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  • 1
    Electronic Resource
    Electronic Resource
    CYCLIC 3′5′-ADENOSINE MONOPHOSPHATE AND CENTRAL CIRCULATORY CONTROL IN CATS AND DOGS (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 4 (1977), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Dibutyryl cyclic AMP (Db CAMP, 75–500 μg/kg), injected into the lateral ventricle of the brain of the cat increased blood pressure, heart rate and splanchnic discharge rate.2. ATP, but not AMP, induced similar changes; GMP in small doses increased blood pressure.3. A number of drugs are known to activate adenylate cyclase-induced hypertension, tachycardia and increase splanchnic discharge rate. This was shown for TRH, tetracosactide and a new β2-adrenoceptor stimulant, NAB 365.4. Injection into the lateral ventricle of theophylline or Ro 7/ 2956, both inhibitors of phosphodiesterase, similarly increased blood pressure.5. Histamine administered by the same route induced similar reactions; it is not known if this action was exerted by activation of H1- or H2-receptors.6. Somatostatin, known to reduce cAMP levels, induced a small but significant decrease in blood pressure. Melanocyte stimulating hormone release inhibiting factor (MIF) and TSH were ineffective.7. These results provide evidence for the possibility of a role for cAMP in the central regulation of blood pressure at suprabulbar levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1977.tb02671.x
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  • 2
    Electronic Resource
    Electronic Resource
    Central sites and mechanisms of the hypotensive and bradycardic effects of the narcotic analgesic agent fentanyl (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 296 (1977), S. 255-261 
    Details
    ISSN: 1432-1912
    Keywords: Baroreceptor reflex arc ; Carotid sinus nerve ; Centrally mediated vagal bradycardia ; Fentanyl ; Nucleus of the solitary tract
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In dogs, anaesthetized with chloralose, fentanyl (5 μg/kg i.v.) augmented the bradycardia produced by electrical stimulation of the carotid sinus nerves. In contrast, the same dose of the drug did not change the bradycardic response to stimulation of the nucleus of the solitary tract (NTS) indicating that a central facilitation of baroreceptor impulses occurs within the NTS, probably at the first synapse of baroreceptor reflex fibres. Bilateral destruction of the NTS caused a ful-minating hypertension and tachycardia similar to that after cutting the baroreceptor afferent fibres. After both procedures, fentanyl (20 μg/kg i.v.) produced marked hypotension and bradycardia. The bradycardic effect was abolished by cutting both vagal nerves when the dogs were pretreated with a β-adrenoceptor blocking agent (S 2395, 50 μg/kg i.v.). The results provide evidence that the NTS is not the main site of action either for the hypotensive effect or for the vagally mediated bradycardia of fentanyl. Since the dorsal nucleus of the vagal nerve was destroyed together with the NTS, this nucleus does also not appear to be a major site of the action of fentanyl. Blockade of dopamine receptors by haloperidol or pimozide or of serotonin receptors by methysergide did not change the hypotensive, bradycardic and sympathoinhibitory effects of fentanyl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498691
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  • 3
    Electronic Resource
    Electronic Resource
    Partial transtentorial displacement of the cerebellum and the brain stem in hydrocephalus — A primary condition or a result of treatment? (1976)
    Springer
    Acta neurochirurgica 33 (1976), S. 151-165 
    Details
    ISSN: 0942-0940
    Keywords: brain stem, cerebellum ; transtentorial displacement ; hydro-cephalus communicans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two oases of upward displacement of parts of the brain stem and the cerebellum are discussed. In both cases shunts for a hydrocephalus had been operating for a long time (three and a half years in one and seven months in the other). One infant had a meningomyelocele but no complete Arnold-Chiari malformation. The cause of the hydrocephalus in the other case was doubtful, but was thought to be transtentorial displacement of the brain stem and the cerebellum causing traction on the pons and consequent meningeal fibrosis with obstruction of the cisterna pontis. In this case osseous hypoplasia of the posterior fossa was excluded by craniometry, so the upward displacement must have been due to hypoplasia of the tentorium cerebelli and its low attachment to the occiput, bringing about a narrowing of the infratentorial space. The authors believe the condition to be a primary malformation, and reject the hypothesis of secondary herniation following long standing supratentorial decompression. The concept of a primary malformation is supported by previous descriptions of the condition in cases with spina bifida, Arnold-Chiari malformation, and hydrocephalus without shunting, as well as by other features in the cases which have been recorded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01886666
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of clonidine on sleep patterns in man (1977)
    Springer
    European journal of clinical pharmacology 12 (1977), S. 319-322 
    Details
    ISSN: 1432-1041
    Keywords: Clonidine ; Yohimbine ; sleep ; REM sleep
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Clonidine (300 µg orally) increased in man the total duration of sleep and strikingly reduced the duration of REM sleep. Yohimbine (10 mg per os) did not alter the sleep patterns in man but antagonized the effects of clonidine. These results provide evidence that an α sympathomimetic mechanism could suppress REM sleep and increased the total duration of sleep.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562444
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  • 5
    Electronic Resource
    Electronic Resource
    Das Verhalten intraoperativ entstandener tiefer Venenthrombosen, beurteilt anhand wiederholter Phlebographien (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 521-526 
    Details
    ISSN: 1432-1440
    Keywords: Deep vein thrombosis ; phlebography ; postoperative ; fibrinogen test ; postthrombotic syndrom ; Tiefe Venenthrombose ; Phlebographie ; postoperativ ; Fibrinogentest ; postthrombotisches Syndrom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Rahmen einer prospektiven, randomisierten und kontrollierten Studie, in der die Thromboseprophylaxe-Mittel Dextran und Heparin bei allgemein-chirurgischen und urologischen Patienten geprüft werden, phlebographierten wir 31 Patienten mit sicherer tiefer Venenthrombose sofort nach der Diagnosestellung mittels125J-Fibrinogentest. 16 Patienten wurden 14 Tage später ein zweites Mal phlebographiert.Alle Thromben entstanden intraoperativ. 24 von 31 Patienten zeigten einemultifokale Entstehung der Thromben. Unabhängig vom Prophylaxe-Mittel und der eingeleiteten Therapie machten die Thromben in den ersten 14 Tagen nach deren Entstehung folgende Veränderungen durch: 9 retrahierten sich, 6 verschwanden, ohne Wandveränderungen aufzuweisen, und 1 verschloß das befallene Gefäß noch vollständig. 2 Thromben verschwanden ohne jegliche Therapie; 4 weitere unter Heparin- und/oder Phenprocoumonbehandlung.
