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  • 1
    Electronic Resource
    Electronic Resource
    Prognostic significance of apoptosis and associated factors in oral squamous cell carcinoma (2000)
    Springer
    Virchows Archiv 436 (2000), S. 102-108 
    Details
    ISSN: 1432-2307
    Keywords: Key words Oral ; Squamous cell carcinoma ; Proliferation ; Apoptosis ; Tumour suppressor gene ; Oncogene ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Tumour progression is characterised by an imbalance between cell proliferation and apoptosis. The aim of our study was to estimate the importance of proliferation and apoptosis associated parameters in primary squamous cell carcinomas (SCCs) of the oral cavity and oropharynx. For determination of apoptosis, the enzymatic labelling of DNA fragmentation with a terminal transferase reaction was used in 156 tissue samples of 107 patients, including corresponding lymph-node metastases in nine cases. P53, bcl-2, and Ki-67 were determined immunohistologically. P53 was detectable in 50.5% of the cases. Positive staining was associated significantly with decreased apoptosis (P〈0.003). Bcl-2 was upregulated in 31.8% of the cases depending on the tumour grading (P〈0.001) and correlated negatively with apoptosis (P〈0.001). Proliferation (P〈0.006) and apoptosis (P〈0.03) were enhanced in larger tumours, though a direct correlation between these two parameters was not proven. Nevertheless, in contrast to the conventional tumour staging and grading, neither the expression of p53 or bcl-2 nor the apoptosis or Ki-67 measurements were able to predict survival or recurrence-free survival of the patients suffering from a SCC in the oral cavity or oropharynx. Our observations suggest that the function of wild-type p53 to induce apoptosis is lost in at least half of the SCCs under study and that the physiological function of bcl-2 as potent inhibitor of apoptosis is widely preserved in oral SCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008207
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  • 2
    Electronic Resource
    Electronic Resource
    Mitosen beim Uteruscarcinom (1957)
    Springer
    Archives of gynecology and obstetrics 189 (1957), S. 403-404 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00990713
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  • 3
    Electronic Resource
    Electronic Resource
    Large Nicol Prisms (1899)
    [s.l.] : Nature Publishing Group
    Nature 61 (1899), S. 31-32 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN the account of Dr. Spottiswoode's physical apparatus, lately given to the Royal Institution, there are allusions to several large Nicol prisms said to have been made by Mr. Ladd and by Messrs. Sisley and Spiller. Although it is no doubt the trade custom to mention only the names of opticians ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/061031d0
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  • 4
    Electronic Resource
    Electronic Resource
    Convexity and the Beta Invariant (1999)
    Springer
    Discrete & computational geometry 22 (1999), S. 411-424 
    Details
    ISSN: 1432-0444
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract. We apply a generalization of Crapo's β invariant to finite subsets of R n. For a finite subset C of the plane, we prove β(C)=|int (C)|, where |int (C)| is the number of interior points of C, i.e., the number of points of C which are not on the boundary of the convex hull of C . This gives the following formula: ΣK free (-1) |K|-1 |K|=|int(C)|.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00009469
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  • 5
    Electronic Resource
    Electronic Resource
    Prästernales verruköses Karzinom (2000)
    Springer
    Der Hautarzt 51 (2000), S. 766-769 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Verruköses Karzinom ; Ackerman-Tumor ; Buschke-Löwenstein-Tumor ; Epithelioma cuniculatum ; Keywords Verrucous carcinoma ; Ackerman's tumor ; Buschke-Löwenstein tumor ; Epithelioma cuniculatum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Verrucous carcinomas represent rare, highly differentiated variants of squamous cell carcinoma. They preferentially develop on the oropharyngeal mucosa (Ackerman tumor), the urogenital mucosa (Buschke-Loewenstein tumors), and the soles of the feet (epitheliomata cuniculata). Various synonyma have been coined for these tumors. We report the uncommon occurrence of a large verrucous carcinoma on apparently uninvolved chest skin of a 79-year old patient. The tumor was excised radically. Complete extirpation was confirmed histologically and there was no sign of recurrence during a 3 month observation period. The clinical appearance, histomorphological features, epidemiological aspects, differential diagnosis, therapy, and nomenclature of verrucous carcinomas are discussed.
    Notes: Zusammenfassung Verruköse Karzinome repräsentieren seltene Sonderformen hochdifferenzierter Plattenepithelkarzinome. Sie treten bevorzugt an der oropharyngealen Mukosa (Ackerman-Tumoren), der urogenitalen Mukosa (Buschke-Löwenstein-Tumoren) und den Fußsohlen (Epitheliomata cuniculata) auf. Verschiedene Synonyme sind gebräuchlich für verruköse Karzinome unterschiedlicher Lokalisation. Wir berichten über das ungewöhnliche Auftreten eines großen verrukösen Karzinoms auf primär unbefallener Brusthaut bei einem 79-jährigen Patienten. Der Tumor wurde, histologisch kontrolliert, vollständig exzidiert, und in der bis jetzt 3-monatigen Nachbeobachtungsphase fand sich kein Anhalt für ein Rezidiv. Anhand dieses Falls werden klinische Erscheinungsformen, histomorphologische Charakteristika, epidemiologische Aspekte, Differenzialdiagnose, Therapie und Nomenklatur verruköser Karzinome diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050051212
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  • 6
    Electronic Resource
    Electronic Resource
    Ueber die Bestimmung von schwefliger Säure und Schwefelsäure in den Verbrennungsproducten des Leuchtgases (1896)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 35 (1896), S. 1-10 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01415232
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  • 7
    Electronic Resource
    Electronic Resource
    Phosphate und phosphorhaltige Düngemittel (1935)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 102 (1935), S. 222-235 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01362731
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  • 8
    Electronic Resource
    Electronic Resource
    Zur Perchloratbestimmung im Chilesalpeter (1900)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 13 (1900), S. 419-419 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19000131705
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  • 9
    Electronic Resource
    Electronic Resource
    Ueber die Einwirkung von salpetriger Säure auf Inden und Cumaron (1895)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 28 (1895), S. 1331-1335 
    Details
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.18950280217
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