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  • Articles: DFG German National Licenses  (3)
  • 1975-1979  (3)
  • Guinea pig  (2)
  • Acrodermatitis enteropathica  (1)
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  • Articles: DFG German National Licenses  (3)
Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Perilymphatische Perfusion der Kochlea mit einer Fluorokarbon-Emulsion (1978)
    Springer
    European archives of oto-rhino-laryngology and head & neck 220 (1978), S. 299-301 
    Details
    ISSN: 1434-4726
    Keywords: Fluorocarbon ; O2-Solubility ; Perfusion ; Cochlea ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Because oxygen is at least ten times as soluble in fluorocarbon liquids as in plasma or saline, we investigated the principle possibility of perilymphatic perfusion of the cochlea with perfluortributylamin. Our experiments show that fluorocarbons in spite of the excellent O2-solubility in it are not suitable for the perilymphatic perfusion due to their physical properties (density 1.91 g/ml, non-solubility in water, necessity and difficulties of emulsification).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455367
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Der Verschluß des Aquaeductus cochleae für Perilymphuntersuchungen am Meerschweinchen (1979)
    Springer
    European archives of oto-rhino-laryngology and head & neck 224 (1979), S. 257-265 
    Details
    ISSN: 1434-4726
    Keywords: Guinea pig ; Cochlear aqueduct ; Round window membrane ; Cerebrospinal fluid ; Perilymph ; Protein concentration ; Electrophysiology ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To prevent the perilymph (guinea pig) from contamination with CSF during the sampling the aqueductus cochleae (AC) was blocked by injection of tissue adhesive into the meningeal aperture. The control of an exact blockage of AC was carried out by examination of perilymph-outflow after opening the cochlea (injection of fluorescein-Na into the CSF-space), analysis of perilymphprotein-concentration, macroscopic and microscopic examination of the temporal bones. In all cochleae we have found the same morphological structures, notwith-standing whether the AC was blocked (for a time from 30 min to 7 weeks) or not: The cochlear aqueduct is filled with a mesh of mesenchymal tissue, which grows more dense towards the cochlear aperture and continues into the round window membrane. From scala tympani the AC is always limited by one layer of cells forming a sort of membrane (under light microscope). It seems possible that CSF moves in the inner of the round window membrane between AC and subepithelian space of middle ear mucosa, whereas perilymph of scala tympani is not in direct contact with the flow of CSF. The scala tympanic side of the round window membrane may be a big area for diffusion and there also may be an exchange between CSF and perilymph. The outflow of CSF into the cochlea after experimental opening of the cochlea is an artifact, caused by damage of pressure equilibration between CSF-space and cochlea. 30 min and 5–7 weeks after blockage no morphological and electrophysiological alterations from those of the control ears were to be seen. The protein concentration, however, increased significantly 5–7 weeks after blockage from normally about 200 mg/100 ml to almost the double especially in the scala tympani (see Table 1).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01108783
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Acrodermatitis enteropathica: Recent findings concerning clinical features, pathogenesis, diagnosis and therapy (1976)
    Springer
    European journal of pediatrics 121 (1976), S. 247-261 
    Details
    ISSN: 1432-1076
    Keywords: Acrodermatitis enteropathica ; Small bowel ; Oxyquinoline ; Metabolism of fatty acids ; Paneth cells ; Zinc deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 2 Geschwistern, einem Jungen und einem Mädchen, wurde die Diagnose der Acrodermatitis enteropathica (AE) im Alter von 10 bzw. 6 Wochen gestellt. Bis auf eine Blutsverwandtschaft, die 5 Generationen zurückliegt, ist die Familienanamnese anauffällig. Beide Kinder boten bei Diagnosestellung die für AE typischen Hautveränderungen. Symptome von seiten des Magen-Darm-Kanals waren weniger ausgeprägt und traten mit zunehmendem Alter in den Hintergrund. Bei dem jüngeren Patienten konnten während eines Rezidivs eine Erniedrigung des Serumspiegels der Ölsäure (18:1) sowie eine leichte Vermehrung der Linolsäure (18:2) festgestellt werden, während die Arachidonsäure (20:4) vermindert war. Bei beiden Patienten waren die Serumzinkspiegel mit und ohne Oxychinolinbehandlung deutlich erniedrigt. Eine Substitutionstherapie mit Zinkaspertat brachte weder eine klinische Besserung noch einen wesentlichen Anstieg des Serumzinkspiegels. Durch Gabe von Zinksulfat konnten eine völlige Remission der Hautveränderungen sowie eine weitgehende Normalisierung der Serumzinkspiegel erreicht werden. Untersuchungen der Dünndarmschleimhaut zeigten lichtmikroskopisch keine Besonderheiten. Elektronenmikroskopisch fanden sich in den Enterocyte sogenannte multi-vesicular bodies. Die Paneth-Zellen zeigten teilweise unregelmäßig geformte, inhomogene Strukturen im Cytoplasma. Die pleomorphen Sekretgraula wanen plump und groß und wiesen eine ausgeprägte Heteromorphie ihrer Matrix auf. Da bei Ratten unter zinkarmer Ernährung ähliche ultrastrukturelle Veränderungen bekannt sind, muß durch weitere Untersuchungen geklärt werden, ob die Veränderungen in den Paneth-Zellen typisch für die AE sind. Die adäquate Therapie der AE besteht zur Zeit in der Substitution von Zink. Dadurch wurde die mit toxischen Augenschädigungen belastete Therapie mit Oxychinolinen überflüssig.
    Notes: Abstract Acrodermatitis enteropathica (AE) was diagnosed in 2 siblings, boy and girl, at the age of 10 and 6 weeks. The family history is unremarkable except for consanguinity 5 generations previously. The clinical symptoms of the 2 patients conformed to the known features of AE, the gastrointestinal involvement loosing its significance with increasing age. In one patient in a stage of exacerbation the serum level of oleic acid (18:1) was lowered and of linoleic (18:2) acid slightly increased while that of arachidonic acid was decreased (Fig. 4). In both patients the serum zinc levels were significantly lowered. Under substitution with ZnSO4 the clinical condition improved and the serum zinc levels returned to normal. Histologically the small bowel mucosa was practically normal. Ultrastructural examination of jejunal biopsies revealed rather unspecific changes in the enterocytes in the form of numerous multivesicular bodies. The Paneth cells sometimes contained irregularly formed inhomogeneous structures within their cytoplasm. In addition the secretory granules varied in size and displayed a granular heteromorphic matrix. Frequently they were confluent and formed giant granules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443018
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    Paper (German National Licenses)
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