasionally seen. Confocal laser scanning microscopy demonstrated that Nef is present both in the cytoplasm and in the nucleus, indicating that Nef might directly function on gene expression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309702
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Therapeutic concentrations of lithium and carbamazepine inhibit cGMP accumulation in human lymphocytes (1991)
    Springer
    Psychopharmacology 104 (1991), S. 45-50 
    Details
    ISSN: 1432-2072
    Keywords: Lithium ; Carbamazepine ; Guanylate cyclase ; Lymphocytes ; Mechanism of action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although a large variety of biochemical effects have been reported for lithium (Li) and carbamazepine (Cbm), the final molecular mechanism underlying their therapeutic efficacy for recurrent affective disorders is still unknown. The data presented here clearly indicate that therapeutic concentrations of both drugs inhibit sodium nitroprusside-induced accumulation of cGMP in human lymphocytes to about the same extent. The effect is not seen for other antidepressants, and shows pronounced interindividual variations in healthy volunteers. A similar effect of lithium and carbamazepine can also be demonstrated for the cGMP accumulation of central neurons using the model of dissociated cells of the mouse brain. The results are discussed in view of a common mechanism of action of both drugs. Furthermore, it is speculated that the individual sensitivity of the cGMP generating system of human lymphocytes to both drugs might be used to predict therapeutic response or nonresponse of the individual patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244552
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Alterations inras-gene expression and intracellular distribution of protein kinase C in the spongeGeodia cydonium in response to marine pollution (1990)
    Springer
    Marine biology 107 (1990), S. 191-197 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The siliceous spongeGeodia cydonium Jameson was used to study the influence of pollution in marine environments on selected parameters of the intracellular signal transduction pathway. The parameters chosen were: intracellular distribution of protein kinase C (PK-C),ras-gene expression and DNA polymerasealpha (DNA Polalpha) activity. Both PK-C andras-gene product (ras-protein) have previously been established to be key molecules in the intracellular signalling pathway in sponges; increased level ofras-protein mediates events following sponge cell-cell contact. Three unpolluted and three polluted sites in the off-shore seawater around Rovinj (Yugoslavia) were selected for the study in 1989. The state of pollution of these sites has been well-defined in a series of previous studies (1976 to 1989). Transplantation of regenerating sponge cubes ofG. cydonium to the polluted sites resulted in pronounced changes in the parameters chosen, compared to controls exposed to unpolluted environments. Expression ofras gene was increased by three- to five-fold after exposure of regenerating sponge tissue to the impacted sites. At the site with the highest pollutional load,ras mRNA level was about 50% of that at the reference sites. In parallel experiments it was established that, in response to pollution, a translocation of PK-C from the cytosolic to membrane fraction occurred. At the most impacted site, most of the enzyme activity was cytosolic. DNA Polalpha-activity, as a measure of sponge cell proliferation, decreased in a pollutioncorrelated manner. Our results indicate that the intracellular signalling system within sponge cells is activated in response to moderate pollution but is depressed in heavily polluted environments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01319817
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Alloimmune responses between Acropora hemprichi conspecifics: nontransitive patterns of overgrowth and delayed cytotoxicity (1994)
    Springer
    Marine biology 118 (1994), S. 731-737 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Allogeneic interactions between Acropora hemprichi (Ehrenberg) colonies were followed in situ up to 18 mo between 1990 and 1992 in Eilat, Red Sea. We established all 21 possible branch pair combinations among seven large colonies in three to eight replicates each (n=92 pairs), in addition in 14 pairs of grafts within-colonies. All isografts resulted in fusion. Allogeneic interactions revealed a variety of effector mechanisms which involved the appearance of dark blue-purple color in the tissues of interacting branch tips (〈1 cm), unilateral overgrowths (1.0 to 1.5 mm mo-1 for 1 to 8 mo), rejections, healings, continuous overgrowths, reversals, repeated rejections and more. Direction of overgrowth was usually specific to a given combination of colonies. A hierarchial network of overgrowths was obtained by analyzing overgrowth directions of all pairwise combinations, which included 30 transitive and five nontransitive three-way combinations. These outcomes, similarly to responses of allogeneic encounters recorded from other coral species, show that colonies can respond selectively to different types of allogeneic challenges. It is suggested that corals may have the capacity to distinguish self from nonself by recognizing nonself attributes presented on conspecifics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00347522
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Ribonuclease H levels in Herpes simplex virus-infected cells (1980)
    Springer
    Archives of virology 64 (1980), S. 269-275 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two forms of ribonuclease H (RNase H) have been identified both in uninfected and Herpes simplex virus (HSV-)infected BHK cells. Identical RNase H species were detected in control- as well as in infected cells. RNase H I and II have not been found to be associated both with host cell DNA polymerase α and β and HSV-induced DNA polymerase. Infection of BHK cells with HSV type 1 does not lead to a pronounced alteration of RNase H II activity but to an increases (3-fold) of the extractable RNase H I activity. RNase H I activity increases to a maximum between 8–10 hours p.i.; the bulk of HSV-DNA synthesis occurs between 6–8 hours p.i. From these experiments we draw the preliminary conclusion that RNase H I is involved in the degradation of the RNA primer which is covalently linked to newly synthesized HSV-DNA strands.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01322706
