ISSN:
0942-0940
Keywords:
Adenosine
;
ATP
;
regional cerebral blood flow
;
RG-C6 glioma
;
intracarotid administration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We studied the effect of intravenous and intracarotid infusion of adenosine and adenosine triphosphate (ATP) on the regional blood flow of intracerebrally transplanted RG-C 6 tumours in rats, using the hydrogen clearance method. The intracarotid administration of adenosine or ATP selectively increased blood flow in the tumour, but did not produce any significant change either in the regional cerebral blood flow of the extratumoural ipsilateral hemisphere or in the ipsilateral hemisphere without tumour. The intracarotid administration of ATP at a dose of 10 Μg/kg/min produced the most effective increase in the tumour blood flow (+51.5± 16.8%). In contrast, both the intravenous administration of adenosine and that of ATP failed to increase tumour blood flow. These results may possibly indicate that intracarotid administration of the adenosine or ATP might contribute in selectively enhancing the delivery of anti-cancer agents to malignant brain tumours.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01410072
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