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  • 1
    Electronic Resource
    Electronic Resource
    Der Zusammenhang zwischen Prognose und Kieler Klassifikation der malignen Non-Hodgkin-Lymphome (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 539-543 
    Details
    ISSN: 1432-1440
    Keywords: Non-Hodgkin lymphoma ; “Kiel” classification ; Prognosis of malignant lymphoma ; Non-Hodgkin-Lymphome ; Kieler Klassifikation ; Prognose der malignen Lymphome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Anhand der klinischen Verläufe von 201 Patienten mit malignen Non-Hodgkin-Lymphomen wird der Zusammenhang zwischen der Prognose und der histologischen Einteilung nach der Kieler Klassifikation dargestellt. Die Fünfjahres-Überlebensrate bei 133 Patienten mit Lymphomen niedrigeren Malignitätsgrades lag bei 63% und bei 68 Patienten mit Lymphomen höheren Malignitätsgrades bei 23%, wobei Strahlen- und Chemotherapie in unterschiedlicher Weise eingesetzt wurden. Die günstigste Prognose hatten die Patienten mit zentrozytisch-zentroblastischen Lymphom, unabhängig vom Ausbreitungsstadium, während die Patienten mit lymphoblastischem Lymphom die ungünstigste Prognose hatten. Diese Ergebnisse unterstreichen die Bedeutung einer über rein morphologische Kriterien hinausgehenden Klassifikation der malignen Non-Hodgkin-Lymphome.
    Notes: Summary The clinical course of 201 patients with malignant non-Hodgkin-lymphomas was analysed according to the Kiel classification. The five-year survival rate of 133 patients with lymphomas of low grade malignancy was 63% in comparison to 23% out of 68 patients with lymphomas of high grade malignancy. Radio- and chemotherapy were used in a different way. Patients with centrocytic-centroblastic lymphomas had the best prognosis, which was not influenced by the stage of the disease. The poorest prognosis was observed in patients with lymphoblastic lymphomas. These results support the importance of a classification of malignant non-Hodgkin-lymphomas which is not only based on morphological criteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477249
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  • 2
    Electronic Resource
    Electronic Resource
    Konservierung von hämopoetischen Stammzellen (1975)
    Springer
    Journal of cancer research and clinical oncology 83 (1975), S. 285-291 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das CFU-S-Potential von Mausknochenmark, das Transplantationspotential von autologem und allogenem Affenknochenmark sowie das CPU-C-Potential von menschlichem Knochenmark kann ohne Vitalitätsverlust eingefroren und wieder aufgetaut werden. Eine wichtige Voraussetzung für eine optimale Stammzellrecovery ist, daß die intrazellulären protektiven Substanzen Glycerin oder DMSO durch langsam stufenweise Verdünnung nach dem Auftauen entfernt werden, damit eine osmotische Schädigung der Zellen vermieden wird.
    Notes: Summary The CFU-S potential of mouse bone marrow, the transplantation capacity of autologous and allogeneic monkey bone marrow and the CPU-C potential of human bone marrow can be cryopreserved without loss of viability. It is critical for an optimal stem cell recovery to avoid an osmotic shock after thawing. The intracellular cryoprotectives glycerol and DMSO which provide a high osmotic pressure should be removed from the thawed cells by a slow stepwise dilution procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00573015
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  • 3
    Electronic Resource
    Electronic Resource
    Optimal therapy in medulloblastoma (1979)
    Springer
    Acta neurochirurgica 50 (1979), S. 117-125 
    Details
    ISSN: 0942-0940
    Keywords: Medulloblastoma ; Prognosis ; Radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-eight children with medulloblastoma (19 boys and 9 girls) were treated at the Departments of Neurosurgery and Radiotherapy in Essen between 1969 and 1977, and were followed prospectively after surgical treatment and postoperative irradiation. Because different radiation techniques had been used, these patients were divided into two groups, one given a limited irradiation volume and the other irradiation of the entire central nervous system. The results obtained in the former group were inferior to those in the latter. All living patients in the second group are in good condition. Special attention is paid to the technique of irradiation and the factors which may influence prognosis. Even after the relatively short follow up period of one to five years, it may be concluded that high-dose irradiation of the entire central nervous system considerably improved the prognosis of medulloblastoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01813556
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  • 4
    Electronic Resource
    Electronic Resource
    Conductivité électrique totale de sels doubles de type iodure d'argent—polydiiodure de N pentylène N′ alkylène tétraméthyl N, N, N′, N′, diammonium (1986)
    Springer
    Journal of applied electrochemistry 16 (1986), S. 505-512 
    Details
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Description / Table of Contents: Abstract Ionenes with the formula {[NMe2(CH2)5NMe2(CH2) n ]2I}p (where Me=methyl group;n=3, 4, 5; andp the degree of polymerization) have been prepared. Their NMR and IR spectra are shown and discussed. When these compounds are associated with silver iodide they give conducting compounds which obey the Arrhenius law. The highest conductivity of the AgI−N-pentylene, N′-alkylene, N, N, N′, N′-tetramethyl diammonium polyiodide system, at 25°C, is 0.01 Ω cm−1, corresponding to a compound containing 80% of AgI equivalent. This study has been carried out with the purpose of achieving solid generators.
