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  • Electronic Resource  (6)
  • 1975-1979  (5)
  • 1960-1964  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Möglichkeiten der Präzisionsgitterkonstantenmessung mit hochmonochromatischer Röntgen-Strahlung (1960)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 13 (1960), S. 830-832 
    Details
    ISSN: 0001-5520
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0365110X60002016
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  • 2
    Electronic Resource
    Electronic Resource
    Induction of histamine methyltransferase during experimental hydronephrosis: A mechanism of adaptation for histamine homeostasis in rabbit kidney (1975)
    Springer
    Inflammation research 5 (1975), S. 442-443 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion The strong raise in histamine content during the first day of experimental hydronephrosis seemed to induce a slow increase of histamine methyltransferase activity, the only histamine metabolizing enzyme in rabbit kidney [4]. This process of adaptation can be interpreted as a defence mechanism against the formation and the release of high amounts of histamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972663
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  • 3
    Electronic Resource
    Electronic Resource
    Histamine and peptic ulcer disease: Histamine methyltransferase activity in gastric mucosa of control subjects and duodenal ulcer patients before and after surgical treatment (1977)
    Springer
    Inflammation research 7 (1977), S. 75-79 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Histamine methyltransferase (HMT) activity was determined by a modified isotope assay in biopsy specimens from gastric mucosa of control subjects, duodenal ulcer patients and after various gastric operations. Enzymic activity of male control subjects who were ‘healthy’ with respect to their upper gastrointestinal tract was 70.4±12.8 pmol/(min×mg protein). In male duodenal ulcer patients HMT-activity was significantly lowered by 15%; following selective vagotomy with pyloroplasty a significant increase of 14% was observed as compared to controls. The difference between values before (59.9±13.3) and after (80.4±11.7) this operation was highly significant (p〈0.001). Experiments in a small number of patients showed that after other modifications of vagotomy elevated HMT-activities were also found, whereas after resection procedures such changes of enzymic activity did not occur. According to these results the low gastric HMT-activity of duodenal ulcer patients could play a role in the pathogenesis of a chronic peptic ulcer by being responsible for reduced histamine inactivation and — as a consequence —enhanced acid secretion. Furthermore, vagotomy seemed to influence acid secretion in human subjects not only by direct effects on the parietal cells, but also by an activation of histamine catabolism. One patient, who despite complete vagotomy showed both no reduction in acid secretion and a low gastric HMT-activity, may be the representative of a new population of peptic ulcer patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964884
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  • 4
    Electronic Resource
    Electronic Resource
    Structural requirements of imidazole compounds to be inhibitors or activators of histamine methyltransferase: Investigation of histamine analogues and H2-receptor antagonists (1978)
    Springer
    Inflammation research 8 (1978), S. 359-365 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of imidazole compounds (histamine analogues and H2-receptor antagonists) and of the specific histamine H2-receptor agonist dimaprit on histamine methyltransferase (HMT) from pig gastric mucosa was investigated. By their effect on HMT two groups of substituted imidazole compounds could be differentiated. Some were pure inhibitors of the enzyme, whereas others were inhibitors only in high concentrations (〉10−3 M) and activators of the enzyme in low concentrations. The strongest inhibitor of all the histamine analogues tested was 2-methylhistamine (I.D.50=0.6×10−4 M), whereas the strongest activation was exerted by 4-[(2-amino-ethylmercapto)-methyl]-5-methylimidazole (57% increase of enzymic activity at 10−4 M concentration). From the group of histamine H2-receptor antagonists only burimamide was an inhibitor (I.D.50=1.6×10−4 M) whereas metiamide and cimetidine belonged to the strongest activators of the enzyme (179% enzymic activity at 10−4 M concentration of metiamide). The strongest activator of all the substances tested in this series of compounds, however, was the non-imidazole compound dimaprit, which increased enzymic activity by 86% in as small a concentration as 10−5 M. For substituted imidazole ring systems an attempt is made to evaluate the structural requirements of the single compound to classify it as a pure inhibitor or a concentration-dependent inhibitor/activator of HMT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968615
