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  • 1995-1999  (8)
  • 1975-1979  (3)
  • 1960-1964  (1)
  • 1999  (8)
  • 1977  (3)
  • 1964  (1)
  • 1
    Electronic Resource
    Electronic Resource
    3′,5′-Cyclic Guanosine Monophosphate Activates Mitogen-Activated Protein Kinase in Rat Pinealocytes (1999)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 73 (1999), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract : The role of 3′,5′-cyclic guanosine monophosphate (cGMP) in the activation of mitogen-activated protein kinases (MAPKs) was investigated in rat pinealocytes. Treatment with dibutyryl cGMP (DBcGMP) dosedependently increased the phosphorylation of both p44 and p42 isoforms of MAPK. This effect of DBcGMP was abolished by PD98059 (a MAPK kinase inhibitor), H7 (a nonspecific protein kinase inhibitor), and KT5823 [a selective cGMP-dependent protein kinase (PKG) inhibitor]. Elevation of cellular cGMP content by treatment with norepinephrine, zaprinast (a cGMP phosphodiesterase inhibitor), or nitroprusside was effective in activating MAPK. Natriuretic peptides that were effective in elevating cGMP levels in this tissue were also effective in activating MAPK. Our results indicate that, in this neuroendocrine tissue, the cGMP/PKG signaling pathway is an important mechanism used by hormones and neurotransmitters in activating MAPK.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1999.0730598.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    ANTIARRHYTHMIC PROPERTIES OF 5-(3-TERT-BUTYLAMINO-2-HYDROXY)PROPOXY-3,4-DIHYDRO-CARBOSTYRIL HYDROCHLORIDE (OPC- 1085), A NEWLY SYNTHESIZED, POTENT β-ADRENORECEPTOR ANTAGONIST (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 4 (1977), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The antiarrhythmic properties of 5–(3-tert-butylarnino-2-hydroxy)propoxy-3,4-dihydrocarbostyril hydrochloride (OPC-1085) were compared with those of propranolol and pindolol using various kinds of preparations for experimental arrhythmia in dogs.2. Although OPC-1085 was the most potent drug to antagonize adrenaline-induced arrhythmia in animals anaesthetized with either pentobarbitone sodium or halothane, it was scarcely effective on ouabain-induced arrhythmia in pentobarbitone sodium anaesthetized animals.3. When these compounds were administered intravenously to conscious dogs 24 h after two-stage ligation of the anterior descending artery, ectopic ventricular beats of coronary ligation-induced arrhythmia were reduced while regular sinus beats were simultaneously increased.4. OPC-1085 was very effective on aconitine-induced arrhythmia in dogs anaesthetized with pentobarbitone sodium. The effective dose was similar to that of propranolol but about fifteen times less than that of pindolol.5. It is concluded that different potencies among these β-adrenoreceptor antagonists against various kinds of experimental arrhythmias cannot be simply deduced from any one of the following properties; β-adrenoreceptor antagonism, intrinsic myocardial stimulation, local anaesthetic and so-called quinidine-like effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1977.tb02684.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Anodically deposited manganese-molybdenum oxide anodes with high selectivity for evolving oxygen in electrolysis of seawater (1999)
    Springer
    Journal of applied electrochemistry 29 (1999), S. 769-775 
    Details
    ISSN: 1572-8838
    Keywords: anodic deposition ; manganese-molybdenum oxide electrode ; oxygen evolution ; seawater electrolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Manganese-molybdenum oxide electrodes were prepared by anodic deposition on an IrO2-coated titanium substrate at a constant current density of 600Am−2 from baths containing 0.2M MnSO4 and 0–0.1M Na2MoO4 at 90∘C and pH 0.5. These electrodes were characterised for oxygen evolution in the electrolysis at 1,000Am−2 in 0.5M NaCl solution at 30∘C and pH 8 or 12. The most active and stable oxygen evolving anode exhibited 100% efficiency for oxygen evolution, and an efficiency of 98.5% for over 1,500 h at pH 12 and of 96.5% for over 2,800 h at pH 8 of continuous electrolysis. X-ray diffraction measurement and XPS analysis indicated that the deposits consist of a nanocrystalline single γ-MnO2 type phase, and manganese and molybdenum in the deposits are in the Mn4+ and Mo6+ states. The electrochemical studies showed that the manganese-molybdenum oxide electrodes drastically reduced the electrocatalytic activity for chlorine evolution to the undetectable level, resulting in 100% efficiency for oxygen evolution, although the addition of molybdenum slightly increased the oxygen overpotential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003492009263
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The chemoreflex induced by intraarterial injection of Aza-azepinophenothiazine, veratridine and bradykinin into femoral and brachial arteries of innervated and divided limbs of a dog (1964)
    Springer
    Cellular and molecular life sciences 20 (1964), S. 394-396 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Reflektorische Blutdrucksteigerung wurde durch intraarterielle Injektion von Tetrahydro-azaazepinophenothiazin und Veratridin am Präparat des innervierten Hinterbeins vom Hund hervorgerufen. Während kleine Dosen von Bradykinin nur leichte Blutdrucksenkung verursacht, führen grössere Dosen zu nachhaltigem Blutdruckanstieg. Bei Abhäuten des Hinterbeinpräparates unterblieb der Primäreffekt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02147987
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Linkages between chromophore and apoprotein in the biliverdin-protein of the scales of big blue parrotfish, Scarus gibbus Rüppell (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 583-584 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary On the basis of the amino acid composition of the chromophore peptides, it can be assumed that Asp, Ser and 1/2 Cys are located near the biliverdin chromophore. Experiments for splitting of the chromophore lead us to expect a thioether bond in the linkages between biliverdin and apoprotein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946509
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Maturation defect of a temperature-sensitive mutant of western equine encephalitis virus (1977)
    Springer
