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1

Electronic Resource

High density lipoprotein mediates selective reduction in cholesteryl esters from macrophage foam cells

Miyazaki, A. ; Rahim, A.T.M.A. ; Ohta, T. ; [et al.]

Amsterdam : Elsevier

Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 1126 (1992), S. 73-80

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ISSN: 0005-2760

Keywords: Cholesteryl ester ; Foam cell ; HDL receptor ; High density lipoprotein ; Macrophage

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Medicine , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/0005-2760(92)90219-L

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2

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Scavenger receptor-mediated recognition of maleylated albumin and its relation to subsequent endocytic degradation

Takata, K. ; Horiuchi, S. ; Morino, Y.

Amsterdam : Elsevier

Biochimica et Biophysica Acta (BBA)/Biomembranes 984 (1989), S. 273-280

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ISSN: 0005-2736

Keywords: (Rat) ; Acetylated LDL ; Endocytosis ; Liver metabolism ; Macrophage ; Maleylated bovine serum albumin ; Receptor-mediated endocytosis ; Scavenger receptor

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Medicine , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/0005-2736(89)90293-9

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3

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Purification and properties of β-cyano-l-alanine synthase from Vicia angustifolia

Ikegami, F. ; Takayama, K. ; Kurihara, T. ; [et al.]

Amsterdam : Elsevier

Phytochemistry 28 (1989), S. 2285-2291

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ISSN: 0031-9422

Keywords: Leguminosae ; O-acetyl-l-serine ; Vicia angustifolia ; amino acid composition ; cysteine synthase ; distribution ; enzyme purification ; heterocyclic β-substituted alanines ; higher plants. ; l-cysteine ; substrate specificity ; β-cyano-l-alanine ; β-cyano-l-alanine synthase

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/S0031-9422(00)97969-X

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4

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Biosynthesis of neuroactive amino acids by cysteine synthases in Lathyrus latifolius

Ikegami, F. ; Horiuchi, S. ; Kobori, M. ; [et al.]

Amsterdam : Elsevier

Phytochemistry 31 (1992), S. 1991-1996

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ISSN: 0031-9422

Keywords: Lathyrus latifolius ; Leguminosae ; biosynthesis ; cysteine synthase ; enzyme purification ; heterocyclic β-substituted alanines ; higher plants. ; l-quisqualic acid ; neuroactive amino acids ; substrate specificity ; β-cyano-l-alanine ; β-cyanoalanine synthase

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(92)80347-H

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5

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Intracellular accumulation of cholesteryl esters suppresses production of lipopolysaccharide-induced interleukin 1 by rat peritoneal macrophages

Haga, Y. ; Takata, K. ; Araki, N. ; [et al.]

Amsterdam : Elsevier

Biochemical and Biophysical Research Communications 160 (1989), S. 874-880

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ISSN: 0006-291X

Keywords: BSA; bovine serum albumin ; IL-1; interleukin 1 ; LDL; low density lipoprotein ; LPS; lipopolysaccharide ; PBS; phosphate buffered saline ; acetyl-LDL; acetylated LDL ; maleyl-BSA; maleylated BSA

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/0006-291X(89)92516-3

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6

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Intracellular accumulation of cholesteryl esters suppresses production of lipopolysaccharide-induced interleukin 1 by rat peritoneal macrophages

Haga, Y. ; Takata, K. ; Araki, N. ; [et al.]

Amsterdam : Elsevier

Biochemical and Biophysical Research Communications 160 (1989), S. 874-880

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ISSN: 0006-291X

Keywords: BSA; bovine serum albumin ; IL-1; interleukin 1 ; LDL; low density lipoprotein ; LPS; lipopolysaccharide ; PBS; phosphate buffered saline ; acetyl-LDL; acetylated LDL ; maleyl-BSA; maleylated BSA

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/0006-291X(89)92516-3

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7

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Partial purification and characterization of CA19-9 antigen from the ascitic fluid of a patient with pancreatic cancer

Haga, Y. ; Horiuchi, S. ; Morino, Y. ; [et al.]

Amsterdam : Elsevier

Clinical Biochemistry 22 (1989), S. 363-368

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ISSN: 0009-9120

Keywords: CA125 antigen ; CA19-9 antigen ; pancreatic cancer ; tumor markers

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Medicine

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/S0009-9120(89)80033-5

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8

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Partial purification and characterization of CA19-9 antigen from the ascitic fluid of a patient with pancreatic cancer

Haga, Y. ; Horiuchi, S. ; Morino, Y. ; [et al.]

