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  • 1
    Electronic Resource
    Electronic Resource
    A dose escalating study of topotecan preceding cisplatin in previously untreated patients with small-cell lung cancer (2000)
    Springer
    Annals of oncology 11 (2000), S. 829-835 
    Details
    ISSN: 1569-8041
    Keywords: cisplatin ; combination chemotherapy ; phase I ; phase II ; small-cell lung cancer ; topotecan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:The aim was to define the MTD of topotecan (TPT) givenbefore cisplatin in patients with previously untreated SCLC. Patients and methods:Alternating cycles A and B to a total of 6cycles were given. Cycle A: TPT days 1–5 and cisplatin (50mg/m2) day 5. Cycle B consisted of teniposide, carboplatin,vincristine, and cisplatin. TPT was escalated at doses 0.75, 1.0, 1.25, and1.5 mg/m2. DLT was defined for the first cycle as grade 4neutropenia with fever or when lasting 〉7 days, or grade 4thrombocytopenia. Results:Fifteen patients with limited disease and six patientswith extensive disease were included. No episodes of DLT were recorded in thefirst cycles A and consequently 1.5 mg/m2 was defined as MTD. At1.5 mg/m2 (11 patients, 30 cycles), four and three episodes ofgrade 4 thrombocytopenia and neutropenia lasting more than seven days occurredin subsequent cycles A. Thrombocytopenia and anaemia were cumulative as morecycles were administrated. Non-hematological toxicity was mild. The responserate was 86% (95% confidence interval (95% CI):64%–97%) with 33% (95% CI:15%–57%) achieving CR. Conclusions:1.5 mg/m2 TPT can be delivered safely with50 mg/m2 cisplatin on day 5 in patients with previously untreatedSCLC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008393512479
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  • 2
    Electronic Resource
    Electronic Resource
    Phase II study of docetaxel and cisplatin in patients with recurrent or disseminated squamous-cell carcinoma of the head and neck (2000)
    Springer
    Annals of oncology 11 (2000), S. 845-849 
    Details
    ISSN: 1569-8041
    Keywords: cisplatin ; disseminated disease ; docetaxel ; head and neck cancer ; recurrent disease ; squamous-cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:Results with docetaxel as single drug in squamous-cellhead and neck cancer have been encouraging. The purpose of the present phaseII study is to evaluate the antitumour efficacy and toxicity of thecombination of docetaxel and cisplatin in patients with recurrent ordisseminated squamous-cell carcinoma of the head and neck (SCCHN) for whom nocurative therapy is available. Patients and methods:Eligibility criteria included: writteninformed consent; WHO performance status ≤2; age 18–70 years;adequate bone marrow, liver, and renal function; measurable or evaluabledisease; no previous systemic chemotherapy (prior radiotherapy and/or surgerywere allowed); no other previous or concurrent malignancy; no peripheralneuropathy. Treatment consisted of docetaxel 75 mg/m2 in a one-hourinfusion after pre-treatment with prednisolone, followed by cisplatin 75mg/m2 in a half-hour infusion preceded and followed by hydration.Treatment was repeated every three weeks for a maximum of eight cycles. Results:Twenty-five patients (median age 52 years, range33–66) entered the trial, all were evaluable for survival, twenty-fourfor response and toxicity. Twenty-four patients had undergone priorradiotherapy and seventeen had also had surgery. Nineteen had local-regionalrecurrence only, three had local-regional disease and distant metastases, andthree had distant metastases only. Patients received a median of 5 treatmentcycles (range 2–8). Overall response rate was 33% (8 of 24) ofpatients; complete response rate was 8% (2 of 24) of patients, lasting2.2 and 17.1 months, respectively; partial response rate was 25% (6 of24) of patients, lasting for a median of 4.9 months (range 1.7–11.6months). Median survival was 11 months. Toxicity was relatively welltolerated. However, one patient died of probable toxicity (neutropenia andinfection) and three patients discontinued treatment because of toxicity(massive oedema, myocardial infarction, persistent thrombocytopenia). The mostfrequent moderate-to-severe toxicity (75% of patients) was grade3–4 neutropenia, transient in all but one patient. Grade 3 neuropathyoccurred in one patient, none had grade 4. Grade 3 oral mucositis occurred inthree patients, none had grade 4. Grade 2–3 hypomagnesaemia occurred in10 patients requiring magnesium infusion. Conclusions:Docetaxel and cisplatin is an active combination inpatients with recurrent or disseminated SCCHN. Remissions are however fairlyshort. Toxicity is significant, but generally manageable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008355315205
