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  • Electronic Resource  (1,226)
  • 1995-1999  (1,064)
  • 1975-1979  (162)
  • Engineering  (515)
  • Magnetic resonance imaging  (420)
  • Rat  (292)
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  • Electronic Resource  (1,226)
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Year
Keywords
  • 11
    Electronic Resource
    Electronic Resource
    Haematology and clinical chemistry in rats: Comparison of different blood collection sites (1996)
    Springer
    Comparative clinical pathology 6 (1996), S. 160-166 
    Details
    ISSN: 1433-2981
    Keywords: Clinical chemistry ; Haematology ; Rat ; Sampling technique(s)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Blood samples from male and female rats were collected from four different sampling sites by the same technicians and analysed by the same procedures. The sampling sites were the abdominal aorta, orbital venous plexus, dorsal anastomotic orbital vein and sublingual vein. Values obtained in blood samples collected from peripheral sites were compared to those from the abdominal aorta, a sampling site which is normally unaffected by the sampling technique. There were significant differences in haematological parameters, particularly in leucocyte counts which were higher in samples collected from the peripheral sites than in those withdrawn from the central one. No significant changes were observed in coagulation parameters. A significant increase in clinical chemistry parameters related to soft tissue damage, namely creatinine kinase, lactate dehydrogenase, hydroxybutyrate dehydrogenase and aspartate aminotransferase, was seen in samples collected from both orbital sites. From this study it can be concluded that haematological and biochemical values obtained from rats in toxicological studies using different sampling sites are reliable both in males and females, provided that they are compared to values obtained from the same site in untreated controls. Sampling from the orbital plexus proved to be the least invasive method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00368460
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  • 12
    Electronic Resource
    Electronic Resource
    Giant purulent mesenteric cyst (1996)
    Springer
    Pediatric surgery international 11 (1996), S. 45-46 
    Details
    ISSN: 1437-9813
    Keywords: Purulent cystic lymphangioma ; Mesenteric cyst ; Intra-abdominal cystic lymphangioma ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Infected intra-abdominal cystic lymphangiomas are very rare. We report a case of a purulent mesenteric cyst, histologically a cystic lymphangioma, w which developed in a 1-year-old girl who presented with marked abdominal distension and high fever. Magnetic resonance imaging revealed that the huge cystic lesion occupied the entire peritoneal cavity. It originated from the mesocolon. It was removed completely, and contained sticky pus at the base where the right fallopian tube penetrated it, which indicated the focus of infection. This may be the first report of a purulent mesenteric cyst in which the route of infection was suspected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174584
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Repeated administration of a selective dopamine D2 receptor agonist to 6-OHDA — lesioned rats does not affect the survival and outgrowth of intrastriatal fetal mesencephalic grafts (1995)
    Springer
    Experimental brain research 107 (1995), S. 52-58 
    Details
    ISSN: 1432-1106
    Keywords: Transplantation ; Dopamine D2 receptor ; Image analysis ; Tyrosine hydroxylase immunocytochemistry ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of the present study was to investigate the effects of chronic activation of dopamine D2 receptors on the development of grafted fetal rat mesencephalic dopaminergic neurons. Therefore, unilaterally 6-hydroxydopamine — lesioned rats received intrastriatal mesencephalic cell suspension grafts and were subsequently chronically treated with the selective dopamine D2 receptor agonist LY 171555 (Quinpirole). After treatment for 6 consecutive weeks, the rats were processed for tyrosine-hydroxylase immunocytochemistry to assess the survival and outgrowth from grafted dopaminergic neurons. Morphological analysis revealed that, like the volume and morphology of the graft, neither the number nor the cell area of grafted dopaminergic neurons was significantly different between vehicle- and LY 171555-treated animals. To obtain a quantitative estimate of the graft-derived dopaminergic reinnervation, a computerized image analysis system was used. Using this procedure, which was based on the densitometric measurement of tyrosine hydroxylase immunoreactivity in the area adjacent to the grafted tissue, it was found that the extent of graft-derived outgrowth also appeared to be un-affected upon chronic treatment with LY 171555. It is concluded that long-term concurrent administration of a dopamine D2 receptor agonist for 6 consecutive weeks does not impair the survival and outgrowth of grafted rat fetal mesencephalic dopaminergic neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228016
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  • 14
    Electronic Resource
    Electronic Resource
    Leukoencephalopathy with swelling in children and adolescents: MRI patterns and differential diagnosis (1995)
    Springer
    Neuroradiology 37 (1995), S. 679-686 