    Notes: Résumé Les ionènes de formule {[NMe2(CH2)5NMe2(CH2) n ]2I}p (avec Me=radical méthyl;n=3, 4, 5; etp le degré de polymérization) ont été préparés. Leur spectre RMN et IR est présenté et discuté. Associés à de l'iodure d'argent, ils donnent des composés conducteurs qui suivent la loi d'Arrhénius. Le système AgI-polydiiodure de N pentylène N′ propyléne tétraméthyl N, N, N′, N′ diammonium possède à 25°C une conductivité maximale de 0.01 Ω cm−1 pour une composition renfermant 80% en équivalent de AgI. Cette étude se place dans une perspective de mise au point de générateurs tout solide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01006845
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  • 5
    Electronic Resource
    Electronic Resource
    Liver uptake of 99mTc-labeled diphosphonate (DPD) by metastatic lesions from large bowel carcinoma (1985)
    Springer
    European journal of nuclear medicine 10 (1985), S. 467-468 
    Details
    ISSN: 1619-7089
    Keywords: 99mTc-DPD uptake ; metastases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Accumulation of 99mTc-diphosphonate was observed in 2 of 12 patients with liver metastases who had primary adenocarcinoma of the large bowel. The area of excessive radionuclide concentration corresponded well to the location of the hepatic metastases. The literature on this subject is reviewed and a possible mechanism of radionuclide accumulation is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256594
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  • 6
    Electronic Resource
    Electronic Resource
    The effects of different fixatives for immunofluorescent and immunoperoxidase localization of Factor VIII-related antigen in canine carotid artery and vascular prostheses (1986)
    Springer
    Journal of molecular histology 18 (1986), S. 351-356 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The evaluation of vascular grafts seeded with autologous endothelial cells requires a reliable method of endothelial cell identification. Previous attempts to identify positively tissue Factor VIII-related antigen, found in relatively large amounts in vascular endothelial cells, proved to be inconsistent when immunoperoxidase and immunofluorescent staining techniques were tried. Because the Factor VIII antigen is very labile, this study was performed to determine an optimal fixation technique for demonstrating this antigen in frozen sections of endothelial tissue. Unfixed, acetone-fixed, and formalin-fixed sections of canine carotid artery as well as vascular grafts fixed in 1-ethyl-3-(3-diaminopropyl)-carbodiimide were examined by an indirect immunofluorescence technique. Also, the immunoperoxidase method of Factor VIII identification was applied to unfixed, acetone-fixed, and carbodiimide-fixed endothelial cell seeded vascular grafts. Acetone was the preferred fixative, resulting in excellent antigen preservation with minimal background staining. The immunoperoxidase technique of Factor VIII-related antigen identification was found to be the method of choice because of its sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01675215
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  • 7
    Electronic Resource
    Electronic Resource
    Immunocytochemical evidence for intragranular processing of pro-opiomelanocortin in the melanotropic cells of the rabbit (1985)
    Springer
    Cell & tissue research 242 (1985), S. 365-370 
    Details
    ISSN: 1432-0878
    Keywords: Melanotrophs ; Immunogold technique ; Secretory vesicles ; γ3-MSH ; α-MSH ; Endorphins ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The immunogold technique, employing antisera with clear-cut specificities, was used to localise different processing stages of pro-opiomelanocortin (POMC) in rabbit melanotropic cells. While the antiserum against γ 3-MSH labelled all the secretory granules including intrasaccular condensations in the Golgi apparatus, antisera against α-MSH only labelled extra-Golgi secretory vesicles (SV). All extra-Golgi SV were likewise labelled with the three antisera against α-MSH used, despite their different specificities for the desacetylated, N-acetylated or C-amidated forms of the peptide. The antibody against β-endorphin also labelled the extra-Golgi SV, while only some SV were labelled with the antibody against γ-endorphin. These results correlate with biochemical data in favour of mainly — if not exclusively — intragranular processing of POMC. Except for γ3-MSH, the cleavage of which could coincide with Golgi packaging of secretory material, other post-translational modifications of the precursor seem to occur when SV are discharged outside the Golgi area. The cleavage of γ-endorphin appears to be a later step in POMC processing, occurring in some mature SV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214549
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  • 8
    Electronic Resource
    Electronic Resource
    Untersuchungen zu Korrosionsproblemen bei der Förderung von Sauergas (1977)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 28 (1977), S. I 
    Details
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/maco.19770280125
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  • 9
    Electronic Resource
    Electronic Resource
    Untersuchungen zum Korrosionsmechanismus von unlegiertem Stahl in sauerstofffreien Kohlensäurelösungen - Teil II. Kinetik der Eisenauflösung (1978)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 29 (1978), S. 98-100 
    Details
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Investigations into the Corrosion Mechanism of Mild Steel in Oxygen-Free Carbon Dioxide Solutions. Part II. Kinetic of Iron DissolutionMeasuring the potential dependence of the anodic iron dissolution at mild steel in O2-free CO2-containing 0,5 M sodium sulfate solutions at temperatures between 25 and 75 °C an anodic Tafel-slope of ba = 40 ± 1 mV was found. This means that the active iron dissolution follows the uncatalyzed Bockris-mechanism. The corrosion rates at the free corrosion potential were measured in dependence of temperature and CO2 concentration by extrapolation of anodic Tafellines and by polarisation resistance measurements. From these results the activation energy of the iron dissolution was calculated to be 50 to 100 kJ/mol depending on pH. Based on all experimental results a complete corrosion mechanism is formulated.