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  • 3
    Electronic Resource
    Electronic Resource
    Darstellung von Komplexsalzen durch doppelte Umsetzung mit Kationenaustauschern (1962)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 74 (1962), S. 466-467 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19620741308
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  • 4
    Electronic Resource
    Electronic Resource
    Synthese von Carbonylazo-Verbindungen durch Reaktion von Alkoxy-diazenium-Salzen mit Carboxylaten (1967)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 79 (1967), S. 681-682 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19670791506
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  • 5
    Electronic Resource
    Electronic Resource
    Electrocatalytical oxidation of glucose on graphite using covalently immobilized glucose oxidase and 1,6-dithia- and 1,6-dioxapyrenes as mediators (1994)
    Weinheim : Wiley-Blackwell
    Electroanalysis 6 (1994), S. 740-745 
    Details
    ISSN: 1040-0397
    Keywords: Glucose ; Enzyme electrode ; 1,6-Dithiapyrene ; 1,6-Dioxapyrene ; Mediator ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Electrocatalytical oxidation of glucose on graphite using new mediators (1,6-dithiapyrenes (DTPs) and 1,6-dioxapyrenes) was performed. The electrocatalysis of glucose oxidase (GO) was based on the dithia(dioxa)pyrene cation-radicals reaction with reduced GO. The rate of reduced GO oxidation by the cation-radical of dithiapyrene was 4.8 × 104 M-1 s-1 at 25°C (pH 7.0). For enzyme electrode preparation, the GO was covalently immobilized by carbodiimide, and the mediator was adsorbed on a graphite electrode. The dithia(dioxa)pyrenes mediated glucose oxidation proceeds at potentials higher than 0.1 V (versus standard calomel electrode (SCE)). Of the investigated substituted dithia(dioxa)pyrenes, the largest electrocatalytical current was observed with electrodes comprising of DTP. Linear calibration graphs of these electrodes were obtained up to 12 mM of glucose, the maximal electrode activity was in the range of pH 6.5 to 8.0, and the temperature coefficient was 5.6%/°C. The investigated electrocatalytical systems can be used for construction of disposable senses for glucose determination in physiological solutions.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140060905
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  • 6
    Electronic Resource
    Electronic Resource
    Methylene-green-mediated carbon paste glucose biosensor (1995)
    Weinheim : Wiley-Blackwell
    Electroanalysis 7 (1995), S. 92-94 
    Details
    ISSN: 1040-0397
    Keywords: Glucose oxidase ; Glucose ; Carbon paste ; Methylene-green mediator ; Enzyme electrode ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An amperometric glucose bioelectrode based on the incorporation of methylene green (MG) within a glucose oxidase (GOD)-containing carbon paste is described. The electrode generates an anodic current in the range of 0.0-0.6 V (vs. SCE). The optimum pH is 8.5. The apparent Michaelis constant for the Cali bration plot is 49.3 mM (at 0.5% MG and 5.0% GOD loadings). The electrode sensitivity is 18.1 μA/mM cm2. The electrode is insensitive to paracetamol and ethanol. At 0.068 V the response to ascorbic acid (40 μM) accounts for 2.4% of that of the normal physiological glucose level in blood. The performance was optimized by systematically altering the electrode composition and electrode potential. The electrode was used to measure glucose in a serum sample and gave an acceptable correlation with the reference method Eksan-G results. Good stability was observed for storage in the dry state in the refrigerator.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140070112
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  • 7
    Electronic Resource
    Electronic Resource
