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  • Articles: DFG German National Licenses  (9)
  • 1975-1979  (4)
  • 1970-1974  (5)
Source
  • Articles: DFG German National Licenses  (9)
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 29 (1973), S. 103-104 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Das durch Osteosynthese absolut stabilisierte allogene Kompakta-Transplantat zeigt bei dem durch Spenderlymphozyten sensibilisierten Empfänger wider Erwarten einen Knochenumbau, der wesentlich grösser ist als beim Ersttransplantat und dem eines Autotransplantates praktisch gleichkommt.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 2 (1972), S. 231-235 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fractions obtained from Pseudomonas aeruginosa suppressed microcrystal synovitis in pigeons, adjuvant arthritis and experimental allergic encephalomyelitis in rats, the tuberculin reaction in guinea-pigs and the homograft reaction and antibody formation in mice. Products of gram-negative bacteria thus impair nonimmunological inflammatory processes as well as in vivo manifestations of immune-mediated reactions.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 4 (1974), S. 357-363 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ovalicin-semicarbazone suppresses antibody-formation in mice and in other species as measured in the plaque-forming cell and haemagglutination tests. It further impairs cell-mediated immunity as assayed by: homograft reaction and immune cytolysis of tumour target cells in mice, experimental allergic encephalomyelitis in rats, and the tuberculin reaction in guinea-pigs. Although spleen weights are decreased in Ovalicin-semicarbazone treated animals, bone marrow inhibition (as measured by peripheral leukocyte and thrombocyte counts) is only moderate after repeated administration of immunosuppressive doses. Recovery of haemopoietic functions occurs soon after cessation of treatment. The effects of Ovalicinsemicarbazone are compared with those of Ovalicin and azathioprine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aqueous extracts of lymphoid organs were prepared and fractionated by means of gel filtration, ion exchange chromatography, and isoelectric focusing. A protein-containing fraction with a molecular weight of approximately 80,000–90,000 and isoelectric points of 7.6 and 5.3–6.2 was isolated and shown to inhibit reproducibly both thymidine incorporation and proliferation of concanavalin A-stimulated mouse spleen lymphocytes in vitro. This effect appeared specific, since proliferation of mastocytoma P-815 and leukemia L-1210 cells remained unaffected. A small molecular weight fraction (500 to 10,000 daltons) was also found to inhibit lymphocyte proliferation in vitro but was without apparent specificity for cell type.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 4 (1974), S. 277-285 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The primary immune response in 7 inbred and 2 outbred mouse strains to SRBC, tetanus toxin and ‘E.coli’ endotoxin is compared. Significant variations are found in the different strains concerning their antibody response to these antigens. The differences in antibody production reached with SRBC (direct and indirect PFC) and tetanus toxin are on a quantitative level, those with endotoxin also on a qualitative level. The kinetic studies further indicate that course of antibody formation as well as peak of response may considerably vary between different strains.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 6 (1976), S. 468-475 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The fungus metabolite cyclosporin A is a small peptide acting as a novel antilymphocytic agent. It strongly depressed appearance of both direct and indirect plaque-forming cells and produced a clear dose-dependent inhibition of haemagglutinin formation in mice upon oral administration. Skin graft rejection in mice and graft-versus-host disease in mice and rats were considerably delayed by cyclosporin A which also prevented the occurrence of paralysis in rats with experimental allergic encephalomyelitis. This compound was not only highly effective in preventing development of Freund's adjuvant arthritis, but in addition improved the symptoms in rats with established arthritis, although it is inactive in acute inflammation. This new agent contrasts with other immunosuppressives and cytostatic drugs in its weak myelotoxicity. Experimental evidence suggests that cyclosporin A, rather than being cytostatic or lympholytic, affects an early stage of mitogenic triggering of the immunocompetent lymphoid cell.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aqueous extracts of calf and pig lymphoid organs were prepared and fractionated by means of gel filtration, ion exchange chromatography, and isoelectric focusing. These fractions, which had been previously assessed on mitogen-stimulated mouse spleen lymphocytes and other cells in vitro, were tested for their in vivo activity on humoral (haemolytic PFC in mice) and on cell-mediated immunity (skin allograft survival in mice, lymph node weight assay in rats, and systemic GvH-reaction in mice). None of these several fractions elicited either biologically significant or reproducible inhibitory effects. In particular, two fractions, a high and a small molecular weight fraction which were strongly inhibitory in vitro, remained without any chalone-like activity in these in vivo assays. Our results therefore failed to support the existence of a lymphocyte chalone.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 29 (1973), S. 676-678 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Untersuchungen über den Einfluss 20 bekannter Substanzen auf die chemotaktische Wanderung von Kaninchenexsudatzellen, vorab Neutrophilen, werden dargelegt. Im Chemotaxistest nach Boyden wurden die Leukozyten zusammen mit Substanz inkubiert und die Veränderung ihrer gerichteten Wanderungsfähigkeit gemessen. Die Bedeutung der Ergebnisse werden kurz besprochen.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1437-1439 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Chemotaxis of rabbit macrophages was inhibited in vitro by phenylbutazone and sodium salicylate, but not by other antiinflammatory agents. Other inhibitory compounds were colchicine, vincristine, PHA, Con A, iodoacetic acid, cytochalasin B, and EDTA. Some of these in vitro results contrast apparently with in vivo effects.
    Type of Medium: Electronic Resource
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