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  • Articles: DFG German National Licenses  (3)
  • Key words Bone marrow transplantation  (2)
  • Bile ducts  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Assessment of the composition of bone marrow prior to and following autologous BMT and PBSCT by magnetic resonance (1996)
    Springer
    Annals of hematology 72 (1996), S. 361-370 
    Details
    ISSN: 1432-0584
    Keywords: Key words Bone marrow transplantation ; Magnetic resonance imaging ; Magnetic resonance spectroscopy ; Therapy monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Lumbar bone marrow was assessed by means of magnetic resonance (MR) in 23 examinations of eight patients who underwent autologous bone marrow transplantation (ABMT) or peripheral blood stem cell transplantation (PBSCT). Various imaging and spectroscopic techniques were applied for measurements carried out prior to conditioning for ABMT/PBSCT and in the course of reconstitution and correlated with clinical and blood chemistry data in these patients. The signal intensity from lumbar bone marrow was determined in T1-weighted and water- and fat-selective MR images. The distribution of the magnetic field was demonstrated by a field-mapping method. Localized proton spectroscopy was performed from volume elements of 2 ml located in the central region of vertebral bodies in order to evaluate the fraction of the water signals, the transverse relaxation times T2 of the signals from water and lipids, and the line widths of the spectral signals. Regions of bone marrow after inflammatory conditions or intensive irradiation are shown to be not involved in marrow reconstitution. Additional information about marrow composition was obtained by the magnetic field mapping and by the line widths in the spectra. Considerable alterations of the amount of paramagnetic hemosiderin were revealed following transplantation. Patients with low water signal and strong local inhomogeneities of the magnetic field in the marrow prior to transplantation had a delayed hematopoietic reconstitution compared with the patients lacking these MR features.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050187
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of bone marrow after transplantation by means of magnetic resonance (1995)
    Springer
    Annals of hematology 70 (1995), S. 3-13 
    Details
    ISSN: 1432-0584
    Keywords: Key words Bone marrow transplantation ; Bone marrow characterization ; Hematopoietic bone marrow ; Hemosiderosis ; Magnetic resonance ; MR imaging ; MR chemical shift imaging ; MR 1H localized spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Magnetic resonance (MR) has become a new tool for noninvasive characterization of bone marrow in patients with hematological disorders in the past few years. Experiences gained from 1H MR imaging and spectroscopic investigations in 48 healthy volunteers and more than 130 patients with hematological disorders are reported and interpreted. Twenty-four of the patients underwent bone marrow transplantation (BMT) before the MR examinations. The findings in these studies provided noninvasive characterization and monitoring of vertebral marrow after BMT. Specifically, MR techniques were found to be suitable for studies of different aspects in physiological and pathological alterations of bone marrow: The water content within the marrow can be analyzed by chemical-shift selective-imaging techniques with good spatial resolution. Spectroscopic methods also allow more sensitive quantification of the signal fractions, as well as separate evaluation of the relaxation times of water and lipids. Relaxometry might be useful to characterize the cellular and extracellular portions of water molecules. Furthermore, the distribution of the magnetic field within small-volume elements of vertebral marrow can be measured. The field distribution is influenced by the trabecular density and the composition of the marrow. High amounts of hemosiderin in the marrow result in clearly broadened field distributions, demonstrated by increasing line widths in MR proton spectra. Magnetic resonance techniques can be used to assess not only the cellularity of the bone marrow, but also metabolic alterations in this compartment which result from cytotoxic treatment or immunological processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715375
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Yamakawa-Prothese mit prolongierter Verweildauer als Therapiekonzept am Beispiel einer benignen biliären Striktur (1998)
    Springer
    Der Chirurg 69 (1998), S. 776-779 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Bile ducts ; injuries ; Bile ducts ; interventional procedure ; Bile ducts ; stenosis or obstruction ; Bile ducts ; stents and prostheses ; Schlüsselwörter: Gallenwegverletzungen ; Gallenwege ; interventionelle Prozeduren ; Gallenwege ; Stenosen und Obstruktionen ; Gallenwege ; Stents und Prothesen.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Ziel: Als Alternative zur operativen Revision einer hohen, benignen biliären Striktur soll das technische Vorgehen der großkalibrigen Gallengangschienung mit Yamakawa-Prothesen ohne repetitive Ballondilatation am Beispiel einer Patientin geschildert werden. Methoden: Zur Stenoseüberbrückung wurde bilateral eine percutan-transhepatische Anlage von 2 Yamakawa-Prothesen aus Silikon vorgenommen (Ductus hepaticus, rechts: 14-F-Prothese; links: 12-F-Prothese). Die Prothesen wurden unter permanentem oralen Antibioticaschutz alle 8 Wochen durch neue Prothesen ersetzt. Nach 8 Monaten wurden beide Prothesen entfernt. Ergebnisse: Die Kontroll-Cholangiographie zeigte ein normal-weites intrahepatisches Gallenwegsystem rechts und eine 50 %ige Mündungsstenose des linken Ductus hepaticus. Die Nachbeobachtung über einen Zeitraum von 18 Monaten zeigte keinen Hinweis auf eine Abflußbehinderung des Gallengangsystems. Schlußfolgerungen: Im Vergleich zur repetitiven Ballondilatation und zur Implantation metallischer Gallenwegstents bietet sich die prolongierte, großkalibrige Schienung benigner biliärer Strikturen mit Yamakawa-Prothesen als alternative Therapieform an.
    Notes: Summary. Aim: As an alternative method to the operative revision of benign bile duct strictures, we report the use of a large-bore bile duct prosthesis (Yamakawa prosthesis) in one patient. Methods: Bilateral percutaneous transhepatic implantation of Yamakawa prostheses (14 F right side, 12 F left side) was performed without adjunctive balloon dilatation. The prostheses were exchanged every 8 weeks under continuous antibiotic treatment and were finally removed after 8 months. Results: Control cholangiography showed a normal intrahepatic biliary system on the right side and a 50 % stenosis at the orifice of the left hepatic duct. Follow-up over 18 months showed no signs of recurrent disease. Conclusions: In comparison to balloon dilatation and implantation of metallic stents, prolonged bilateral splinting with large-bore Yamakawa prostheses seems to be an alternative for the treatment of benign bile duct strictures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050490
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    Paper (German National Licenses)
    Fulltext
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