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Inhibition of the herpes simplex virus-coded thymidine kinase-complex by 9-β-D-arabinofuranosyladenine 5′-monophosphate (ara-AMP) and 9-(2-hydroxyethoxymethyl)guanine-monophosphate (acyclo-GMP) (1984)
    Springer
    Archives of virology 81 (1984), S. 205-212 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The thymidine kinase-complex isolated from herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) is associated with the following enzyme activities: ATP:dThd (dCyd) deoxypyrimidine kinase, ATP:dTMP thymidylate kinase, ADP:dThd- and AMP:dThd5′-phosphotransferase. In kinetic experiments it is shown that ara-AMP inhibits AMP:dThd- and ADP:dThd phosphotransferase activity, while acyclo-GMP impairs ADP:dThd phosphotransferase reaction only; the inhibition was found to be non-compertitive. The functional subunit ATP:dThd kinase was not affected by either compound.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309993
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Platelet and lymphocyte free intracellular calcium in affective disorders (1994)
    Springer
    European archives of psychiatry and clinical neuroscience 243 (1994), S. 235-239 
    Details
    ISSN: 1433-8491
    Keywords: Intracellular calcium ; Affective disease ; Platelets ; Lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Many studies have demonstrated pharmacologic similarities between platelet and brain 5-HT2 binding sites. Therefore it may be possible to use platelets as a model for the central serotonergic neuron. Accordingly, a previcus report (Kusumi et al. 1991b) about elevated [Ca2+]i after serotonin stimulation in platelets of depressed patients was interpreted as further evidence for enhanced serotonergic sensitivity in depression. However, a very recent study showed an enhanced thrombin-induced platelet Ca2+ response, rather suggesting abnormalities of intracellular Ca2+ regulation in affective disorders. In the present study we have determined 5-HT2-and thrombin-induced Ca2+ responses in platelets and additionally phytohemagglutin (PHA)-induced Ca2+ increase in lymphocytes of medicated depressed patients (8 mono- and 2 bipolar, HRSD〉17) and of ten sex- and age-matched controls. The results showed no significant difference in basal calcium levels between the two groups and no significant difference in the Ca2+ response to thrombin although the response was higher in the patients. The Ca2+ increase after serotonin stimulation in depressed patients was significantly (P〈0.05) higher than in healthy controls. By contrast, the Ca2+ response to PHA in lymphocytes was significantly decreased in the patients. Our data confirm elevated Ca2+ responses after 5-HT2 receptor activation even in medicated depressed patients. However, Ca2+ responses in lymphocytes were decreased. Together with the observations of an enhanced Ca2+ response in platelets after thrombin stimulation, we speculate that the findings rather suggest alterations of [Ca2]i regulation in depression than specific changes of serotonergic sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02191580
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Expression and cellular localization of the Nef protein from human immunodeficiency virus-1 in stably transfected B-cells (1992)
    Springer
    Archives of virology 124 (1992), S. 123-132 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nef protein, encoded by the regulatorynef gene of human immunodeficiency virus type 1 (HIV-1), was expressed in the B-cell line Raji. The cells were stably transfected with plasmids containing thenef transcriptional cassette. They expressed Nef with an Mr of 27,000; the yield could be augmented by incubation with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. The intracellular localization of Nef was analyzed applying immunofluorescence microscopy using a confocal laser scanning microscope. The antigen was stained with a monoclonal antibody directed against the N-terminal part of Nef. The experiments revealed that in non-dividing cells Nef is present both in the cytoplasm and the nucleus while in dividing cells the viral protein is present in the cytoplasm and at the nuclear membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314630
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Cytokine-mediated regulation of monocyte/macrophage cytotoxicity in human immunodeficiency virus-1 infection (1992)
    Springer
    Medical microbiology and immunology 181 (1992), S. 267-281 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Monocyte/macrophage-mediated tumor cytotoxicity was studied in patients infected with human immunodeficiency virus-1 (HIV-1) at various stages [Center for disease control (CDC) classification] of the disease. Using the P-815 tumor cell line as target cells, the results demonstrated reduced monocyte/macrophage cytotoxicity early in HIV-1-related disease (CDCIII, P 〈 0.01). This cellular dysfunction sustained during the progression of the disease. Evidence could be presented that neither exogenous application of macrophage-stimulating cytokines (e.g. interferons) nor their endogenous induction in vitro restored monocyte/ macrophage cytotoxicity. However, enhanced tumor necrosis factor (TNF)-α production, which parallels the observed reduced capacity to lyse P-815 tumor cells, might be the major source for monocyte/macrophage-mediated cell lysis. TNF-α-induced cytotoxicity can be inhibited by addition of anti-TNF-α. Other experimental models using TNF-sensitive tumor target cells may, therefore, mimick monocyte/macrophage-mediated lysis. Suppression of monocyte/macrophage cytotoxicity in later stages of HIV-1 infection (AIDS-related complex, AIDS) could partly be reverted by treatment with the cyclooxygenase blocker, indomethacin. The responsible arachidonic acid product mediating supression was found to be prostaglandin E2, suggesting that in addition to the direct viral interference cellular dysfunction is at least in part a result of altered cytokine regulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198847
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...