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  • Electronic Resource  (16)
  • 1995-1999  (9)
  • 1980-1984  (6)
  • 1975-1979  (1)
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  • Electronic Resource  (16)
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  • 1
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary A dermal lymphocytic infiltrate is a characteristic feature of psoriasis, and may be involved in the pathogenesis of the disease. We have previously shown that specialized dermal microvascular endothelial cells (DMEC) in psoriatic lesions promote the selective adherence of the CD4 CD45Ro helper T-cell subset. In this study, we examined the adhesive interaction between peripheral blood mononuclear cells and psoriatic DMEC in patients treated with ultraviolet B light (UVB), and correlated the results with the expression and function of endothelial adhesion molecules on DMEC. Seven psoriatic patients were exposed to one MED of UVB daily for 14 days, and the binding properties of their peripheral blood mononuclear cells (PBMC), and tissue specimens taken from their lesions on days 0, 2, 3, 6, 8, 11 and 14 of UVB treatment, were studied. The ability of psoriatic PBMC to adhere to non-irradiated control or UVB-treated psoriatic plaques was reduced by 70% after treatment with 2–3 MED, and complete inhibition was obtained after 8–11 MED. In contrast, exposure of psoriatic plaques to 2–3 MED had no effect on the capacity of DMEC to support normal PBMC binding, which was only reduced after 8–11 MED. In addition, psoriatic plaques which were shielded from direct UVB exposure also showed decreased PBMC binding, suggesting a systemic effect of UVB treatment. Immunoperoxidase staining revealed that CD54 (ICAM-1) and E-selectin were strongly expressed on dermal vessels in untreated psoriatic plaques. Treatment of patients with 6–8 MED significantly decreased CD54 and E-selectin, but was markedly induced following UVB treatment. In functional blocking studies, preincubation of tissue from untreated psoriatic plaques with anti-E-selectin antibody, but not antibodies against CD54 and VCAM-1, significantly inhibited the ability to bind normal PBMC. These observations suggest that UVB treatment interferes with the adhesive properties of both psoriatic PBMC and endothelial cells, and differentially regulates the expression of endothelial adhesion molecules. The study also provided direct evidence for the involvement of E-selectin in the adhesion of circulating lymphocytes to psoriatic endothelial cells.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 111 (1984), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Epidermis from explants of keratome slices of domestic pig skin can be induced to migrate, proliferate, and stratify if at least two serum protein factors and a source of nucleosides are present.The factor which is necessary for cell movement or spreading is destroyed by heating the serum to 100 C and is resistant to 80° C heating. This factor has a molecular weight of 65,000 and is identical to the ‘epibolin’ found by Stenn.Proliferation is dependent on a serum factor which is destroyed by heating to 80° C. However, cells which are denied this factor can make their own proliferation factors(s). Cell migration and cell proliferation usually occur together but they can be dissociated and are therefore independent phenomena.Increased cell proliferation can be achieved by some retinoids at the proper concentration but steroids, epidermal growth factor, a phorbol ester (TPA), and the use of injured skin as a keratome source failed to show in vitro hyperproliferation. Mitotic inhibition, however, can be induced by a variety of metabolic poisons (methotrexate, 5-fluorouracil, hydroxyurea), steroids, retinoids at high concentrations, and agents which increase adenosine 3′,5′-nionophosphate (cAMP).
