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  • 1
    Electronic Resource
    Electronic Resource
    Ion sources for large area processing (invited) : The 8th international conference on ion sources (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 1023-1028 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Large area ion sources have been used in ion doping systems in the field of LCD production. In these ion sources good uniformity and wide dynamic range in beam current are both required to achieve the good dose uniformity in wide dose range. A new ion source which uses dc arc discharge with three filaments, each of which is controlled individually, is now in the production lines instead of the conventional rf discharge type. Better than 5% of beam uniformity across 600 mm is achieved by an automated feedback control using beam profile data taken by a built-in beam profiler in less than 10 s from arc ignition. Another emerging requirement is high beam purity, for the ion beams from these ion sources are used without mass analysis. The hydrogen ion fraction was successfully reduced by magnetically retarding the hydrogen ions to less than 5%. A large area ion source having a newly designed mass separating structure is developed. The structure is comprised of a permanent magnet array and a beamlet scanner just after the multiple-slot beam extraction electrode system. All the unwanted ion species in the beam can be eliminated to a good level. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1150377
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  • 2
    Electronic Resource
    Electronic Resource
    Local current distribution in a ferromagnetic tunnel junction measured using conducting atomic force microscopy (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 5206-5208 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The local electrical properties were measured simultaneously with the topography for a Ta(50 Å)/Fe20Ni80(50 Å)/IrMn(150 Å)/Co(50 Å)/Al(13 Å)-oxide junction. The electrical image showed the contrast with around a few nm lateral size and a strong correlation with the topographical image was not observed. In the local current–voltage characteristics, data within the bias voltage of ±1.5 V were fitted well to Simmon's equation and we obtained the barrier height Φ=1.9 eV and the thickness d=12 Å. On the other hand, data with the bias voltages higher than 3 V were fitted well to Fowler–Nordheim equation. The histogram of current density was calculated by taking into consideration a Gaussian distribution of the barrier thickness and the height. The distribution of the barrier height can explain the experimental result realistically. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.373296
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  • 3
    Electronic Resource
    Electronic Resource
    Magnon-assisted inelastic excitation spectra of a ferromagnetic tunnel junction (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 5209-5211 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Inelastic-electron-tunneling spectroscopy (IETS) has been applied to investigate the spin dependent tunneling process for a Ta(50 Å)/Fe20Ni80(60 Å)/IrMn(300 Å)/Co(60 Å)/Al(13 Å)-oxide/ Co(40 Å)/Fe20Ni80(200 Å) spin-valve-type tunnel junction. IET spectra for both parallel and antiparallel magnetization configurations of ferromagnetic electrodes showed a strong peak at 12 mV. The subtraction spectrum defined by the difference between the spectra of both the configurations was calculated. Spin-independent inelastic excitation processes are not affected by an external magnetic field, and thus, the subtraction spectrum indicates the inelastic modes induced only by the magnetic origin. It showed a strong peak at 12 and 20 mV for the positively and negatively biased direction of the bottom electrode, respectively. The tendency of the tunneling magnetoresistance ratio to decrease with bias voltage agreed with the shape of the subtraction spectrum. By assuming the surface magnon excitation, we obtained the distributions of the correlation length and the Curie temperature for both ferromagnetic electrode surfaces faced on the insulator. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.373297
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  • 4
    Electronic Resource
    Electronic Resource
    Spin glass in Fe-Ni Invar alloys (1985)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 57 (1985), S. 3456-3458 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Initial ac susceptibility χ was examined in the temperature range from 4.2 K to Curie temperatures for polycrystalline Fe100−xNix (20≤x≤50) alloys. The reentrant spin glass is found in x=30–45 alloys. The dependence of the freezing temperature Tg on the intensity of driving magnetic field (ac: 0–0.26 Oe; dc: 0–10 Oe) and on the frequency (140–9200 Hz) was studied for the Fe65Ni35 alloy. A strong magnetic relaxation is observed below Tg. These results are discussed based on the cluster model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.335075
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  • 5
    Electronic Resource
    Electronic Resource
    Impaired responses of peripheral blood mononuclear cells to T-cell stimulants in alopecia areata patients with a poor response to topical immunotherapy (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 145 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Topical immunotherapy with a contact allergen is effective in alopecia areata (AA). However, the mechanism of the effect is still unknown, and pretreatment prediction of the outcome of therapy in each patient remains difficult. Objectives  To predict the clinical effect of this therapy in AA patients, we investigated the relationship between clinical responses to topical immunotherapy and in vitro proliferative responses of peripheral blood mononuclear cells (PBMC) to T-cell stimulants. Methods  PBMC were taken from 67 AA patients before or during diphenylcyclopropenone immunotherapy and from 14 healthy controls, and proliferative responses to phytohaemagglutinin and staphylococcal enterotoxin B were evaluated by measuring [3H]-thymidine incorporation. Results  PBMC from the AA patients with a good clinical response to immunotherapy showed a normal level of proliferation, whereas PBMC from the poor responders showed a markedly suppressed proliferative response and interleukin (IL)-2 production, but increased IL-4 production compared with the controls. Conclusions  The proliferative response of PBMC to T-cell stimulants may be one of the indicators of the clinical effect of topical immunotherapy for AA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2001.04398.x