    Archives of virology 53 (1977), S. 209-219 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The defective step of a temperature-sensitive mutant of western equine encephalitis virus, which synthesize viral RNA but not mature virus at the restrictive temperature, was studied. Cells infected with the mutant virus at the restrictive temperature synthesized the same intracellular viral RNA as that in wild type infection. Cells infected with the mutant at the restrictive temperature formed three proteins (E1, E2 and C) which migrated to positions identical with those of purified virions and a precursor protein of E2 (PE2). The mutant virus was also able to form cytoplasmic nucleocapsids sedimenting at 140S as in the case of wild type infection. On the other hand, cells infected with the mutant could not induce a significant amount of hemadsorbing ability and the ability induced at the permissive temperature disappeared immediately after shifting up to the restrictive temperature. These results suggested that the mutant virus produced a defective envelope protein responsible for hemagglutination at the restrictive temperature. Owing to the incompleteness of the modification of the cell plasma membrane by the envelope proteins, viral nucleocapsids in the mutant infected cells could not bind to the plasma membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314665
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    A Comparison of the Plasma Fructose Concentrations in Dogs and Cats and Changes in the Fructose Concentrations in Dogs Following Intravenous Administration of Fructose (1999)
    Springer
    Veterinary research communications 23 (1999), S. 203-209 
    Details
    ISSN: 1573-7446
    Keywords: cat ; dog ; free fatty acids ; fructose ; glucose ; plasma ; triglycerides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The plasma concentrations of fructose, glucose, free fatty acids (FFA) and triglycerides (TG) were measured in dogs and cats. Changes in these concentrations were investigated in dogs by an intravenous fructose tolerance test (IVFTT) at a dose of 0.1 g/kg body weight. Fructose concentrations in the plasma of dogs were significantly higher than those of cats. There was no significant difference in plasma glucose concentrations between dogs and cats. Plasma FFA concentrations decreased and TG concentrations increased after feeding in both dogs and cats. During the IVFTT, the plasma fructose concentrations in the dogs increased rapidly to a peak by 2 min and then decreased to half of the peak by 5 min after the administration of fructose. Administration of fructose resulted in an increase in the plasma TG concentrations and reduced plasma FFA concentrations in the dogs. Only 4% of the administered fructose was detected in the urine of dogs following IVFTT. Plasma fructose was considered to be rapidly absorbed and metabolized in both dogs and cats. However, as with glucose metabolism, there appear to be some differences in fructose metabolism between dogs and cats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006203807735
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Antineutrophil Cytoplasmic Antibody in Patients with Primary Sjo¨gren’s Syndrome (1999)
    Springer
    Clinical rheumatology 18 (1999), S. 268-271 
    Details
    ISSN: 1434-9949
    Keywords: Key words:Antilactoferrin antibody – Antimyeloperoxidase antibody – Autoantibody – Polyclonal B-cell activation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The incidence, specificity and clinical significance of positivity for serum antineutrophil cytoplasmic antibody (ANCA) was investigated in 60 patients with primary Sjögren’s syndrome (SjS). The indirect immunofluorescence (IIF) technique and an enzyme-linked immunosorbent assay (ELISA) were used to measure ANCA. Purified myeloperoxidase (MPO), lactoferrin (LF), cathepsin-G (CTG) and elastase (HLE) served as ANCA antigens for the ELISA. Ten (16.7%) of the 60 SjS patients showed positivity by IIF for perinuclear, but not cytoplasmic, ANCA. Four of the 60 sera were shown to be positive for LF, four for MPO, 0 for CTG and 0 for HLE by ELISA. There was no correlation between ANCA positivity and clinical features. ANCA in patients with SjS might be an epiphenomenon of polyclonal B-cell activation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100670050100
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  • 9
    Electronic Resource
    Electronic Resource
    The effect of SiO2 addition in super-hydrophilic property of TiO2 photocatalyst (1999)
    Springer
    Journal of materials science 34 (1999), S. 2569-2574 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The relation between the effect and the amount of SiO2 addition on photo-generated hydrophilicity of TiO2 thin film, was investigated by measuring the X-ray diffraction, the microstructure, the specific surface area and the TG-DTA. It was found that the optimum range existed in the amount of SiO2 addition to TiO2, 10–30 mol % SiO2 addition was most effective for contact angle of water. The SiO2 addition less than 30 mol % has a suppressive effect on the transformation of anatase to rutile and on the crystal growth of anatase in calcination, and it has large surface area. With the consequence that the photocatalytic activity of TiO2 and the capability of holding absorbed water which increases during UV irradiation improved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004644514653
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  • 10
    Electronic Resource
    Electronic Resource
    Study of optimum condition for synthesis of [γ-32P]ATP with high specific radioactivity (1999)
    Springer
    Journal of radioanalytical and nuclear chemistry 239 (1999), S. 423-427 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The synthesis of [γ-32P]ATP with high specific radioactivity was investigated by the enzymatic method. We utilized a part of the glycolytic pathway which consists of three reaction steps. First, we examined the maximum radioactivity of H3 32PO4 without the decrease of labeling yield. Next, we examined the minimum amount of reagent without the decrease of labeling yield, because some reagents contain the phosphorus species as impurity. In this paper, we propose the optimum condition for synthesis of [γ-32P]ATP with high specific radioactivity. As our calculation, we will be able to obtain about 220 TBq/mmol specific radioactivity using 1.5 GBq of H3 32PO4.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02349524
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