    Details
    ISSN: 1432-1920
    Keywords: Leukoencephalopathy ; White matter swelling ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In children, several neurological disorders are characterised by spongiform leukoencephalopathy. MRI of the brain typically shows white matter swelling, but does not enable differentiation of the various underlying disorders. The aim of this article is optimisation of the diagnostic value of MRI in leukoencephalopathy accompanied by swelling. MRI-based inclusion criteria were met by 20 patients in our database. The images were analysed using a detailed scoring list. In 13 of the 20 patients the clinical diagnosis was known (11 definite and 2 probable diagnoses). Characteristic MRI abnormalities could be defined in these patients. Of the 7 patients without a diagnosis, 5 had identical MRI abnormalities: difuse hemisphere swelling and typical cysts in frontoparietal subcortical white matter and the tips of the temporal lobes. The clinical picture was also similar in these patients, suggesting a similar disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593394
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  • 15
    Electronic Resource
    Electronic Resource
    Leukoencephalopathy with swelling in children and adolescents: MRI patterns and differential diagnosis (1995)
    Springer
    Neuroradiology 37 (1995), S. 679-686 
    Details
    ISSN: 1432-1920
    Keywords: Key words Leukoencephalopathy ; White matter swelling ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In children, several neurological disorders are characterised by spongiform leukoencephalopathy. MRI of the brain typically shows white matter swelling, but does not enable differentiation of the various underlying disorders. The aim of this article is optimisation of the diagnostic value of MRI in leukoencephalopathy accompanied by swelling. MRI-based inclusion criteria were met by 20 patients in our database. The images were analysed using a detailed scoring list. In 13 of the 20 patients the clinical diagnosis was known (11 definite and 2 probable diagnoses). Characteristic MRI abnormalities could be defined in these patients. Of the 7 patients without a diagnosis, 5 had identical MRI abnormalities: diffuse hemisphere swelling and typical cysts in frontoparietal subcortical white matter and the tips of the temporal lobes. The clinical picture was also similar in these patients, suggesting a similar disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050179
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    Paper (German National Licenses)
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  • 16
    Electronic Resource
    Electronic Resource
    Assessment of T2- and T1-weighted MRI brain lesion load in patients with subcortical vascular encephalopathy (1998)
    Springer
    Neuroradiology 40 (1998), S. 503-506 
    Details
    ISSN: 1432-1920
    Keywords: Key words Vascular dementia ; Subcortical arteriosclerotic encephalopathy ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previous cross-sectional studies in patients with subcortical vascular encephalopathy (SVE) have shown little or no correlation between brain lesion load and clinical disability, which could be due to the low specificity of T2-weighted MRI. Recent studies have indicated that T1-weighted MRI may be more specific than T2-weighted MRI for severe tissue destruction. We studied 37 patients with a diagnosis of SVE and 11 normal controls with standardised T1- and T2-weighted MRI. All patients underwent detailed clinical assessment including a neuropsychological test battery and computerised gait analysis. Both the T2- and T1-weighted total MRI lesion loads different between patients and controls different, particularly T1. The ratio of T2-/T1-weighted lesion load was lower in controls than in patients. There was no overall correlation of T1- or T2-weighted lesion load with clinical disability, but group comparison of patients with severe and mild clinical deficits showed different lesion loads. We suggest that T1- and T2-weighted MRI lesion loads demonstrate relevant structural abnormality in patients with SVE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050633
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  • 17
    Electronic Resource
    Electronic Resource
    High signal in the adenohypophysis on T1-weighted images presumably due to manganese deposits in patients on long-term parenteral nutrition (1998)
    Springer
    Neuroradiology 40 (1998), S. 793-796 
    Details
    ISSN: 1432-1920
    Keywords: Key words Brain ; basal ganglia ; Pituitary gland ; Manganese ; Parenteral nutrition ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hypermanganesaemia is reported in patients on long-term parenteral nutrition. Deposition of manganese, giving high signal on T1-weighted images, may involve the basal ganglia. MRI in nine patients (mean age 51 years, range 31–75 years) on long-term parenteral nutrition (mean duration 30 months, range 6–126 months), demonstrated high signal in the anterior pituitary gland on T1-weighted sagittal and coronal images. The gland appeared normal on T2-weighted images. Signal intensity in the basal ganglia on T1-weighted images was increased in all patients. Endocrine assessment showed no significant abnormality. Neurological examination showed a mild parkinsonian movement disorder in one patient. Hypermanganaesemia was present in all nine (1.3–2.8 μmol/l, mean 1.87 μmol/l). The high signal in the anterior pituitary gland was probably related to deposition of paramagnetic substances, especially manganese.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050686