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  • 5
    Electronic Resource
    Electronic Resource
    Die Orthologie der endokrinen Zellen im distalen ösophagus (1978)
    Springer
    Virchows Archiv 377 (1978), S. 311-328 
    Details
    ISSN: 1432-2307
    Keywords: Lower esophageal sphincter (LES) ; APUD-cells ; Orthology ; electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 327 ösophagus-Kardia-PrÄparaten aus dem Obduktionsgut war das Plattenepithel des distalen ösophagus einoder mehrfach von Kardiadrüsenepithel unterbrochen, in 60% fanden sich in den distalen drei Zentimetern innerhalb der Lamina propria gro\flÄchige Kardiadrüsen. Hier waren immer argyrophile Zellen in nennenswerter Anzahl. Bei gleichzeitig durchgeführten elektronenmikroskopischen Untersuchungen von BiopsieprÄparaten dieser Region lag die Trefferquote bei 65%. Die elektronenmikroskopische Differenzierung anhand der Granulastrukturen brachte sieben definierte Zellarten (EC, ECL, D, D1, AL, I bzw. M, S) sowie zwei von uns nicht klassifizierbare Typen zutage. Die RegelmÄ\igkeit, mit der wir diese Zellen sowohl bei Erwachsenen als auch Neugeborenen und Kleinkindern gefunden haben, lÄ\t uns im Vergleich mit den biochemischen und physiologischen Ergebnissen zu diesem Themenkreis vermuten, da\ diese endokrinen Zellen am „Schauplatz des Geschehens” als Paraneurone bzw. peptiderge Neurotransmitter die Funktion des unteren ösophagussphinkter (zumindest mit-)regulieren.
    Notes: Summary At the esophago-cardiac junction squamous epithelium is intermingled with gastric epithelium. Within the lamina propria of the distal 3 cm of the esophagus we found cardiac glands with many argyrophil cells in 60% of cases. Electron microscopy revealed seven well known types and two further forms which we could not identify: EC, ECL, D, D1; AL, I eg. M, S. It is supposed that these cells are modified neurotransmitters with a local activity. Their function is local regulation of the lower esophageal sphincter (LES).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00507132
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  • 6
    Electronic Resource
    Electronic Resource
    79. Planung und Datenanalyse bei prospektiven kontrollierten klinischen Studien (1978)
    Springer
    Langenbeck's archives of surgery 347 (1978), S. 457-465 
    Details
    ISSN: 1435-2451
    Keywords: Clinical trials, planning ; Clinical trials, data analysis ; Surgery, experimental ; Klinische Studien ; Planung ; Datenanalyse ; Experimentelle Chirurgie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei der Planung prospektiver kontrollierter Studien in der Chirurgie müssen Test- und Vergleichsgruppen gebildet, die Versuche genügend oft wiederholt, Patienten streng zufällig durch Randomisierung (Beispiel) zugeteilt und die Untersuchungen balanciert werden. Die deskriptive Datenanalyse soll schrittweise (Urliste, Rangliste, Spannweite, Medianwert, Quartilwerte, Histogramm, Mittelwert und Standardabweichung) durchgeführt werden Beispiel). Auf die Vorteile des Median-Quartil-Systems und auf die Voraussetzungen für die Anwendung verschiedener Signifikanzteste wird hingewiesen. Eine Beraterfunktion des experimentellen Chirurgen wird gefordert.
    Notes: Summary Planning of prospective controlled clinical trials in surgery requires the use of test and control groups, sufficiently frequent repetition of experiments, random allocation of patients to the groups (example), and balancing. The descriptive data analysis should be performed in a stepwise manner (list of raw data, rank list, range, median, quartiles, histogram, mean value, standard deviation). The advantages of the median-quartile-system and the prerequisites for application of various significance tests are pointed out. In the conduct of controlled clinical trials, the consultative role of experimental surgeons is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01579376
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