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  • Electronic Resource  (5)
  • 1980-1984  (4)
  • 1970-1974  (1)
  • 1982  (4)
  • 1970  (1)
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  • Electronic Resource  (5)
Years
  • 1980-1984  (4)
  • 1970-1974  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    β-adrenoceptor blockade and migraine (1982)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 2 (1982), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Except for propranolol, no other b-blocker has been studied thoroughly in the prophylaxis of migraine. Of those studied, propranolol, atenolol and timolol were shown to be useful in double-blind clinical trials. The mode, or even the site of action of these drugs is unknown. Possible mechanisms of action are peripheral vascular effects, a central action, 5-HT antagonism, an anxiolytic effect and a multifactorial action. The only common property of the successful drugs is lack of partial agonist activity and their profiles do not fully support any of the above hypotheses. Trials of drugs in the prophylaxis of migraine have in general been unsatisfactory due to the difficulty in controlling many variables. b-blockers with differing properties offer an opportunity to define the properties necessary for anti-migraine activity and perhaps shed light on the pathogenesis of migraine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1982.0201033.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Carbon cycle changes of the Zechstein Sea: isotopic transition zone in the Marl Slate (1982)
    [s.l.] : Nature Publishing Group
    Nature 297 (1982), S. 389-390 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] On the basis of measurements of carbon isotopes on rocks of various ages, early models assumed that the mean S13C (carbonate) values were constant3"6. In recent years, however, descriptions of secular variation of S13C values in carbonate rocks during the Mesozoic7'8 and Cenozoic9*10 have ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/297389a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Metabolic studies of taloximine and its effects on the respiratory response to carbon dioxide (1970)
    Springer
    European journal of clinical pharmacology 2 (1970), S. 155-160 
    Details
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Taloximine is a phthalazine derivative with a respiratory stimulant action on the peripheral chemoreceptors. Peak plasma levels of taloximine after oral administration coincided with peak hyperventilation accompanied by a respiratory alkalosis, a, fall in venous pCO2, and a rise in plasma and urinary pH. — Taloximine was excreted in urine and bile. Metabolites included a phthalazinone, demethylated taloximine and other metabolites in ring hydroxylated form. Sulphated and glucuronated taloximine and metabolites were formed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00420343
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of chlorpromazine and other drugs acting on the central nervous system on human sperm motility (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 413-416 
    Details
    ISSN: 1432-1041
    Keywords: chlorpromazine ; sperm motility ; central nervous system depressant ; caffeine ; membrane stabilizing effect ; fertility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The in vitro effects of chlorpromazine, diazepam, phenytoin and phenobarbitone on human sperm motility were investigated. Only chlorpromazine inhibits human sperm motility and the concentration which decreases sperm motility to 50% of control is 0.22 mM. Caffeine can shift the dose-response curve of chlorpromazine-inhibited sperm motility to right. We support the hypothesis that chlorpromazine acts on the cellular membrane but consider the inhibition of sperm motility an unlikely cause of decreased fertility in chlorpromazine treated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542545
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Should erythromycin dose be altered in haemodialysis patients? (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 435-440 
    Details
    ISSN: 1432-1041
    Keywords: erythromycin ; haemodialysis ; dosage adjustment ; pharmacokinetics ; protein-binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Erythromycin kinetics were studied in 17 patients with end stage renal failure treated with maintenance haemodialysis and 9 normal volunteers to discover if dialysis patients needed a modified dose. The elimination half life in dialysis patients (on dialysis days) was similar to that reported in normal subjects. Only small amounts of drug appeared in the dialysate, no patient loosing more than 9 mg in one dialysis. Both patients and volunteers had similar plasma concentrations 8 h after the end of a 5-day course. Protein-binding did not change significantly during dialysis and was similar to that reported in normal subjects. We conclude that dialysis patients requiring 1.5 g of erythromycin stearate daily or less can be given normal doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00605994
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    Paper (German National Licenses)
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