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  • 1
    Electronic Resource
    Electronic Resource
    Response of genetically obese Zucker rats to ciprofibrate, a hypolipidemic agent, with peroxisome proliferation activity as compared to Zucker lean and Sprague-Dawley rats
    Amsterdam : Elsevier
    Biology of the Cell 77 (1993), S. 27-35 
    Details
    ISSN: 0248-4900
    Keywords: Zucker rats ; ciprofibrate ; enzyme induction ; liver ; peroxisomes
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0248-4900(05)80171-6
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Response of genetically obese Zucker rats to ciprofibrate, a hypolipidemic agent, with peroxisome proliferation activity as compared to Zucker lean and Sprague-Dawley rats
    Amsterdam : Elsevier
    Biology of the Cell 77 (1993), S. 27-35 
    Details
    ISSN: 0248-4900
    Keywords: Zucker rats ; ciprofibrate ; enzyme induction ; liver ; peroxisomes
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0248-4900(05)80171-6
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    224Ra and 226Ra experimentally induced dental changes in rats (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 8 (1979), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. Sprague-Dawley rats received intragastrically a single dose of 226Ra or 224Ra once weekly for 21 weeks. During this period the animals of both groups were thus exposed to comparable doses. After 12 weeks, a shortening of the maxillary incisors was observed, and this progressed during the course of the 55–week experiment. Radiologically, a loss of pulpal transparency and an apical irregular opacity in the maxillary incisors were demonstrable. Histologically, dysplastic changes of the maxillary incisors and multiple resorptions at the cemento-enamel junction of the molars were seen. The observed alterations were more pronounced in the 226Ra group than in the 224Ra treated group. The experimentally induced resorptions were comparable to those observed in patients who had incorporated 224Ra or 226Ra. Clinical, radiological, histological, γ-spectrometrical, and autoradiographical findings, as well as dose-estimations, are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1979.tb01822.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cemento-fibrous dysplasia of the periodontal membrane (studies of the European hamster maxillary incisor) (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 15 (1986), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The periodontal membrane of European hamster maxillary incisors showed histologic changes consisting of an irregularly orientated, less vascularized connective tissue which included abundant cementicle-like structures. The changes were multilocal and bilateral, growing towards the alveolar bone (Grade 1), causing atrophy of the alveolar bone due to compression (Grade 2) and reaching the periosteal membranes (Grade 3). In a few animals, the lesions were seen after one year. They were seen in 80% of hamsters more than 2 years old. Carcinogenic exposure did not alter the latency and incidence of the alterations. The lesions were thought to be a spontaneously occurring disease representing a nodular cemento-fibrous dysplasia of the periodontium. As, morphologically, no exact attribution to other odontogenic or mesenchymal growth could be made, the entity of this periodontal lesion was considered. Although the changes observed in the periodontal membrane of the maxillary incisors of the European hamster were not exactly comparable to odontogenic cemental lesions in man, they may serve as a model to further clarify the nature of fibro-osseous lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1986.tb00557.x
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  • 5
    Electronic Resource
    Electronic Resource
    Case report 331 (1985)
    Springer
    Skeletal radiology 14 (1985), S. 216-225 
    Details
    ISSN: 1432-2161
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00355568
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Simultaneous tumors in the respiratory system and urinary bladder of syrian golden hamsters (1974)
    Springer
    Journal of cancer research and clinical oncology 82 (1974), S. 153-158 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die primär multiple Carcinogenese durch DBN wurde systematisch am Modell des Goldhamsters untersucht. Nach subcutaner wie auch nach intragastrischer Gabe fanden sich gleichzeitig Tumoren in Respirationssystem und in der Harnblase. Überlebenszeit, Tumorhäufigkeit und Latenzzeit waren abhängig von der Dosis. Papillome und Plattenepithelcarcinome zeigten sich in den Nasenhöhlen; papilläre Polypen wurden meist in Larynx, Trachea und Stammbrochien beobachtet, in den Lungen fanden sich gemischte und kombinierte Carcinome. Die Harnblase zeigte Übergangsepithelpapillome und -Carcinome.
    Notes: Summary The hamster was used as a model for systematic studies in primary multiple carcinogenesis induced by DBN. After subcutaneous and intragastric treatment, neoplasms were simultaneously found in the respiratory system and in the urinary bladder. A dose dependent effect was seen for survival, tumor incidence and latency. Papillomas and epidermoid carcinomas were found in the nasal cavities; papillary polyps were mainly found in the larynx, trachea and stem bronchi whereas mixed and combined carcinomas were observed in the lungs. The urinary bladder showed transitional cell papillomas and carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284500
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    The influence of hibernation upon the carcinogenic effect of N-diethylnitrosamine in European hamsters (1973)
    Springer
    Journal of cancer research and clinical oncology 80 (1973), S. 285-288 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 120 wild eingefangenen europäischen Feldhamstern (Cricetus cricetus L.) wurde das Carcinogen N-diäthylnitrosamin subcutan verabreicht. 60 Tiere wurden unter Bedingungen des Winterschlafs, die anderen 60 Tiere unter standardisierten Laborbedingungen gehalten. In beiden Gruppen fanden sich Tumoren, vorwiegend im Respirationstrakt. Bei den winterschlafenden Tieren lagen die durchschnittlichen Überlebenszeiten höher und bei insgesamt geringeren Ausbeuten entstanden die Tumoren später.