    Neue Umlagerungen von Aryl-allyl-äthern und Allylphenolen. (Vorläufige Mitteilung) (1963)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 46 (1963), S. 2444-2445 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In position 3 (and 5) substituted phenyl-γ-methyl (and phenyl)-allylethers when subjected to the thermal CLAISEN-rearrangement not only yield the expected o-allyl-phenols but in addition considerable amounts of the P-allylated phenols. Migration to the para-position is favoured by non-polar solvents. This para-migration of the substituted allylgroup is attributed mainly to steric factors. With sterically hindered, in ortho- or para-position allylated phenols there was furthermore found an allyl-phenol-rearrangement: on sufficient heating to 200° these substances are transformed to the thermodynamically more stable para- resp. ortho-allylphenols with inversion of the allyl group.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19630460664
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  • 8
    Electronic Resource
    Electronic Resource
    Thermisches Verhalten von o-Dipropenylbenzol, Beispiel einer aromatischen [1,7]-sigmatropischen H-Verschiebung. Vorläufige MitteilungEine ausführliche Mitteilung soll in dieser Zeitschrift erscheinen. (1970)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 53 (1970), S. 173-176 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: cis, cis-, cis, trans- and trans, trans-o-Dipropenylbenzene (cis, cis-, cis, trans- and trans, trans-1) were prepared. At 225° cis, cis-1 isomerises to give cis, trans-1 and vice versa. The isomerisation follows 1. order kinetics. At equilibrium 89% cis, trans- and 11% cis, cis-1 are present. It is shown by deuterium labelling that the isomerisation is due to aromatic [1, 7 a] sigmatropic H-shifts. trans, trans-1 rearranges at 225° to yield 2, 3-dimethyl-1, 2-dihydronaphthalene (3). This can be visualized by disrotatory ring closure of trans, trans-1 followed by an aromatic [1, 5 s] H-shift. When cis, cis- or cis, trans-1 are heated for 153 hrs at 225° a small amount (3%) of 1-ethyl-1,2-dihydronaphthalene (5) is formed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19700530124
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  • 9
    Electronic Resource
    Electronic Resource
    Thermisches Verhalten von Mesitylallenen; Beispiel einer aromatischen [1, 5s]-sigmatropischen H-Verschiebung. Vorläufige MitteilungEine ausführliche Mitteilung soll in dieser Zeitschrift erscheinen. (1970)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 53 (1970), S. 1212-1215 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Mesitylallene (6a), 1-mesityl-3-methyl-allene (6b) and 1-mesityl-3, 3-dimethylallene (6c) were prepared via dienol-benzene-rearrangements. At 170° 6a isomerises to give 5, 7-dimethyl-1, 2-dihydronaphthalene (8). Under the same conditions 6b rearranges to give 2, 5, 7-trimethyl-1, 2-dihydronaphthalene (10; 60%) and cis-1-mesitylbuta-1, 3-diene (11; 40%) while 6c gives only cis-1-mesityl-3-methyl-buta-1, 3-diene (13). The allenes undergo first an aromatic [1, 5 s]-sigmatropic H-shift to the o-xylylene derivatives 7, 9 and 12, which then exhibit disrotatory ring closure to the dihydronaphthalenes or aromatic [1, 7 a]-sigmatropic H-shift to the 1-mesitylbuta-1, 3-dienes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19700530540
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  • 10
    Electronic Resource
    Electronic Resource
    Photochemisches Verhalten von 1- und 2-alkylierten 1,2-Dihydronaphtalinen16. Mitteilung über Photoreaktionen; 14. Mitteilung, s. [1]; 15. Mitteilung, s. [2]. (1971)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 54 (1971), S. 2313-2354 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Irradiation of 1-alkyl-substituted 1,2-dihydronaphthalenes (10, 11, 12) with a lowpressure mercury lamp yields by ring opening ω-vinyl-o-quinodimethanes, which undergo [1, 7] H-shifts to give 1,2-divinyl-benzenes (8, 18, 23; cf. schemes 2, 3 and 4). In a further photoreaction of the divinylbenzenes, benzobicyclo [3.1.0]hex-2-enes (17, 19, 22) are formed. 2-Alkyl-substituted 1,2-dihydronaphthalenes (13, 14, 15, 16) are transformed by irradiation into ω-vinyl-o-quinodimethanes, which show [1, 7] H-shifts to yield in this case 2-(buta-1′, 3′-dienyl)-toluenes (9, 25, 26, 27; cf. schemes 6 and 7). The irradiation of 1-methyl- (10) and 1-ethyl-1, 2-dihydronaphthalene (11) with a high-pressure mercury lamp produces, besides the products of irradiation using the lowpressure lamp, 2-ethyl-allenylbenzene (24), and (from 11) 4-exo-ethyl-benzobicyclo[3.1.0]hex-2-ene (exo-20) and 2-propyl-allenylbenzene (21), respectively (cf. scheme 5). Obviously, these products arise from a photreaction of the primarily formed ω-vinyl-o-quinodimethanes a.
    Additional Material: 18 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19710540771
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