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  • 1
    Electronic Resource
    Electronic Resource
    Evidence for Involvement of p59fyn in Fasting-Induced Thymic Involution (2005)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 62 (2005), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: p59fyn, a member of the src-family protein tyrosine kinase, is expressed abundantly in thymus. We examined the possible involvement of p59fyn in thymic involution induced by a fasting stress in Fyn–/– mice. An acute 48 h fast resulted in severe atrophy of the thymus and a marked decrease of the total thymocyte number with depletion of the CD4+CD8+[double positive (DP)] population in Fyn+/+ (control) mice. A remarkable increase in terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labelling-positive signals was detected in the fasted group of control mice. However, these findings were not observed in Fyn–/– mice. Interestingly, MRL/MPJ-lpr/lpr, a Fas-deficient model animal, also showed no significant decrease of DP cell numbers in the fasted group. p59fyn is known to interact with Fas signalling, and these findings suggest that p59fyn is involved in fasting-induced thymic involution, raising the possibility that Fas/p59fyn-mediated signalling may, at least partially, be associated with the phenomenon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.2005.01646.x
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  • 2
    Electronic Resource
    Electronic Resource
    VERAPAMIL-INDUCED CONTRACTURE IN AN EXCISED, BLOOD-PERFUSED SKELETAL MUSCLE PREPARATION FROM THE DOG (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 10 (1983), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The ability of verapamil to induce a contractile response in skeletal muscle was investigated using the canine isolated, blood-perfused diaphragm preparation.2. Verapamil-induced contracture was characterized by a biphasic increase in muscle tension consisting of an initial phasic and subsequent tonic contracture.3. The second tonic component of the verapamil-induced contracture was inhibited by procaine, but procaine had no effect on the initial phasic contracture.4. Verapamil potentiated both KCl- and caffeine-induced contractures during the second tonic stage. This action might be explained by enhancement by the drug of availability, or by an increased sensitivity of the contractile machinery to calcium liberated by membrane depolarization or by the calcium-induced calcium release mechanism.5. The second tonic component of verapamil-induced contracture was much less than the initial phasic component. It seems, therefore, that the calcium release induced by the procaine-resistant process is the principal action of verapamil in inducing contracture in skeletal muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1983.tb00218.x
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  • 3
    Electronic Resource
    Electronic Resource
    Preventive therapy for non-steroidal anti-inflammatory drug-induced ulcers in Japanese patients with rheumatoid arthritis: the current situation and a prospective controlled-study of the preventive effects of lansoprazole or famotidine (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : There is a lack of evidence for the efficacy of preventive medications for peptic ulcers (PUs) among long-term users of non-steroidal anti-inflammatory drugs (NSAIDs) in Japan.Aim : To estimate the preventive effect by normal dose, not high-dose histamine-H2 receptor antagonists (H2RA) for NSAID-induced ulcers.Methods : We designed two different studies to assess the efficacy of anti-ulcer agents in rheumatoid arthritis (RA) in patients treated over a long term with NSAIDs. An investigative survey divided patients into those not taking anti-ulcer agents (non-medication group); those taking mucosal protective agents (mucosal protectant group), H2RA (H2RA group), proton pump inhibitors (PPI group), or a prostaglandin E1 analog (PG) (PG group). The second study compared prospectively the preventive effects of either famotidine 20 mg bd (famotidine group) or lansoprazole 15 mg daily (lansoprazole group) in patients with PU scars.Results : The prevalence of PU in the H2RA group was significantly lower compared to the mucosal protectant group (P 〈 0.05), and the mucosal protectant group was not significantly different to the non-medication group. The prospective study revealed that the PU onset rate of the famotidine group was 8% (1/13), and lansoprazole group was 15% (2/13), indicating no significant differences between the two.Conclusions : In Japan, normal-dose H2RA is expected to be a new PU preventive treatment strategy in patients requiring long-term NSAID therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02477.x
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  • 4
    Electronic Resource
    Electronic Resource
    Validity of 13C-phenylalanine breath test to evaluate functional capacity of hepatocyte in patients with liver cirrhosis and acute hepatitis (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : No definitive method for quantitative evaluation of hepatic function has as yet been established.Aim : To investigate whether the 13C-phenylalanine breath test would be useful for the evaluation of hepatic function in patients with liver cirrhosis and acute hepatitis.Methods : l-[1-13C]-phenylalanine was administered orally in a dose of 100 mg to 25 patients with liver cirrhosis, 22 patients with acute hepatitis and 10 healthy subjects. The relationships of the cumulative excretion with the 13C-%dose/h, blood biochemical parameters and asialoscintigraphy were investigated.Results : In liver cirrhosis patients, the cumulative excretion showed correlations with hepatic function tests, asialoscintigraphy, clinical stage and portal hypertension. In acute hepatitis patients, the cumulative excretion showed correlations with hepatic function tests. There were positive correlations between the cumulative excretion and the 13C-%dose/h at 20 min (Phe20) and 13C-%dose/h at 30 min (Phe30) in liver cirrhosis and acute hepatitis patients. Multiple regression analysis demonstrated that total bilirubin, total cholesterol and absence of varices were independent determinants of cumulative excretion in liver cirrhosis patients and prothrombin time in acute hepatitis patients.Conclusion : The 13C-phenylalanine breath test may allow hepatic function to be evaluated non-invasively in liver cirrhosis and acute hepatitis patients, and the Phe20 and Phe30 may be useful for determination of function at a single time-point.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02409.x
