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  • Digitale Medien  (4)
  • Multiple sclerosis  (2)
  • Remyelination  (2)
  • Acute toxicity  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Journal of neurology 208 (1974), S. 17-25 
    ISSN: 1432-1459
    Schlagwort(e): Multiple sclerosis ; Retrobulbar neuritis ; Optic nerve
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung 34 von 69 japanischen Patienten mit wahrscheinlicher multipler Sklerose (MS) zeigten Sehstörungen beim ersten Krankheitsschub. Bei 16 dieser 34 Patienten waren die Opticus-Symptome das einzige Symptom. Diese Fälle wurden als retrobulbäre Neuritis (RBN) diagnostiziert. Die klinischen Bilder dieser 16 Patienten wurden geschildert und analysiert. In dieser Serie überwogen weibliche Patienten im Verhältnis 4,3:1. Das Durchschnittsalter betrug bei Krankheitsbeginn 27 Jahre. Das Intervall zwischen dem Ende der ersten RBN zum nächsten Schub reichte von 1 Monat bis zu 13 Jahren. Seite und Art der Erkrankung, Schwere und Dauer der ersten Sehstörungen oder Grad der Besserung scheinen die folgende Entwicklung der anderen klinischen Symptome von MS nicht zu beeinflussen. Es ist bemerkenswert, daß 11 dieser 16 Patienten eine Sehstörung auch während des zweiten Schubes zeigten. Ein Vergleich der MS-Patienten, die eine Sehstörung als einziges Initialsymptom aufweisen, zwischen den östlichen und westlichen Ländern wäre in Zukunft wünschenswert.
    Notizen: Summary Of 69 consecutive Japanese patients with probable multiple sclerosis (MS), 34 patients showed visual impairment at the initial bout. 16 out of these 34 patients manifested only the optic symptoms at the onset, without other clinical evidence of MS, and the condition was diagnosed as retrobulbar neuritis (RBN) initially. The clinical pictures of these 16 patients are described and analyzed. This series showed a female preference with the male-to-female ratio of 1 to 4.3. The age at onset was 27 years on the average, which is not significantly different from that of the whole MS series (31 years). The interval from the end of the initial RBN to the second bout ranged from 1 month to 13 years, but was less than 4 years in all cases but 2. The laterality, mode of onset, severity and duration of the initial visual impairment, or the degree of recovery from the initial bout did not seem to influence the subsequent occurrence of other clinical evidences of MS. It is noteworthy that in 11 out of the 16 patients the symptom at the second bout was, or at least also included, visual impairment. Comparison of MS patients, who started with visual impairment as the sole initial symptom, between the Oriental and Western countries is warranted.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 45 (1979), S. 43-45 
    ISSN: 1432-0533
    Schlagwort(e): Cerebrotendinous xanthomatosis ; Segmental demyelination ; Remyelination ; Sural nerve ; Onion bubl
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In a case of cerebrotendinous xanthomatosis (CTX), confirmed biochemically and histologically, quantitative histological studies of the biopsied sural nerve revealed significantly higher incidence of de- and remyelination and onion bulb than in controls. The density of total myelinated fibers fell within the range of controls, although the density of large myelinated fibers seemed to be slightly decreased. It was suggested that the preferential involvement of the myelin sheath and Schwann cell may exist in CTX.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1432-0533
    Schlagwort(e): Multiple sclerosis ; Schwann cell ; Remyelination ; Glial fibrillary acidic protein ; Immunocytochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary To extend earlier observations on Schwann cell remyelination in multiple sclerosis (MS) lesions (Itoyama et al. 1983) we immunostained spinal cord sections from eight Japanese MS patients with antiserum to Po glycoprotein, a major constituent of peripheral nervous system (PNS) myelin, myelin basic protein (MBP), and glial fibrillary acidic protein (GFAP). Spinal cord sections from six of the eight Japanese MS patients contained large clusters of peripheral myelin sheaths with anti-Po immunoreactivity. In lesions found in four of the six patients, thousands of Po-stained PNS myelin sheaths were present. Necrosis was prominent in these lesions which included more than half of the spinal cord's transverse area. The number and density of regenerating myelin sheaths of peripheral origin were much greater than we observed in MS spinal cord lesions of white people (Itoyama et al. 1983). Anti-GFAP immunoreactivity was present in most brain and spinal cord lesions. However, the areas in lesions that contained large groups of PNS myelin sheaths lacked anti-GFAP immunoreactivity. Our data suggest that spinal MS lesions that are large, severely demyelinated, and partially necrotic may contain factors that inhibit fibrous astrogliosis. These factors, other substances in the large lesions and/or the lack of astrocytic scarring could then promote Schwann cell invasion, multiplication, and remyelination of surviving axons.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    ISSN: 1432-0738
    Schlagwort(e): Fenitrothion ; Fenitrooxon ; Acute toxicity ; Phenobarbital ; Adrenalectomy ; Diethyl maleate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effect of adrenalectomy (Adx), SKF 525-A, phenobarbital (PB), and diethyl maleate (DEM) on the acute toxicity of fenitrothion was investigated in male rats by assessing the degree of plasma cholinesterase activity. PB, 60 mg/kg/day for 3 days, exerted no protective effect on the toxicity of fenitrothion (100 mg/kg, p.o.) given 24 h after the last injection. In adrenalectomized and SKF 525-A-pretreated rats, the toxicity of fenitrothion was lower than that of the controls. Fenitrothion toxicity was increased by administration of DEM (1 ml/kg), which depletes hepatic glutathione (GSH) levels. In vitro, the rates of fenitrothion decomposition and fenitrooxon formation by microsomes were markedly affected by PB, SKF 525-A and Adx. The decomposition of fenitrooxon by the microsomal fraction and GSH-dependent decomposition of fenitrooxon by the soluble fraction were not affected by PB, SKF 525-A and Adx pretreatment. The GSH-dependent decomposition of fenitrothion and fenitrooxon was increased by addition of GSH to the incubation mixture. The present results indicate that the GSH-dependent metabolic pathway plays an important role in the detoxication of fenitrothion.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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