    Notes: Durch Ermittlung der Potentialabhängigkeit der anodischen Eisenauflösungsgeschwindigkeit an unlegiertem Stahl in sauerstofffreien kohlendioxidhaltigen 0,5 M Natriumsulfatlösungen wurde bei Temperaturen von 25 bis 75°C eine Steigung der anodischen Tafelgeraden von ba = 40 ± 1 mV gemessen. Hieraus folgt, daß die aktive Eisenauflösung in diesem Temperaturbereich nach dem unkatalysierten Bockris-Mechanismus verläuft. Durch Extrapolation anodischer Tafelgeraden und durch Polarisationswiderstandsmessungen wurden die Korrosionsgeschwindigkeiten am Ruhepotential in Abhängigkeit von der Temperatur und der Kohlendioxidkonzentration ermittelt. Aus diesen Werten konnte die Aktivierungsenergie der Eisenauflösung berechnet werden. Sie liegt je nach pH-Wert der Lösung zwischen 50 und 100 kJ/mol. Auf Basis der bisherigen Untersuchungen wurde ein vollständiger Korrosionsmechanismus formuliert.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/maco.19780290204
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  • 10
    Electronic Resource
    Electronic Resource
    Zum Korrosionsverhalten von unlegierten und niedriglegierten Stählen in Kohlensäurelösungen (1978)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 29 (1978), S. 237-245 
    Details
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Corrosion of unalloyed and low alloyed steels in carbonic acid solutionsIn long period experiments unalloyed steels were found to corrode in O2-free CO2-saturated 0,5 M sodium sulfate solutions at 25° C with flow independent corrosion rates of 0,05-0,1 mm/a. Cold-work at unalloyed steels as well as higher contents of phosphorus, copper and chromium in unalloyed and low alloyed steels increased the corrosion rate to 0,2 to 1,4 mm/a. In O2-free CO2-saturated distilled water unalloyed steel showed a decreased resistance affording corrosion rates of 0,4 mm/a. Traces of oxygen as introduced by CO2 containing 100 ppm O2 increased the corrosion rate only above pH 4,2. All investigated unalloyed and low alloyed steels showed pitting corrosion after long induction periods. The shortest induction periods were observed in O2-free CO2-saturated distilled water. Sulfate ions and traces of oxygen seem to inhibit pitting corrosion.
    Notes: In Langzeitversuchen wurden für unlegierte Stähle in O2-freier, CO2-gesättigter 0,5 M Natriumsulfatlösung bei 25 °C strömungsunabhängige Abtragsraten von 0,05 bis 0,1 mm/a gemessen. Kaltverformung bei unlegiertem Stahl sowie höhere Gehalte an Phosphor, Kupfer und Chrom in un- und niedriglegierten Stählen steigerten die Korrosionsgeschwindigkeit auf 0,2 bis 1,4 mm/a. In O2-freiem, CO2-gesättigtem destilliertem Wasser wies unlegierter Stahl mit Korrosionsraten von 0,4 mm/a eine geringere Beständigkeit auf. Sauerstoffspuren, wie sie durch 100 ppm O2 enthaltendes CO2 eingetragen wurden, beschleunigten die Korrosion erst oberhalb pH 4,2. Alle untersuchten un- und niedriglegierten Stähle zeigten nach längeren Induktionszeiten z. Tl. erhebliche Lochkorrosion. Die kürzesten Induktionszeiten wurden in O2-freiem, CO2-gesättigtem destilliertem Wasser beobachtet. Sulfationen und Sauerstoffspuren scheinen die Lochkorrosion zu verzögern.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/maco.19780290402
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