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  • Electronic Resource  (62)
  • 1985-1989  (50)
  • 1970-1974  (11)
  • 1955-1959  (1)
  • 21
    Electronic Resource
    Electronic Resource
    Juvenile colloid milium (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 16 (1989), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 7-year-old Italian girl with juvenile colloid milium was studied with histological, immunohistochemical, and electron microscopic methods. This patient had a well-documented history of severe sunburn and developed the lesions on the face shortly afterward. Numerous apoptotic keratinocytes were observed in the lower epidermis. These cells began their degeneration with filamentous whorl formation (or filamentous degeneration) of tonofilaments. In the papillary dermis the colloid substance was resolved by the electron microscopy into either wavy, thin filaments derived from the epidermal keratinocytes or typical amyloid filaments. Many desmosomes and gap junctions were found in the colloid substance. Polyclonal antikeratin antibody (DAKO) was positive in the colloid substance, particularly in the parts close to the epidermis. These findings suggested that juvenile colloid milium is different from adult colloid milium despite clinical similarities and that the former belongs to the group of actinic amyloid K, i.e. amyloidoses due to actinic degeneration of keratinocyte and its keratin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1989.tb00033.x
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  • 22
    Electronic Resource
    Electronic Resource
    Electron microscopic studies of Moll's gland cyst (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 14 (1987), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Several Moll's gland cysts from 4 different patients were studied with the light and electron microscopes. The cysts were lined with a combination of several different epithelia, such as completely keralinized epithelium, glycogen-rich, stratified squamous epithelium with incompletely keratinized luminal cells, sweat duct epithelium, and secretory cells. In one case in addition to the above components, secretory-type wall cells contained very large lamellar inclusions which were PAS positive and diastase resistant. It was concluded that Moll's gland cyst is composed of dilated duct of the Moll's gland and secretory segment; the proportion of each segment is variable but the portion showing ductal differentiation is usually predominant and typical secretory epithelium is not always seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1987.tb00123.x
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  • 23
    Electronic Resource
    Electronic Resource
    Variation of the distribution pattern of SH groups and SS linkages in the human epidermis (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 13 (1986), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Normal epidermis of various sites of human body was examined by N-(7-dimethyl-amino-4-methyl-3-coumarinyl)maleimidc (DACM) method for SH groups and SS linkages. The horny cells in the palm and sole showed a gradual occurrence of a SH membranous pattern, while those in other sites revealed an abrupt formation of the SH membranous pattern just above the granular layer. In the palm and sole epidermis the number of layers which exhibit membranous pattern of SH-positivity was thicker than that in the other epidermis; the low- through mid-layers of horny cells in the former sites seemed to contain not only SS-positive but also SH-positive substance at cell peripheries. The DACM staining for SS linkages showed the presence of a granular fluorescence in the cytoplasm of the granular cells of the epidermis in the human palm and sole, but not in other sites. The granular cells in human lip displayed a granular fluorescence in the cytoplasm by cither SH or SS DACM staining. All the SH- or SS-positive granular fluorescence was related to keratohyaline granules. These findings indicate that there may be some variations of the distribution pattern of the epidermal cellular proteins with SH and/or SS and a difference in chemical composition of keratohyaline granules between different anatomical sites of human body.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1986.tb01524.x
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  • 24
    Electronic Resource
    Electronic Resource
    Occurrence of tetrodotoxin in the starfishes Astropecten polyacanthus and A. scoparius in the Seto Inland Sea (1985)
    Springer
    Marine biology 90 (1985), S. 61-64 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Two starfishes, “togemomijigai” Astropecten polyacanthus and “momijigai” A. scoparius were collected from the Seto Inland Sea in October 1983 through November 1984, and assayed for toxicity by the standard method for tetrodotoxin (TTX). Most of the 54 A. polyacanthus specimens assayed were toxic, with the highest toxicity score being 520 mouse units (MU) g-1. All seven A. scoparius were toxic, with the highest score being 46 MU g-1. The toxin from A. polyacanthus was purified by a method which consisted mainly of activated charcoal treatment, and chromatography on CM-Sephadex C-25 and Bio-Rex 70 columns. The purified starfish toxin showed a specific toxicity of 4 700 MU mg-1, a value which was almost comparable to that of authentic TTX. From the thin-layer chromatographic and electrophoretic behavior, along with 1H-NMR spectrum, A. polyacanthus toxin was identified as TTX.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428215
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  • 25
    Electronic Resource
    Electronic Resource
    Distribution of tetrodotoxin in various organs of the starfish Astropecten polyacanthus (1987)
    Springer
    Marine biology 96 (1987), S. 385-390 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Tissues of various organs of the starfish Astropecten polyacanthus collected in the Hiroshima Prefecture from April 1985 to June 1986 were analyzed for lethal potency by the assay method for tetrodotoxin. The ovary showed the highest potency (47 to 1 450 MU g-1), followed by the digestive organs (〈10 to 960 MU g-1) and the exoskeleton including spines and tube-feet (〈10 to 170 MU g-1). The pyloric caecum and testis were less toxic. Overall toxicity was remarkably higher in females (2 060±382 MU, mean±SE) than in males (1 106±214 MU).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412522
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  • 26
    Electronic Resource
    Electronic Resource
    Paralytic shellfish poison in the “hiogi” scallop Chlamys nobilis (1988)
    Springer
