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  • 1985-1989  (11)
  • 1970-1974  (4)
  • 1960-1964
  • 1988  (11)
  • 1971  (4)
  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 92 (1988), S. 4636-4640 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 92 (1988), S. 1016-1018 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 92 (1988), S. 4272-4274 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 15 (1988), S. 0 
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 51-year-old imunosuppressed man presented with ulcerations of the abdominal wall. Biopsy of the ulcer margin was necessary for the diagnosis of cutaneous cryptococcosis. Since a variety of opportunistic organisms can present with non-specific cutaneous lesions, these infections must be ruled out by tissue diagnosis of all immunosuppressed patients. A review of 22 additional cases is included together with electron microscopic findings.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 15 (1988), S. 0 
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Specimens from a patient with epidermolysis bullosa contained many elastic globes in the dermis. Ultrastructurally they were composed of (i) medium electron-dense amorphous substances, (ii) electron-dense round structures, and (iii) fine filaments. These various elements were seldom organized into typical normal elastic fiber and, therefore, it was difficult ultrastructurally to recognize them as such or components thereof. Immunohistochemically, elastic globes were strongly reactive with NKH-1, which stains elastic microfibrils, and antibody to serum amyloid P component (anti-SAP), which binds to elastic fiber micro-fibrils. However, elastic globes were negative with EKH-4 which recognizes 50 kd keratin of amyloid keratin and cytoid bodies. These findings suggested that elastic globes have a close immunologic profile to elastic fiber microfibrils, but not that of epidermal or epithelial keratin.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Der Effekt von sechsβ-adrenergischen Blockierungsmitteln auf Akonitin-Arrhythmia bzw. Ouabain-Arrhythmia wurde mittels i.v. Verabreichung vergleichend untersucht. Reihenfolge der Wirksamkeit auf Akonitin-Arrhythmia: Propranolol〉MJ 1999〉LB 46〉H 56/28, ICI 50172 und DCI, und dieselbe auf Ouabain-Arrhythmia: Propranolol, LB 46 und H 56/28 gleichwertig, MJ 1999 und ICI 50172 wirkungslos.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 240 (1971), S. 349-364 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Kleine protoplasmatische Körnchen, welche in verschiedenen verhornenden Epithelien gefunden worden sind und als der Zellmembran aufliegende Körnchen oder Keratinosome bezeichnet wurden, konnten durch Phospholipase C gespalten werden. Körnchen, die in die intercellulären Zwischenräume abgestoßen waren, waren gleichfalls durch Phospholipase C spaltbar. Da angenommen wird, daß Phosphatide einen Teil der intercellularen Kittsubstanz bilden, nicht nur in der Haut, sondern auch in anderen eng zusammengefügten Epithelien, wird die Bezeichnung „Kittkörnchen“ oder „Kittkörper“ für diese Körnchen vorgeschlagen.
    Notes: Summary Small cytoplasmic granules, which have been found in various keratinizing epithelia and called the membrane-coating granules or keratinosomes, were found to be amenable to phospholipase C digestion. Granules discharged into the intercellular spaces could also be digested with phospholipase C. Since it is believed that phospholipids are part of the intercellular cement not only in the skin but in other tightly junctioned epithelia, the name “cement granule” or “cementsome” was proposed for these granules.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 240 (1971), S. 1-22 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Nagelzellen, die von den ventralen, apikalen und dorsalen Anteilen der proximalen Matrix gebildet wurden, rückten in axial-distaler Richtung vorwärts, bis sie amproximalen Verhornungspunkte zusammentrafen. Von diesem Punkte an wurden der proximalen Nagelplatte ununterbrochen Zellen von der ventralen und dorsalen Matrix und vom Nagelbett zugefügt. Bald hörte die dorsale Matrix auf, Nagelzellen zu entwickeln und wurde weiter distal in den hinteren Nagelfalz umgewandelt. Mit der differentialen Phasenkontrast-Apparatur von Zeiss-Nomarski konnte man die Teilung der proximalen Nagelplatte in eine ventrale und dorsale Hälfte erkennen. Nächst der Lunula entwickelte das Nagelbett noch eine weitere deutliche Schicht unter der proximalen ventralen Schicht. Elektronmikroskopisch zeigten alle Nagelzellen, ohne Rücksicht auf ihren Ursprung, Verhornung durch Anhäufung von Fibrillen ohne Bildung von Keratohyalinkörnern. Membrane-coating granules (MCG) entstanden in reichlicher Menge. Sie wurden abgestoßen und bildeten die intercellulßre Kittsubstanz. Das abgestoßene Material erweiterte einige der engen Membranspalten, während es gewöhnliche, klaffende (nicht-spezifische) Zellgrenzen verengte und dadurch 150–180 Å weite intercelluläre Zwischenräume bildete, nämlich dieengen Zellverkittungen. Die engen Zellverkittungen stellten den häufigsten Typ der intercellulären Anlagerung dar, wodurch die verhornten Nagelzellen zusammengehalten wurden. Die dicke Zellhülle der verhornten Zellen, nämlich dasGrenzband, wurde durch Niederschlag von dichtem Material an der protoplasmatischen Seite der Zellmembran gebildet und nicht durch die membrane-coating granules.
    Notes: Summary The nail cells produced in the ventral, apical and dorsal portions of the proximal matrix moved in axiodistal direction to meat together at theproximal point of keratinization. The proximal nail plate from this point on was added continuously by the cells from ventral matrix and nail bed. Dorsal matrix soon ceased to produce nail cells and further distally transformed into the posterior nail fold. With Zeiss-Nomarski differential interference contrast equipment, the proximal nail plate could be divided into the ventral and dorsal halves. Near the lunula the nail bed produced one more distinct layer beneath the proximal ventral layer. Electron miscroscopically all nail cells regardless of their origins were seen keratinizing by accretion of tonofibrils without formation of keratohyaline granules. Membrane-coating granules (MGG's) were produced in abundance. They were discharged and provided the intercellular cement. The discharged material widened some of the gap junctions while it tightened nonspeccific junctions to produce 150–180 Å intercellular spaces, i.e. thenarrow junctions. The narrow junctions were the most common type of intercellular junction connecting the keratinized nail cells. The thick cellular envelope of the keratinized cells, i.e. themarginal band, was formed by a precipitation of dense material on the cytoplasmic side of the plasma membranes and not by discharged MCG's.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 280 (1988), S. 308-318 
    ISSN: 1432-069X
    Keywords: Pili annulati ; Ultrastructure ; DACM staining ; Hair cortex ; Protein metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plucked scalp hairs and hair roots of pili annulati were examined to understand their pathogenesis. Stereoscopic examinations of hairs in transmitted light and/or reflected light and light microscopic surveys of the cross-sections of hairs confirmed that the cortical empty spaces appeared to be responsible to the unique dotted shiny appearance of the hairs seen by the unaided eyes under a refracted light. By transmission electron microscope, small vacuoles and dense bodies were observed in the cytoplasm of the differentiating cortical cells; subsequently, with increasing number of tonofilaments, an uneven distribution of free ribosomes occurred and abnormal spaces containing fine granular substances were formed in the cytoplasm of the cortical cells. Occasionally, extremely large cortical trichohyaline granules were found. In the keratinized hair, irregular empty spaces were present in the cortex of the abnormal hair segments. Histochemically, the keratinized cortex of the affected hairs always had more residual SH groups than the controls. Pili annulati may be a disorder of protein metabolism involving a partial dysfunction of cytoplasmic ribosomes, resulting in a lack of cortical keratin formation.
    Type of Medium: Electronic Resource
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