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    Paper (German National Licenses)
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  • 18
    Electronic Resource
    Electronic Resource
    MRI and MR angiography of vertebral artery dissection (1997)
    Springer
    Neuroradiology 39 (1997), S. 329-340 
    Details
    ISSN: 1432-1920
    Keywords: Key words Arteries ; vertebral ; Arteries ; dissection ; Magnetic resonance imaging ; Magnetic resonance angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A review of 4,500 angiograms yielded 11 patients with dissection of the vertebral arteries who had MRI and (in 4 patients) MR angiography (MRA) in the acute phase of stroke. One patient with incidental discovery at arteriography of asymptomatic vertebral artery dissection and two patients with acute strokes with MRI and MRA findings consistent with vertebral artery dissection were included. Dissection occurred after neck trauma or chiropractic manipulation in 4 patients and was spontaneous in 10. Dissection involved the extracranial vertebral artery in 9 patients, the extra-intracranial junction in 1, and the intracranial artery in 4. MRI demonstrated infarcts in the brain stem, cerebellum, thalamus or temporo-occipital regions in 7 patients with extra- or extra-intracranial dissections and a solitary lateral medullary infarct in 4 patients (3 with intracranial and 1 with extra-intracranial dissection). In 2 patients no brain abnormality related to vertebral artery dissection was found and in one MRI did not show subarachnoid haemorrhage revealed by CT. Intramural dissecting haematoma appeared as crescentic or rounded high signal on T1-weighted images in 10 patients examined 3–20 days after the onset of symptoms. The abnormal vessel stood out in the low signal cerebrospinal fluid in intracranial dissections, whereas it was more difficult to detect in extracranial dissections because of the intermediate-to-high signal of the normal perivascular structures and slow flow proximal and distal to the dissection. In two patients examined within 36 h of the onset, mural thickening was of intermediate signal intensity on T1-weighted images and high signal on spin-density and T2-weighted images. MRA showed abrupt stenosis in 2 patients and disappearance of flow signal at and distal to the dissection in 5. Follow-up arteriography, MRI or MRA showed findings consistent with occlusion of the dissected vessel in 6 of 8 patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050418
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  • 19
    Electronic Resource
    Electronic Resource
    MRI in detection of brain metastases at initial staging of small-cell lung cancer (1996)
    Springer
    Neuroradiology 38 (1996), S. 207-210 
    Details
    ISSN: 1432-1920
    Keywords: Small-cell lung cancer ; Brain metastasis ; Magnetic resonance imaging ; Staging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We prospectively investigated 40 patients with small-cell carcinoma of the lung (SCLC) for signs of brain metastasis by neurological examination and MRI of the brain, to determine the significance of MRI for staging. MRI could not be completed in one patient, who was excluded from the study. The MRI studies of the remaining patients showed no abnormalities in 12, cerebral infarcts in 2 and brain metastases in 11 patients, of whom 3 no relevant symptoms. Nonenhancing white matter lesions were found in 14 patients. In 3 of the 4 patients with an abnormal neurological examination at diagnosis, nonenhancing white matter lesions later developed into contrast enhancing lesions compatible with brain metastases; in 2, this occurred during the course of the chemotherapy. MRI did not change the clinical staging in patients with asymptomatic brain metastases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00596529
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  • 20
    Electronic Resource
    Electronic Resource
    MRI in detection of brain metastases at initial staging of small-cell lung cancer (1996)
    Springer
    Neuroradiology 38 (1996), S. 207-210 
    Details
    ISSN: 1432-1920
    Keywords: Key words Small-cell lung cancer ; Brain metastasis ; Magnetic resonance imaging ; Staging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We prospectively investigated 40 patients with small-cell carcinoma of the lung (SCLC) for signs of brain metastasis by neurological examination and MRI of the brain, to determine the significance of MRI for staging. MRI could not be completed in one patient, who was excluded from the study. The MRI studies of the remaining patients showed no abnormalities in 12, cerebral infarcts in 2 and brain metastases in 11 patients, of whom 3 no relevant symptoms. Nonenhancing white matter lesions were found in 14 patients. In 3 of the 4 patients with an abnormal neurological examination at diagnosis, nonenhancing white matter lesions later developed into contrast enhancing lesions compatible with brain metastases; in 2, this occurred during the course of the chemotherapy. MRI did not change the clinical staging in patients with asymptomatic brain metastases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00596529
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