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  • 1
    Electronic Resource
    Electronic Resource
    Gliofibroma: immunohistochemical analysis (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 207-210 
    Details
    ISSN: 1432-0533
    Keywords: Gliofibroma ; Immunohistochemistry ; Astrocytes ; Desmoplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of gliofibroma occurring in an adult patient as a large circumscribed supratentorial tumor is reported. The bimorphic pattern was substantiated and further analyzed by immunohistochemistry. Some evidence in favor of collagen production by mesenchymal and/or inflammatory cells leading to a progressive fibrous replacement of the glial cells in this particular tumor type is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308481
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interstitial Irradiation for Craniopharyngioma (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 389-395 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Brain tumour; brachytherapy; craniopharyngioma; interstitial irradiation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ The results of interstitial irradiation treatment for craniopharyngioma in two patients with six year follow-ups are presented. Stereotactic interstitial irradiation with Iodine-125 sources as sole therapy was employed in two adult patients who refused surgical resection. The diagnoses were confirmed by stereotactic biopsy. The first tumour which underwent interstitial irradiation was solid and 4 cm in diameter, and the second, 2.7 cm in diameter, had both cystic and solid components. The implanted Iodine-125 seeds delivered 67 Gy and 60 Gy to tumour periphery at the rate of 12 and 14 cGy/h, respectively, were removed at the end of designated radiation periods. Tumour shrinkage and central hypodensity, first observed 3 months after irradiation, continued until one tumour shrank to less than 1 cm at 12 months, and the other disappeared completely at 24 months. In both cases functional integrity was restored, and neither radiation induced toxicity nor recurrence has occurred six years after treatment. The results in these two cases suggest that solid craniopharyngiomas are sensitive to interstitial irradiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050447
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Optimal therapy in medulloblastoma (1979)
    Springer
    Acta neurochirurgica 50 (1979), S. 117-125 
    Details
    ISSN: 0942-0940
    Keywords: Medulloblastoma ; Prognosis ; Radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-eight children with medulloblastoma (19 boys and 9 girls) were treated at the Departments of Neurosurgery and Radiotherapy in Essen between 1969 and 1977, and were followed prospectively after surgical treatment and postoperative irradiation. Because different radiation techniques had been used, these patients were divided into two groups, one given a limited irradiation volume and the other irradiation of the entire central nervous system. The results obtained in the former group were inferior to those in the latter. All living patients in the second group are in good condition. Special attention is paid to the technique of irradiation and the factors which may influence prognosis. Even after the relatively short follow up period of one to five years, it may be concluded that high-dose irradiation of the entire central nervous system considerably improved the prognosis of medulloblastoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01813556
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Micro-invasive squamous cell carcinoma arising in a pre-existing intraventricular epidermoid cyst (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1008-1012 
    Details
    ISSN: 0942-0940
    Keywords: Squamous cell carcinoma ; brain neoplasm ; epidermoid cyst ; malignant transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors report the case of a 67-year-old woman with primary micro-invasive squamous cell carcinoma located in the lateral ventricle and originating from an epidermoid cyst. Radiological and histological features of the neoplasm are described and the relevant literature is studied briefly. Two consecutive surgical specimens were studied by light microscopy. In the histological sections of the subtotally removed material of the first operation, the cyst wall was layered by epithelium — the same as expected in an epidermoid cyst — and showed foci with mild to moderate dysplastic changes. Theses changes did not reach up to the degree of a carcinoma. However, because the cyst could not be resected totally, the possibility of a squamous cell carcinoma was considered in the differential diagnosis. In the present case, the diagnosis was firmly established in a second surgical specimen obtained ten months after the first operation. Now, the tumour proved to be a primary squamous cell carcinoma, which exhibited severe dysplastic changes. Primary squamous cell carcinoma of brain is extremely rare. To our knowledge, only 20 such tumours with pre-existing epidermoid cyst have been reported in the central nervous system. The intriguing observation in this case is a three year recurrence free survival following the subtotal removal of the malignant neoplasm at the second surgery, without postoperative radiotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411292
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    Paper (German National Licenses)
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