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  • Electronic Resource  (4)
  • Skeletal muscle  (2)
  • Arterial oxyhemoglobin saturation  (1)
  • Blood pH  (1)
  • 1
    ISSN: 1439-6327
    Keywords: Electrolytes ; Fluid balance ; Glucose ; Exercise metabolism ; Blood pH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of these experiments was to examine the influence of various fluid replacement drinks on exercise-induced disturbances in homeostasis during heavy exercise. Nine trained cyclists performed constant load exercise on a cycle ergometer to fatigue on three occasions with 1-week separating experiments. The work rate was set initially at ∼ 85% of $$\dot V_{o_{2{\text{ }}max} } $$ (range 82–88%) with fatigue being defined as a 10% decline in power output below the initial value. During each experiment subjects consumed one of the following three beverages prior to and every 15 min during exercise: (1) non-electrolyte placebo (NEP; 31 mosmol · kg−1); (2) glucose polymer drink containing electrolytes (GP; 7% CHO, 231 mosmol · kg−1), and (3) electrolyte placebo drink without carbohydrate (EP; 48 mosmol · kg−1). Both the GP and EP beverage contained sodium citrate/citric acid (C) as a flavoring agent while C was not contained in the NEP drink. Although seven of nine subjects worked longer during the GP and EP treatment when compared with the NEP trial, the difference was not significant (P〉0.05). No differences (P〉0.05) existed between the GP and EP treatments in performance time. Exercise changes in rectal temperature, heart rate, Δ % plasma volume and plasma concentrations of total protein, free fatty acids, glucose, lactate, potassium, chloride, calcium, and sodium did not differ (P〉0.05) between trials. In contrast, blood hydrogen ion concentration [H+] was significantly lower (P〈0.05) at 30 min of exercise during the GP and EP treatment when compared with the NEP run. These data provide evidence that electrolyte drinks do not minimize exercise-induced disturbances in blood-electrolyte concentrations during heavy execrcise when compared with nonelectrolyte drinks; however, these results suggest that fluid replacement beverages containing buffers (i.e. C) and/or electrolytes may minimize blood alterations in [H+] during intense exercise. Additional research is required to determine if the buffering influence of these beverages has an ergogenic benefit during heavy exercise.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1439-6327
    Keywords: Exercise ; Induced hypoxemia ; Incremental exercise ; Trained athletes ; Arterial oxyhemoglobin saturation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent evidence suggests that exercise-induced hypoxemia (EIH) may occur in healthy trained endurance athletes. However, at present, no data exist to describe the regularity of EIH in athletes or non-athletes. Therefore, the purpose of the present investigation was to determine the incidence of EIH during exercise in healthy subjects varying in physical fitness. Subjects (N=68) performed an incremental cycle ergometer test to volitional fatigue with percent arterial oxyhemoglobin saturation (%SaO2) measured min-by-min. For the purpose of data analysis subjects were divided into three groups according to their level of physical training: 1) untrained (N=16), 2) moderately trained (N=27), and 3) elite highly trained endurance athletes (N=25). EIH was defined as a %SaO2 of ≤91% during exercise. EIH did not occur in any of the untrained subjects or the moderately trained subjects. However, EIH occurred in 52% of the highly trained endurance athletes tested and was highly reproducible (r=0.95; P〈0.05). These findings further confirm the existence of EIH in healthy highly trained endurance athletes and suggests a rather high incidence of EIH in this healthy population. Hence, it is important that the clinician or physiologist performing exercise testing in elite endurance athletes recognize that EIH can and does occur in the elite endurance athlete in the absence of lung disease.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 74 (1996), S. 391-396 
    ISSN: 1439-6327
    Keywords: β(2)-Adrenoceptor agonist ; Skeletal muscle ; Fiber type ; Myosin heavy chain isoforms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study examined the effects of 6 weeks of treatment with theβ (2)-adrenoceptor agonist, clenbuterol, on the soleus muscle of adult female Sprague-Dawley rats. Animals (4 months old) were divided into two groups: clenbuterol treated (CL,n=7) (2 mg kg−1 body mass injected subcutaneously every other day), and control (CON,n=7) (injected with isotonic saline). Post-treatment body weights were ≈ 5% greater in the CL group compared to CON (P〈0.05). Polyacrylamide gel electrophoresis (SDS-PAGE) of soleus myofibrillar protein indicated a clenbuterol-induced decrease (P〈0.05) in the relative percentage of type I myosin heavy chain (MHC) with a concomitant increase (P〈0.05) in type IIdx MHC, while the proportion of type IIa MHC was unaffected. ATPase fiber typing revealed increases (P〈0.05) in the proportion of type II fibers expressed both as a percentage of total fiber number and total cross-sectional area (CSA). Finally, mean type II fiber CSA was ≈25% greater (P〈0.05) in the CL groups as compared to the CON group. These data indicate that clenbuterol treatment results in alterations in the MHC phenotype and an increased proportion of type II fiber CSA in the soleus of adult rats. These observations were due to an increase in the total number of type II fibers, as well as hypertrophy of these fibers. Thus, the relative increase in the number of histochemically determined type II fibers and the emergence of the normally unexpressed type IIdx MHC isoform in the soleus suggest a clenbuterol-induced transition of muscle fiber phenotype as well as selective hypertrophy of the type 11 fibers.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 74 (1996), S. 391-396 
    ISSN: 1439-6327
    Keywords: Key words β(2)-Adrenoceptor agonist ; Skeletal muscle ; Fiber type ; Myosin heavy chain isoforms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  This study examined the effects of 6 weeks of treatment with the β(2)-adrenoceptor agonist, clenbuterol, on the soleus muscle of adult female Sprague-Dawley rats. Animals (4 months old) were divided into two groups: clenbuterol treated (CL, n=7) (2 mg·kg–1 body mass injected subcutaneously every other day), and control (CON, n=7) (injected with isotonic saline). Post-treatment body weights were ≈5% greater in the CL group compared to CON (P〈0.05). Polyacrylamide gel electrophoresis (SDS-PAGE) of soleus myofibrillar protein indicated a clenbuterol-induced decrease (P〈0.05) in the relative percentage of type I myosin heavy chain (MHC) with a concomitant increase (P〈0.05) in type IIdx MHC, while the proportion of type IIa MHC was unaffected. ATPase fiber typing revealed increases (P〈0.05) in the proportion of type II fibers expressed both as a percentage of total fiber number and total cross-sectional area (CSA). Finally, mean type II fiber CSA was ≈25% greater (P〈0.05) in the CL groups as compared to the CON group. These data indicate that clenbuterol treatment results in alterations in the MHC phenotype and an increased proportion of type II fiber CSA in the soleus of adult rats. These observations were due to an increase in the total number of type II fibers, as well as hypertrophy of these fibers. Thus, the relative increase in the number of histochemically determined type II fibers and the emergence of the normally unexpressed type IIdx MHC isoform in the soleus suggest a clenbuterol-induced transition of muscle fiber phenotype as well as selective hypertrophy of the type II fibers.
    Type of Medium: Electronic Resource
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