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  • 5
    Electronic Resource
    Electronic Resource
    On precipitation of metastable centres in solid solutions NaCl–CaCl2 (1954)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 7 (1954), S. 514-515 
    Details
    ISSN: 0001-5520
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0365110X54001636
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  • 6
    Electronic Resource
    Electronic Resource
    On precipitation of metastable centres in solid solutions NaCl–CaCl2 (1954)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 7 (1954), S. 514-515 
    Details
    ISSN: 0001-5520
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0365110X54001636
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  • 7
    Electronic Resource
    Electronic Resource
    Near-infrared spectra of water and aqueous electrolyte solutions at high pressures (1984)
    Springer
    Journal of solution chemistry 13 (1984), S. 811-823 
    Details
    ISSN: 1572-8927
    Keywords: High pressure ; near-infrared spectra ; water ; aqueous electrolyte solutions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The near-infrared spectra (9500 to 11000 cm−1) of pure water and aqueous solutions of alkali halides, MgCl2, NaClO4, and R4NBr were measured at temperatures between 10 and 55°C and pressures up to 500 MPa. From the analysis of the absorption spectra the following conclusions are drawn. (1) The ice I-like open structure is destroyed and the packed structure is formed as the pressure is increased. (2) The open structure of water is destroyed by the addition of alkali halides and MgCl2 and water molecules are restricted around the ions by ion-dipole interactions. This results in a loosening of the O−H bond. (3) The perchlorate ion destroys the open structure of water and the ion-dipole interaction with water is insignificant. (4) The Bu4N+ ion forms water structure around the ion similar to that of the clathrate open structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00647696
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  • 8
    Electronic Resource
    Electronic Resource
    The peristerite gap in low-grade metamorphic rocks (1982)
    Springer
    Contributions to mineralogy and petrology 81 (1982), S. 268-276 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Coexisting Na-plagioclases from greenschists both in the thermal aureole of the Kasugamura Granite, Japan, and in the low-P metamorphic zone of Yap Island, western Pacific were analyzed in great detail; the peristerite solvus was determined for each suite. The asymmetric solvus has steep albite-rich and gentle oligoclase-rich limbs that are similar to those for higher pressure series. The present results together with those from Vermont, New Zealand, and the Sanbagawa belt indicate that the peristerite solvus shifts toward the albite component and higher temperature with increasing pressure. With increasing pressure, albite co-existing with oligoclase (An=100 Ca/Ca+ Na=20) varies in composition from An 8–9 (in Kasugamura), through An 3 (in Yap Island and Vermont), to An 1 (in New Zealand) and An less than 0.5 (in the Sanbagawa belt). The consolute temperatures for the peristerite solvus estimated from available geothermometry are 420° C in Kasugamura, 450–550° C in Vermont and 550°–600° C in the Sanbagawa belt. The variation of plagioclase composition in progressive metamorphic zones is explained by intersection of a plagioclase-forming reaction and the peristerite immiscibility gap in an isobaric T-X An diagram. The greenschist zone is characterized by albite, the transition zone by occurrence of peristerite pairs and the amphibolite zone by plagioclase of An 20–50.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371681
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  • 9
    Electronic Resource
    Electronic Resource
    Fabrication of Carbon Aerogels (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 11-12 (Feb. 2006), p. 19-22 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: RF (Resorcinol-Formaldehyde) aerogels and carbon aerogels were prepared through thesol-gel method following the routes of polymerization, gelation, supercritical drying and pyrolysisprocesses. The influence of fabrication parameters on the textural structure of the samples, e.g.,specific surface area, pore size, and pore size distribution, etc., were systematically investigated. Witha decrease in the R/F molar ratio, or an increase in the catalyst content within a limited range, theporosity of the nanostructure materials increases. The optimal temperature of pyrolysis for RF aerogelwas investigated by TGA (Thermogravimetric Analysis)
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/39/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.11-12.19.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Ultrastructural observation on the thalamic neuronal inclusions in young mice (1983)
    Springer
    Acta neuropathologica 59 (1983), S. 316-318 
    Details
    ISSN: 1432-0533
    Keywords: Intracytoplasmic inclusions ; Thalamus ; Young mice ; Neurofilament
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuronal intracytoplasmic inclusions were found in the ventrolateral and posterior nuclei of the thalamus of 3-month-old thiamine-deficient mice and quaking mice. An electron-microscopic study revealed that these inclusions were composed of condensation of parallel rectilinear 10-nm filaments with interconnecting cross-bridges as a hallmark of neurofilaments. They were morphologically indistinguishable from those described in aged mice. This observation indicates that neuronal inclusions in the thalamus, which have been constantly reported in aging mice, can be seen even in young mice in the presence of cellular metabolic disturbances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691499
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