    Notes: Summary N-diethylnitrosamine (DEN) was given subcutaneously to 120 captured European hamsters (Cricetus cricetus L.). Half of the animals were kept under conditions conducive to hibernation and half under standard laboratory conditions. Neoplasms of the respiratory system were found in both groups. In comparison to nonhibernating animals, the average survival rates for the hibernating animals was increased and the latter developed tumours later and in a lower frequency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284362
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  • 8
    Electronic Resource
    Electronic Resource
    Melanoma in the North of Thailand in the last ten years (1973)
    Springer
    Journal of cancer research and clinical oncology 80 (1973), S. 31-35 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Gewebsproben der Melanomfälle der letzten 10 Jahre aus dem Pathologischen Institut der Universität Chiang Mai, Nord-Thailand, wurden nachuntersucht und soweit erhältlich, die Angaben der Krankengeschichten bei der Auswertung berücksichtigt. Unterschiede hinsichtlich der Lokalisation sowie der Häufigkeit der Melanome in bezug zum Alter und Geschlecht wurden beschrieben. Über 50% der Geschwülste zeigten sich im Bereich der unteren Extremitäten; Männer erkrankten häufiger als Frauen.
    Notes: Summary The cases of melanoma diagnosed at the Chiang Mai University Medical School in the last ten years were histologically re-examined and the case histories, when avalaible, were evaluated. The different anatomical locations of melanoma related to age and sex of the patients were analysed. More than 50% of the melanomas were found on the lower extremities. The frequency of the tumours was higher in males than in females.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285312
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  • 9
    Electronic Resource
    Electronic Resource
    Transplacental effects of nitrosamines in Syrian hamsters (1977)
    Springer
    Journal of cancer research and clinical oncology 90 (1977), S. 71-77 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An Syrischen Hamstern wurde gezeigt, daß sich Nitrosopiperidin (NP) quantitativ nach subcutaner Injektion im mütterlichen Blut für mehr als 8 Std nachweisen läßt, während die Substanz zu diesem Zeitpunkt in Placenta, Fetus und Fruchtwasser nicht mehr meßbar war. In gleichen Geweben fanden sich nur Spuren von N6MI nach 2 Std. Die langzeitige transplacentare Wirkung einer Einzeldosis von NP war schwach. Dies zeigt sich an der geringen Rate von Tumoren im Respirationstrakt (P-Generation: 54%; F1 Generation: 4%). Einige Neoplasmen, die bei den behandelten Müttern nicht gefunden und gewöhnlich nicht bei Kontrollen beobachtet wurden, traten im Verdauungstrakt der Jungen auf. Diese Tumoren wurden als Ausdruck einer transplacentaren Grenzwirkung gewertet. Geschwülste anderer Organe (Urogenitaltrakt, reticulo-endotheliales System, endocrine Organe und andere Gewebe) zeigten Häufigkeitsschwankungen, wie sie in unserer Hamsterkolonie beobachtet wurden.
    Notes: Summary Nitrosopiperidine (NP) was found in Syrian hamsters quantitatively in the maternal blood for more than 8 h after subcutaneous injection, whereas it disappeared from placenta, fetus and amniotic fluid within the same time period. For N6MI, only traces were seen after 2 h in the same tissues. The long-term transplacental effect of a single dose of NP was weak, as demonstrated by a low respiratory tract tumor incidence (P-generation: 54%, F1 generation: 4%). Some tumors occurring in the digestive tract of exposed young were not found in their mothers and not commonly observed in controls. These tumors were considered a borderline transplacental effect. Tumors of other sites (i.e., the urogenital and genital tracts, reticuloendothelial system, endocrine organs and other tissues) corresponded in incidences to the overall fluctuations observed in this hamster colony.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306021
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  • 10
    Electronic Resource
    Electronic Resource
    Urinary bladder neoplasms in Syrian hamsters after administration of N-nitroso-N-methyl-N-dodecylamine (1977)
    Springer
    Journal of cancer research and clinical oncology 90 (1977), S. 227-231 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die biologische Wirkung von N-Nitroso-N-Methyl-N-Dodecylamin (NMDA) wurde bei Syrischen Hamstern in einer vergleichenden Untersuchung geprüft. Die Ergebnisse zeigten, daß nach intragastrischer Verabreichung von NMDA vorwiegend die Harnblase von der carcinogenen Wirkung betroffen ist. Übergangsepithel-Geschwülste entwickelten sich, und eine positive Dosis Wirkungsbeziehung wurde beobachtet. Lungentumoren entstanden nur bei weiblichen Hamstern, während männliche Tiere häufiger Geschwülste der Nasenhöhle und des Verdauungstraktes zeigten.
    Notes: Summary The biological effect of N-nitroso-N-methyl-N-dodecylamine (NMDA) was examined in Syrian hamsters as part of a comparative study. Data obtained show that after intragastric administration of NMDA, the urinary bladder was the main target organ for the carcinogenic effect. Transitional cell neoplasms developed and a positive dose response relationship was observed. Lung tumors occurred only in female hamsters, whereas males more frequently showed neoplasms of the nasal cavity and digestive tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284296
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