Amsterdam : Elsevier

Clinical Biochemistry 22 (1989), S. 363-368

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ISSN: 0009-9120

Keywords: CA125 antigen ; CA19-9 antigen ; pancreatic cancer ; tumor markers

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Medicine

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/S0009-9120(89)80033-5

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9

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The relationship between accumulation of advanced glycation end products and expression of vascular endothelial growth factor in human diabetic retinas (1997)

Murata, T. ; Nagai, R. ; Ishibashi, T. ; [et al.]

Springer

Diabetologia 40 (1997), S. 764-769

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ISSN: 1432-0428

Keywords: Keywords Advanced glycation end products ; blood retinal barrier ; diabetic retinopathy ; Ne-(carboxymethyl)lysine ; vascular endothelial growth factor.

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Both advanced glycation end products and vascular endothelial growth factor are believed to play a role in the pathogenesis of diabetic retinopathy. It is known that vascular endothelial growth factor causes retinal neovascularization and a breakdown of the blood-retinal barrier; how advanced glycation end products affect the retina, however, remains largely unclear. The substance Ne-(carboxymethyl)lysine is a major immunologic epitope, i. e. a dominant advanced glycation end products antigen. We generated an anti-Ne-(carboxymethyl)lysine antibody to investigate the relationship between the localization of advanced glycation end products and that of vascular endothelial growth factor in 27 human diabetic retinas by immunohistochemistry. Nine control retinas were also examined. In all 27 diabetic retinas, Ne-(carboxymethyl)lysine was located in the thickened vascular wall. In 19 of the 27 retinas, strand-shaped Ne-(carboxymethyl)lysine immunoreactivity was also observed around the vessels. In all 27 diabetic retinas, vascular endothelial growth factor revealed a distribution pattern similar to that of Ne-(carboxymethyl)lysine. Vascular endothelial growth factor was also located in the vascular wall and in the perivascular area. Neither Ne-(carboxymethyl)lysine nor vascular endothelial growth factor immunoreactivity was detected in the 9 control retinas. Vessels with positive immunoreactivity for Ne-(carboxymethyl)lysine and/or vascular endothelial growth factor were counted. A general association was noted between accumulation of Ne-(carboxymethyl)lysine and expression of vascular endothelial growth factor in the eyes with non-proliferative diabetic retinopathy (p 〈 0.01) and proliferative diabetic retinopathy (p 〈 0.05). [Diabetologia (1997) 40: 764–769]

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s001250050747

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10

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Advanced glycation end products-cytokine-nitric oxide sequence pathway in the development of diabetic nephropathy: aminoguanidine ameliorates the overexpression of tumour necrosis factor-α and inducible nitric oxide synthase in diabetic rat glomeruli (1999)

Sugimoto, H. ; Shikata, K. ; Wada, J. ; [et al.]

Springer

Diabetologia 42 (1999), S. 878-886

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ISSN: 1432-0428

Keywords: Keywords Advanced glycation end products ; aminoguanidine ; nitric oxide ; diabetic nephropathy.

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Aims/hypothesis. Advanced glycation end products are believed to contribute to diabetic microvascular complications by inducing glomerular damage but their role has not been fully clarified. In this study, we explain their central role in the induction of inducible nitric oxide synthase and production of nitric oxide (NO) in streptozotocin-induced diabetic rat glomeruli. Methods. Localization of carboxymethyllysine, which is one of the chemical components of advanced glycation end products, glomerular expression of inducible nitric oxide synthase and urinary excretion and glomerular production of NO2 –/NO3 – were examined at 0, 26, 51, and 52 weeks after the induction of diabetes. Therapeutic effects of aminoguanidine were also examined. Results. Carboxymethyllysine was detected in the mesangial area in glomeruli and it progressively accumulated during 52 weeks of observation. Immunohistochemistry and hybridization studies in situ showed that the number of inducible nitric oxide synthase-positive cells was notably increased in diabetic rat glomeruli at 52 weeks. Further, this augmented expression paralleled intraglomerular expression of TNF-α and NO2 –/NO3 – in diabetic rat glomeruli. Treatment with aminoguanidine reduced the expression of TNF-α, inducible nitric oxide synthase and intraglomerular NO2 –/NO3 – production. It also ameliorated proteinuria in diabetic rats. Conclusion/interpretation. This study showed that carboxymethyllysine possibly enhances the expression of inducible nitric oxide synthase by stimulating the expression of TNF-α in diabetic rat glomeruli. The carboxymethyllysine-cytokine-NO sequence pathway could be one of the major mechanisms in the development of diabetic nephropathy. [Diabetologia (1999) 42: 878–886]

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s001250051241

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