    Marine biology 98 (1988), S. 243-246 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Attempts were made to analyze the toxin composition of the toxic “hiogi” scallop Chlamys nobilis. The toxins were partially purified from the digestive glands by column chromatography using Bio-Gel P-2 and Bio-Rex 70 (H+ form), resulting in separation into protogonyautoxin (PX), gonyautoxin (GTX) and saxitoxin (STX) fractions. Their total potencies were scored to be 〈100 mouse units (MU), 3200 MU and 3700 MU, respectively. A 5-min hydrolysis with 0.1 N HCl enhanced the potencies of PX and GTX fractions to 450 MU and 12000 MU respectively, whereas no enhancement occurred in the STX fraction at all. Electrophoretic, thin-layer chromatographic and high performance liquid chromatographic analyses demonstrated that the PX fraction consisted mainly of GTX8 and its epimer, the GTX fraction of GTX5, GTX6, along with two unidentified toxins, and the STX fraction exclusively of two unidentified toxins. This rather unique composition suggested a complex metabolism of PSP in this species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391201
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  • 27
    Electronic Resource
    Electronic Resource
    Vibrio alginolyticus, a tetrodotoxin-producing bacterium, in the intestines of the fish Fugu vermicularis vermicularis (1987)
    Springer
    Marine biology 94 (1987), S. 625-630 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract To clarify the mechanism of toxification in animals contaminated with tetrodotoxin, the intestinal contents of the puffer Fugu vermicularis vermicularis were examined for bacterial flora in 1985. Twenty-six out of 33 strains belonged to the genus Vibrio. These bacteria were classified into Groups I to VII, based on biological and biochemical characters. High performance liquid chromatography and gas chromatography-mass spectrometry, together with mouse bioassay for toxicity, clearly demonstrated that Group I produced tetrodotoxin and anhydrotetrodotoxin under cultivation with a medium composed of Phytone peptone (BBL) and NaCl. Some other groups also produced this toxin and/or related substances to some extent. Strains of Group I were all identified as Vibrio alginolyticus. Two strains among four produced a detectable amount of tetrodotoxin and/or anhydrotetrodotoxin, as measured by all instrumental analyses applied. Our findings suggest that some strains of V. alginolyticus are closely related to the toxification of the puffer, and probably of other species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431409
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  • 28
    Electronic Resource
    Electronic Resource
    Two patients with meningioma visualized as high uptake by SPECT with N-isopropyl-p-iodo-amphetamine (I-123) (1988)
    Springer
    Neuroradiology 30 (1988), S. 351-354 
    Details
    ISSN: 1432-1920
    Keywords: N-isopropyl-p-iodo-anphetamine (123I-IMP) ; Single photon emission computed tomography ; meningioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It has been reported that brain tumors show decreased IMP uptake, however, we encountered two cases of meningioma which had initially increased IMP uptake. SPECT was performed at 30 min, 2 hr and 6 hr after intravenous administration of IMP (3 mCi). The delayed images (2 and 6 h) showed decreased IMP uptake. These were convexity and parasagittal meningiomas which had tumor stains at angiography. Although the mechanism of IMP uptake in brain tumor is still unclear, this finding should be considered in the interpretation of IMP-SPECT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00328188
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  • 29
    Electronic Resource
    Electronic Resource
    Tetrodotoxin-producing bacteria from the blue-ringed octopus Octopus maculosus (1989)
    Springer
    Marine biology 100 (1989), S. 327-332 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Several live specimens of the blue-ringed octopus Octopus maculosus were collected from the Philippines in November 1985, and from Japan in February 1986, and the distribution of toxicity, along with toxin composition, in the posterior salivary gland and other soft parts were examined. Tetrodotoxin (TTX: 1400 mouse units g-1) was detected in the posterior salivary gland of a Japanese specimen, while not only the salivary gland but other soft parts were toxic in the Philippine specimens. The Philippine specimens contained TTX and anhydrotetrodotoxin, the Japanese specimen TTX, 4-epitetrodotoxin, and an unknown toxin. The posterior salivary gland, intestine and other parts were excised from the Philippine specimens and examined for bacterial flora. Twenty-two dominant strains were isolated and cultured in a 2xORI medium (Ocean Research Institute, Simidu and Tsukamoto 1985) at 20°C for 20 to 48 h. Cells were harvested by centrifugation, and disrupted by ultrasonication. The toxins were partially purified from the cell lyzate by ultrafiltration and Bio-Gel P-2 column-chromatography. Instrumental analyses disclosed that 16 of the 22 strains produced TTX and/or related substances. Six strains which clearly exhibited TTX productivity were identified as Alteromonas (2 strains), Bacillus (2), Pseudomonas (1) and Vibrio (1), based on biochemical and biological characteristics. Of these, one strain each of Bacillus and Pseudomonas produced TTX at a level detectable by the mouse assay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391147
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  • 30
    Electronic Resource
    Electronic Resource
    Changes in microflora of a puffer fish Fugu niphobles, with different water temperatures (1989)
    Springer
    Marine biology 101 (1989), S. 299-304 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Grass puffer Fugu niphobles, captured in November 1986 at Shimoda, Japan, and then reared at different temperatures ranging from 10 to 29°C, was examined for microflora changes in the skin, gill and intestines. At 10°C, the skin and gill were colonized mainly by Pseudomonas, Flavobacterium and Moraxella, while at 29°C Vibrio and Flavobacterium appeared abundantly. The intestinal microflora, consisting of Vibrio, Pseudomonas and Flavobacterium, revealed little temperature dependence, although the intrageneric composition of Vibrio changed conspicuously depending on the change of water temperature. Vibrio group 1, tentatively identified as V. alginolyticus, was detected in all tissues examined at 20 and 29°C. This, along with the fact that V. alginolyticus produces tetrodotoxin, suggests that the tetrodotoxin contained in puffer is, at least partly, accounted for by this bacterial species inhabiting intestines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428125
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