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  • 2000-2004  (1)
  • 1970-1974  (2)
  • 2004  (1)
  • 1972  (2)
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  • 2000-2004  (1)
  • 1970-1974  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Interleukin-18 levels in induced sputum are reduced in asthmatic and normal smokers (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background IL-18 is a cytokine which is known to have an important role in the development of a Th1 lymphocyte response. As such, it may have a regulatory role in asthma by modifying Th2 lymphocyte responses. Cigarette smoking may amplify the airway inflammation associated with asthma.Objective This study investigated if IL-18 could be detected in induced sputum from asthmatics and normal subjects and if smoking altered IL-18 levels.Methods Induced sputum was obtained from asthmatic (31 smokers, 35 non-smokers) and normal (20 smokers, 20 non-smokers) subjects. All smokers had a smoking history of 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:09547894:CEA1973:ges" location="ges.gif"/〉15 pack years. IL-18 levels in sputum supernatant were measured by ELISA. IL-18 mRNA expression and cellular localization were assessed by quantitative PCR and immunocytochemistry, respectively.Results Smoking was associated with a significant reduction in IL-18 levels (median (interquartile range) – smokers 20 (0–102) pg/mL vs. non-smokers 358 (50–876) pg/mL, P〈0.001). This was more pronounced in asthmatics (smokers, 47 (40–64) pg/mL vs. non-smokers, 530 (30–1484) pg/mL; P〈0.001) than in normal subjects (smokers, 25 (0–78) pg/mL vs. non-smokers, 247 (50–656) pg/mL; P〈0.01). Within each of the smoking and non-smoking groups there was no significant difference in IL-18 levels between asthmatic and normal subjects. There was no correlation between sputum IL-18 levels and any specific cell type in the sputum samples nor serum IgE levels. IL-18 mRNA expression was reduced in asthmatic smokers compared with non-smokers. IL-18 production was localized to sputum macrophages by immunocytochemistry.Conclusions IL-18 is detectable in induced sputum samples from both asthmatic and normal subjects. Cigarette smoking significantly reduces sputum IL-18 levels. This effect is more pronounced in asthmatics than in normal subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.01973.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A CASE OF TINEA NIGRA IN BRITAIN (1972)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 87 (1972), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A case of tinea nigra occurring in a Caucasoid girl aged 10 is described. The infection was probably contracted in Malaya where she had lived between the ages of 2 and 4½. The course of the infection was chronic and protracted, with a tendency to recur after apparent cure. The mycological features are described and the aetiology is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1972.tb01600.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of divinyl ether-maleic anhydride (pyran) on foot-and-mouth disease virus infection: Effect on adsorption and multiplication in mouse tissues (1972)
    Springer
    Archives of virology 36 (1972), S. 232-239 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mechanism of resistance to foot-and-mouth disease virus (FMDV) which occurs 2 days after divinyl ether-maleic only anhydride (pyran copolymer) treatment but diminishes by the 7th day was investigated. Adsorption of virus by minced infant mouse spleen, muscle, kidney, heart or liver was not affected either at 2 days or 7 days after treatment of the mice with pyran. However,in vitro multiplication of FMDV in minced kidney was affected by pyran at both times. The resistance of mice 2 days after treatment was related to absence of virus in muscle, kidney, and spleen tissues. Seven days after pyran administration, however, FMDV was recovered from muscle and spleen but not kidney. Interferon was recovered from various tissues 2 days but not 7 days after mice were injected with pyran. Other unknown polymer-induced antiviral factors as well as interferon may have been related to the resistance mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01249854
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    Paper (German National Licenses)
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