    Notes: Summary Phlebography was carried out in a prospective randomised, controlled study during which dextran and small doses of s.c. heparin have been compared in general surgical and urological patients, in 31 persons with proven deep vein thrombosis diagnosed with the125I-fibrinogen test. In 16 out of the 31 patients a second phlebogram could be performed two weeks later. In this study all thrombi occurred intraoperatively. In 24 of the 31 patients, the appearance of thrombi was multilocular. Independent of the prevention instituted and irrespective of the therapy, the following phenomena could be seen 14 days after the first phlebogram: 9 thrombi retracted, 6 disappeared completely and 1 occluded the vein completely. 2 thrombi disappeared without any therapy whatsoever, the 4 others disappeared in patients receiving heparin and/or coumarin for treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468973
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  • 6
    Electronic Resource
    Electronic Resource
    Splitting of target fibers: Myopathic signs in denervation phenomena (1977)
    Springer
    Journal of neurology 214 (1977), S. 159-162 
    Details
    ISSN: 1432-1459
    Keywords: Voluntary muscle ; Denervation atrophy ; Myopathy ; Target fibers ; Fiber splitting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Faserspaltungsphänomene an Targetfasern in einem Fall von neurogener Muskelatrophie der Beine mit ausgeprägter Begleitmyopathie werden beschrieben und diskutiert. Erstmals wird das typisch myopathische Phänomen der Faserspaltung an für die neurogene Muskelatrophie als typisch erachteten Targetfasern dargestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02430353
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  • 7
    Electronic Resource
    Electronic Resource
    Multiple Frakturen des Atlas mit zweizeitiger tödlicher Vertebralisthrombose nach Schleudertrauma der Halswirbelsäule (1977)
    Springer
    Archives of orthopaedic and trauma surgery 87 (1977), S. 235-244 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über einen 62 Jahre alt gewordenen Mann berichtet, der auf dem Heimweg von der Arbeit in seinem PKW bei etwa 70 km/h einen Frontalzusammenstoß mit anschließendem Überschlagen erlitt. Da der Betroffene angeschnallt war und das Fahrzeug nach dem Überschlag wieder auf den Rädern zu stehen kam, war es nicht zu einem Anschlag des Kopfes gekommen, wie das Fehlen von Kopfverletzungen zeigte. Nach kurzer Bewußtlosigkeit bot der Patient keine neurologische Symptomatik; es bestanden lediglich Nackenschmerzen bei ausgeprägtem linksseitigem Nackenhämatom. Eine Berstungsfraktur des Atlasringes (Jefferson-Fraktur) mit Trümmerfraktur der linken Massa lateralis wurde in Standardröntgenaufnahmen nicht erkannt. Nach achttägigem „Wohlbefinden“ verstarb der Patient plötzlich und unerwartet. Bei der Sektion fand sich eine frische Thrombose der linken Arteria vertebralis, wobei mikroskopisch multiple dissezierende Wandverletzungen mit intramuralen Blutungen zu erkennen waren.
    Notes: Summary Report of the case of a 62 year old male, who died in a car crash on his way home from duty, when he had a frontal collison with annother car at a speed of about 70 km per hour. After the collision, the car had completely turned over to its wheels. As the man had put on the seat belts, he had not been cast against the front window so that there were no head injuries. Following an unconsciousness of about ten minutes the patient recovered quickly and was already fully oriented when arrived at hospital. No neurological symptoms could be substantiated. He only suffered from pain of the neck and had a marked swelling of the left side of the neck. A bursting fracture of the atlas vertebra (Jefferson-fracture) was overlooked in routine X-rays of the craniovertebral region. Eight days after the accident, the hitherto “well improving” patient died suddenly and unexpectedly. The autopsy revealed an obstructing thrombosis of the left vertebral artery, less than 24 hours old. The wall of the artery showed numerous dissecting ruptures with intramural bleedings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00415211
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