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Optical and quantum electronics 27 (1995), S. 1081-1086 
    ISSN: 1572-817X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Optical and quantum electronics 14 (1982), S. 81-84 
    ISSN: 1572-817X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of insect behavior 9 (1996), S. 23-35 
    ISSN: 1572-8889
    Keywords: Reduviidae ; interspecific predation ; intraspecific predation ; nutrition ; kin recognition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Selected nutritional and developmental factors regulating the predatory behavior of first-instar spined assassin bugsSinea diadema (Fabricius) (Hemiptera: Reduviidae) were investigated. The longevity of unfed nymphs provided with free water, bean pod sections, or glucose solutions was not significantly greater than that of unfed nymphs which were not provided with a source of water. First-instarS. diadema that were provided with larvae ofEphestia kuehniella Zeller (Lepidoptera: Pyralidae) as prey began feeding 1.9 (±0.9) days after hatching. In contrast, first-instarS. diadema that were provided with conspecifics of the same age did not begin feeding until they were 3.9 (±0.9) days old. These results suggest that the potential nutritional benefits to be gained from feeding equal or outweigh the risk of attacking prey capable of effective self-defense only when nymphs have not fed for 4 days after hatching. Providing the nymphs with water or glucose solutions significantly delayed the onset of conspecific predation. Additional data are presented which demonstrate that first-instarS. diadema are not restrained from preying on siblings by kin recognition.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of insect behavior 9 (1996), S. 37-45 
    ISSN: 1572-8889
    Keywords: predator-prey interactions ; Reduviidae ; hunger ; cannibalism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Fed and unfed first instars of the spined assassin bugSinea diadema were paired to evaluate the effects of food deprivation on their behaviour during encounters. Fed nymphs encountering starved 5-day-old nymphs retreated from 69% of the encounters after contacting the starved nymph. In contrast, starved nymphs initiated grappling during 30% of the encounters with fed nymphs and retreated significantly less often than the fed nymphs. When a single fed nymph was placed together with two unfed 3-day-old nymphs in a closed arena, the fed nymphs generally were not the first nymph cannibalized and were the final survivors in 67% of 24 replicates. These results are discussed in the context of the relative costs and benefits of escalating or retreating from encounters.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 26 (1981), S. 179-183 
    ISSN: 1432-0649
    Keywords: 42.55 Mv ; 42.60 Da
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Subpicosecond pulse generation has been examined in synchronously pumped mode-locked ring dye laser systems. These include hybrid and composite absorber/gain media arrangements as well as a simple synchronous cavity. The shortest pulses recorded were 0.3 ps for the hybrid system, and this has been shown to be critically dependent on the positioning of the absorber jet in the centre of the cavity to better than 50 μm. Stable operation for subpicosecond pulse generation has been achieved in the ring configuration with greater wavelength tunability and higher average power conversion efficiency than with conventional cavity arrangements.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 29 (1982), S. 191-193 
    ISSN: 1432-0649
    Keywords: 42.55 Mv ; 42.60 Fe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using the saturable absorber 2-(p-Dimethylaminostyryl)-benzothiazolylethyl iodide, coumarin 6 has been passively mode-locked for the first time to give fully modulated trains of pulses of ∼4 ps duration and with peak powers of ∼3 MW tunable over the spectral range 526–547 nm.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0630
    Keywords: 33.50 ; 06.60 ; 82.50
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Exciting with picosecond pulses from a mode locked cw dye laser and using the Synchroscan continuously operating streak camera, the variation in the fluorescence lifetime with viscosity over the range 0.5 cp–250 cp of some mode locking and potential mode locking polymethine dyes of the cyanine family were investigated. The measured lifetimes were found to follow a ∼2/3 or 1/3 power dependence of the viscosity η.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0992-7689
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The geomagnetic response to the passage of a coronal mass ejection (CME) is studied. The passage of the CME resulted in a storm sudden commencement (SSC) at 2243 UT on March 20 1990 with disturbed magnetic activity during the following 24 h. The auroral, sub-auroral and equatorial magnetic response to the southward turning at 1314 (±5) UT on March 21 and the equatorial response to the southward turning associated with the SSC on 20 March are discussed in terms of existing models. It is found that the auroral and sub-auroral response to the southward turning associated with the SSC is a factor 2 or more quicker than normal due to the shock in the solar wind dynamic pressure. The low-latitude response time to the south-ward turning, characterised by Dst and the magneto-pause current corrected Dst*, is una.ected by the shock. Dst and Dst*, characteristic of the equatorial magnetic field, responded to the 1314 (±5) UT southward turning prior to the first observed substorm expansion phase onset, suggesting that a dayside loading process was responsible for the initial enhancement in the ring current rather than nightside particle injection. The response time of the auroral and sub-auroral magnetic field to the southward turning at 1314 (±5) UT on March 21 is measured at a variety of longitudes and latitudes. The azimuthal propagation velocity of the response to the southward turning varied considerably with latitude, ranging from #x0223C;8 km s−1 at 67°N to ∼4 kms−1 at 55°N. The southward velocity of the equatorward boundary of the northern polar convection pattern has been measured. This velocity was ∼1.2 km s−1 at 1600 MLT, although there was evidence that this may vary at different local times.
    Type of Medium: Electronic Resource
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