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  • 6
    Electronic Resource
    Electronic Resource
    Interaction of 5-fluorouracil with sodium poly-α,L-glutamate (1985)
    Springer
    Colloid & polymer science 263 (1985), S. 682-685 
    Details
    ISSN: 1435-1536
    Keywords: 5-trifluorouracial ; sodium poly-α ; L-glutamate ; interaction ; viscosity ; 5-trifluoromethyluracil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The purpose of our research is to obtain an understanding of the binding mechanism and its correlations in terms of chemical structure and the potentiactive drug activity. The interaction of 5-fluorouracil (5-fluorouracil is used as an anticancer drug) with sodium poly-α,L-glutamate in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the molar change in enthalpy, entropy and the number of binding sites on the polymer were calculated. It is very interesting that the value ofΔH0 of the binding of 5-fluorouracil with sodium poly-α,L-glutamate is smaller than that of 5-trifluoromethyluracil (although 5-trifluoromethyluracil is not used as an anticancer drug, the compound has a similar structure to 5-fluorouracil).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419893
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  • 7
    Electronic Resource
    Electronic Resource
    Generation of 30 fs pulses at 635 nm by frequency doubling of cavity-dumped chromium-doped forsterite laser, and its application to spectroscopy (2000)
    Springer
    Applied physics 70 (2000), S. S33 
    Details
    ISSN: 1432-0649
    Keywords: PACS: 42.65.Re; 42.55.Rz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. A cavity-dumped Kerr-lens mode-locked chro-mium-doped forsterite (Cr:F) laser was developed. The fundamental frequency of 1270 nm was converted into 635 nm by second-harmonic generation in an LBO crystal. A pulse duration of 30 fs was obtained at 635 nm with energy of 3.8 nJ. The developed laser was applied to single-wavelength pump-probe measurements of dyes, malachite green (MG) and phenol blue (PB).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003400000326
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  • 8
    Electronic Resource
    Electronic Resource
    Familial amyloidotic polyneuropathy (ATTR Ser50Ile): the first autopsy case report (2000)
    Springer
    Virchows Archiv 436 (2000), S. 345-350 
    Details
    ISSN: 1432-2307
    Keywords: Key words Amyloidosis ; ATTR Ser50Ile ; Autopsy ; Familial amyloidotic polyneuropathy ; Transthyretin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report an autopsy case of a pedigree of familial amyloidotic polyneuropathy (FAP) with a mutation of isoleucine-50 transthyretin (ATTR Ser50Ile). A 47-year-old man started developing severe diarrhea and weight loss at age 41 years, followed by urinary incontinence, autonomic-nervous-system abnormalities and serious heart failure; the diagnosis of FAP (ATTR Ser50Ile) was made on the basis of genetic, histochemical and immunohistochemical analysis. Six years after the initial symptoms, he died of septic shock. Autopsy revealed suppurative peritonitis, perforation of the sigmoid colon and marked systemic amyloid deposition. The total amount of amyloid deposited in the heart was greatly increased and was much lower in the thyroid gland and kidneys compared with amyloid deposits in ordinary FAP (ATTR Val30Met). Amyloid deposition in peripheral vessel walls was prominent, particularly in lymphatics and veins. His elder sister, 54 years old, started to develop orthostatic hypotension at age 49 years, followed by dysesthesia, diarrhea and severe congestive heart failure. Endomyocardial biopsy revealed severe TTR–amyloid deposition; ultrastructural examination demonstrated that amyloid fibrils were deposited disproportionately and extended radially around microvessels. These characteristic patterns of systemic amyloid deposition and distinct clinical manifestations, especially in the cardiovascular system, are considered to be a characteristic feature of ATTR Ser50Ile amyloidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050457
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  • 9
    Electronic Resource
    Electronic Resource
    Calpain activates two transglutaminases from porcine skin (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 380-384 
    Details
    ISSN: 1432-069X
    Keywords: Calpain ; Transglutaminase ; Thrombin ; Dimethyl sulfoxide ; Heating
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two transglutaminases (TGase) with estimated molecular weight of 55,000 (55-K TGase) and 120,000 (120-K TGase) were partially purified from the cytosolic fraction of porcine skin (epidermis-rich preparation) using DEAE-cellulose and gel-filtration chromatographies. The enzyme activities of both trans-glutaminases were enhanced more than 20-fold by treatment with calpain (Ca2+-dependent cysteine proteinase) in the presence of Ca2+, and this enhancement was inhibited by adding EDTA, leupeptin, or an endogenous calpain-specific inhibitor protein (calpastatin). 55-K TGase was effectively activated by a smaller amount of calpain than was 120-K TGase, while known activating reagents such as thrombin and dimethyl sulfoxide or heat treatment preferentially activated 120-K TGase. One of the physiological functions of calpain in the epidermis may be the activation of epidermal transglutaminases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426618
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  • 10
    Electronic Resource
    Electronic Resource
    Changes in the lateral ventricle with the head position: Ultrasonographic observation (1988)
    Springer
    Neuroradiology 30 (1988), S. 315-318 
    Details
    ISSN: 1432-1920
    Keywords: Ultrasonography ; Ventricular asymmetry ; Neonate ; Premature infant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrasonographic examination was performed in 13 preterm, 10 normal term and 3 term brain-damaged infants to evaluate changes of the ventricular width with the head position. The lower side of the frontal horn was narrowed and the upper side dilated in all preterm and brain-damaged infants. These changes of the ventricular width may be due to gravity and soft brain. Therefore, it is very important to consider the transformation of the lateral ventricles with the head position when asymmetry of the lateral ventricle is identified in infants showing prematurity or brain damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00328182
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