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  • Articles: DFG German National Licenses  (7)
  • Annonaceae  (4)
  • 5-HT  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Sylvaticin: A new cytotoxic and insecticidal acetogenin fromRollinia sylvatica (Annonaceae) (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 324-327 
    Details
    ISSN: 1420-9071
    Keywords: Sylvaticin ; acetogenin ; Rollinia sylvatica ; Annonaceae ; brine shrimp ; cytotoxicity ; insecticidal ; striped cucumber beetle ; European corn borer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Sylvaticin (I), a new tetrahydroxy annonaceous acetogenin with nonadjacent tetrahydrofuran rings, has been isolated from the dried fruits ofRollinia sylvatica St. Hil. (Annonaceae). This compound is extremely cytotoxic to human tumor cells and shows promising insect control properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951779
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Human platelet 5-hydroxytryptamine receptors: Binding of [3H]-lysergic acid diethylamide (LSD). Effects of chronic neuroleptic and antidepressant drug administration (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 142-145 
    Details
    ISSN: 1420-9071
    Keywords: Platelets ; 5-HT ; LSD binding ; neuroleptics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Chronic treatment with phenothiazines and thioxanthenes has been found to enhance 5-HT-induced aggregation of human platelets. A method has been developed to study 5-HT2 receptor binding sites on platelets utilising [3H]-LSD and more recently125I/LSD. Results are presented which suggest that the LSD binding site is indeed the 5-HT2 binding site and that the LSD binding characterises the specific receptor responsible for 5-HT-induced shape change and aggregation. In a group of patients receiving phenothiazines or thioxanthenes, theB max of LSD binding was increased. The mean binding affinity was decreased possibly due to a persistence of neuroleptic in the platelet membrane preparation. Analysis showed that this was not the reason why the mean binding capacity was increased. The results show that chronic phenothiazine and thioxanthene δ treatment ‘up-regulates’ platelet 5-HT2 binding sites and that this may be accompanied by increased sensitivity to platelet aggregation by 5-HT. In normal subjects desipramine treatment increased theB max of platelet LSD binding and this was accompanied by an increased prolactin response to tryptophan which is thought to be mediated by central 5-HT function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952198
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Annonacin, a novel, biologically active polyketide fromAnnona densicoma (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 947-949 
    Details
    ISSN: 1420-9071
    Keywords: Annonacin ; polyketide ; Annona densicoma ; Annonaceae ; biological activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new linear polyketide, Annonacin (I), has been isolated from active extracts of the stembark ofAnnona densicoma Mart. Annonacin (I) is highly cytotoxic and is active in an assay designed to detect antimitotic agents. The structure of (I) was determined by analysis of spectroscopic data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951681
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Goniothalamicin and annonacin: Bioactive acetogenins fromGoniothalamus giganteus (Annonaceae) (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 83-85 
    Details
    ISSN: 1420-9071
    Keywords: Goniothalamicin ; annonacin ; acetogenins ; Goniothalamus giganteus ; Annonaceae ; brine shrimp ; insecticidal ; cytotoxic ; antileukemic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Using brine shrimp lethality for activity-directed fractionation, goniothalamicin (I), a new tetrahydroxy-mono-tetrahydrofuran fatty acid γ-lactone (acetogenin), has been isolated from ethanolic extracts of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae). This novel compound was found to be cytotoxic and insecticidal and inhibited the formation of crown gall tumors on potato discs. Annonacin (II), the only other reported mono-tetrahydrofuran acetogenin, was also isolated; the previously reported 9ASK (astrocytoma reversal) activity ofII was confirmed, andII is now also found to be weakly active against 3PS murine leukemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01960258
