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  • Electronic Resource  (2)
  • Absorption  (1)
  • Carcinoma colorectal  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Absorption of β-methyl-digoxin determined after a single dose and under steady state conditions (1976)
    Springer
    European journal of clinical pharmacology 9 (1976), S. 307-314 
    Details
    ISSN: 1432-1041
    Keywords: Absorption ; man ; β-methyl-digoxin ; serum concentration ; urinary excretion ; radio-immunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Single doses of β-methyl-digoxin 0.4 mg were given to groups of 17 – 18 healthy volunteers as an intravenous infusion lasting 2 hours, or orally as Lanitop Liquidum® or Lanitop® tablets. The serum glycoside concentration and urinary glycoside excretion were measured over 8 and 32 h. The absolute bioavailability from the oral preparations in comparison with the infusion was lower for the first 8 h than for the entire 32 h of the investigation; the relative bioavailability from tablets was the same as from the solution for both periods. For both periods the area under the serum concentration/time curve and the urinary glycoside excretion were significantly lower after administration of the tablets than after intravenous infusion. Taking the average of both parameters, the absolute bioavailability of β-methyl-digoxin was about 80% from the solution and about 70% from the tablets. In 18 patients undergoing intravenous or oral therapy with β-methyl-digoxin steady state glycoside concentrations were compared in a cross-over study of intravenous maintenance therapy with Lanitop® ampoules or oral treatment with Lanitop® tablets. For a standard daily dose of 0.2 mg β-methyl-digoxin the serum concentrations were 1.35±0.10 ng/ml during both intravenous and oral administration. The intra-individual variation in glycoside concentration after changing from intravenous to oral maintenance therapy, or vice versa, was about the same as during continued intravenous or oral administration. It is concluded that the rate of rise of serum concentration after a single dose may be a useful indicator of the rate of absorption, but that the area under the serum concentration/time curve and the urinary glycoside excretion up to 32 h are unsuitable for determining equivalent doses of different formulations or routes of administration of digitalis glycosides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561665
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    173. Diagnostische Effizienz der rectal-digitalen Untersuchung : Ergebnis einer prospektiven Studie bei 2000 Patienten (1978)
    Springer
    Langenbeck's archives of surgery 347 (1978), S. 662-663 
    Details
    ISSN: 1435-2451
    Keywords: Carcinoma colorectal ; Polyps colorectal ; Rectal digital examination, diagnostic efficacy of ; Dickdarmcarcinom ; Dickdarmpolyp ; Vergleich: rectal digitale-endoskopische Untersuchung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer prospektiven Studie wurden 2000 Patienten von zwei Ärzten rectal-digital untersucht, und anschließend rektoskopiert. Es fanden sich 312 Tumore (127 Carcinome), 463 sonstige pathologische Befunde, 1225 Untersuchungen waren o.B. 75 von 312 Tumoren (24,0%) wurden von mindestens einem, 44 (14,1%) von beiden richtig getastet. Von den Tumoren, die auf den ersten 10 cm ab ano lagen, wurden nur 44% getastet, 56% der in dieser Region gelegenen und in zahlreichen Retrospektivstudien als palpabel bezeichnete Tumore konnten nicht getastet werden.
    Notes: Summary Of utmost importance is the fact that, of the tumors located in the first 10 cm ab ano, only 44% were palpable and 56% were not palpable. In a prospective study 2000 patients were examined by two medical doctors rectal-digitally and by rectoscopy. The findings included 312 tumors (127 carcinomas) and 463 other pathologic conditions. 1225 examinations were without pathologic findings. Seventy-five of 312 tumors (24.0%) were palpable for one of the examiners; 44 (14,1%) were palpated by both examiners. Therefore rectal digital examination is not apt to uncover midrectal tumors; rectoscopy should be performed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01579466
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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