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Gigantecin: A novel antimitotic and cytotoxic acetogenin, with nonadjacent tetrahydrofuran rings, fromGoniothalamus giganteus (Annonaceae) (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 539-541 
    Details
    ISSN: 1420-9071
    Keywords: Gigantecin ; acetogenins ; Goniothalamus giganteus ; Annonaceae ; brine shrimp ; antimitotic ; cytotoxic ; crown gall tumors ; potato disc assay ; 9 ASK
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Gigantecin (I), a novel tetrahydroxy-di-tetrahydrofuran fatty acid γ-lactone (acetogenin), was isolated from an ethanolic extract of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae), by means of activity-directed fractionation (brine shrimp lethality test). This new compound is extremely cytotoxic to human tumor cells, inhibits crown gall tumors on potato discs, and is active in an assay designed to detect antimitotic agents (9 ASK).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954260
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of carbamazepine on 5-hydroxytryptamine function in rodents (1990)
    Springer
    Psychopharmacology 101 (1990), S. 49-53 
    Details
    ISSN: 1432-2072
    Keywords: Carbamazepine ; 5-HT ; Behaviour ; Synthesis ; Release ; Binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of carbamazepine (CBZ) on brain 5-hydroxytryptamine (5-HT) function were investigated in rodents pretreated with CBZ acutely or for 14 days. In behavioural experiments, mice pretreated with 14 days CBZ showed increased 5-HT2-mediated head twitch behaviour after injection of carbidopa (25 mg/kg) followed by 5-hydroxytryptophan (5-HTP, 100 mg/kg). However, no change in head twitches after 5-methoxy,N,N,-dimethyltryptamine (5MeODMT 5.0 mg/kg), a direct agonist, was observed. Chronic CBZ administration to rats did not alter either the behavioural syndrome induced by 8-hydroxy-2-dipropy-laminotetralin (8-OH-DPAT, 1.0 mg/kg), an index of post-synaptic 5-HT1A responses, or hypothermia after 8-OH-DPAT (0.5 mg/kg) which is thought to reflect presynaptic 5-HT1A activity. Both hyperactivity and the behavioural syndrome seen after tranylcypromine (20 mg/kg) followed byl-tryptophan (100 mg/kg) were decreased by prior treatment with CBZ (14 days). Accumulation of 5-HTP after administration of the amino acid decarboxylase inhibitor NSD1015 (100 mg/kg) was decreased after acute CBZ (50 mg/kg) in hippocampus. However, after 14 days oral treatment no change in this measure of 5-HT synthesis was seen, in either hippocampus or frontal cortex. CBZ (50 µM) added to superfused brain slices did not affect potassium-stimulated [3H]-5-HT release. However, hippocampal slices from rats pretreated with CBZ (14 days) showed increased potassium-stimulated [3H]-5-HT release. CBZ (14 days) did not alter 5-HT2 binding in rat frontal cortex. These results indicate a depressant effect of acute CBZ upon presynaptic 5-HT activity and an increase in presynaptic 5-HT function when CBZ is given for 14 days. Post-synaptic 5-HT function was, however, not altered by CBZ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245789
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of 3,N,N′-trimethyl-2-phenyl-1,4-piperazine diastereomers on monoamine uptake and monoamine oxidase in rat brain (1992)
    Springer
    Journal of neural transmission 88 (1992), S. 177-185 
    Details
    ISSN: 1435-1463
    Keywords: Phenylpiperazine ; monoamine uptake ; NA ; DA ; 5-HT ; MAO ; phenylethylamine ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The diastereomers of 3,N,N′-trimethyl-2-phenyl-1,4-piperazine dihydrochloride (TPP) were tested for their effects on NA, DA and 5-HT uptake in synaptosomes prepared from hypothalamus, corpus striatum, and frontal cortex, respectively. The diastereomers differed with respect to their inhibitory properties. (2R, 3R)-TPP was more potent than the other diastereomers on NA and DA uptake, whereas (2S, 3S)-TPP was least potent. In contrast, the (2S, 3S)- and (2 S, 3R)-diastereomers of TPP were more potent than (2R, 3R)- and (2R, 3S)-TPP as inhibitors of 5-HT uptake. None of the diastereomers affected monoamine oxidase activity. The findings show that the diastereomers of TPP interact stereoselectively with neuronal mechanisms for monoamine uptake, and that the (S)-configuration at the 2 carbon is important for inhibitory actions of TPP on 5-HT uptake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244731
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    Paper (German National Licenses)
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