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  • 1
    ISSN: 1432-1017
    Keywords: Fluorescence polarization degree ; Fusion ; Label migration ; Lipid migration ; Cell membrane ; Virus envelope
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract The fluorescence depolarization of 1,6-diphenyl-hexatriene was used to study the dynamic properties of the hydrophobic regions of the lipid envelopes of ortho- and paramyxoviruses as well as of the Rous sarcoma virus and of the membrane lipids of susceptible and nonsusceptible cells. The systems investigated where active and inactive influenza viruses, and NDV virus acting on chick embryo fibroblasts and Rous sarcoma virus acting on susceptible (C/E) and nonsusceptible (C/B) chicken-cell. Polarization degrees and mean rotational correlation times of DPH embedded in viral lipids were significantly higher than those of DPH in the cell membranes, due to a higher rigidity of the virus envelopes. When suspensions of labelled viruses and unlabelled cells or unlabelled viruses and labelled cells were mixed, a characteristic change of the fluorescence polarization degrees with time was observed. This behaviour was ascribed to a label transfer from virus to cell membranes or vice versa. While the rate constants of label transfer from virus to cells and cells to virus were about the same for the penetrating viruses the rate constants of label release from inactive virus to cells were much larger than for the migration in the opposite direction.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 18 (1979), S. 0 
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1912
    Keywords: Rabbit caudate nucleus ; Dopaminergic neurones ; Presynaptic receptors ; Dopamine ; Nomifensine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Slices of the head of the rabbit caudate nucleus were preincubated with 10−7 M 3H-dopamine and then superfused, and the effect of unlabeled dopamine on the outflow of tritium was investigated. In most experiments, nomifensine was added throughout superfusion in order to block uptake of the unlabeled amine. Nomifensine was a potent inhibitor of the uptake of 3H-dopamine into rabbit caudate synaptosomes, with an IC50 of 5·10−8 M at a 3H-dopamine concentration of 4·10−8 M. In the absence of nomifensine, unlabeled dopamine (10−7 M and higher concentrations) accelerated the basal outflow of tritium from preincubated slices. 10−5 M nomifensine strongly counteracted the acceleration. In the presence of nomifensine, unlabeled dopamine (10−7 to 10−6 M) caused a concentrationdependent decrease of the overflow of tritium evoked by electrical stimulation at 0.1 Hz. Chlorpromazine and haloperidol (in the presence of nomifensine) increased the stimulation evoked overflow and antagonized the inhibitory effect of dopamine. It is concluded that extracellular dopamine shares with other dopaminergic agonists the ability to inhibit action potential-evoked release of intraneuronal dopamine. The inhibition is mediated by specific receptors. The results support the hypothesis that previously released dopamine, by an action on these receptors, can inhibit further release of dopamine.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European biophysics journal 5 (1979), S. 25-32 
    ISSN: 1432-1017
    Keywords: DPH-migration ; Virus adsorption ; Virus penetration ; Cells membranes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract A kinetic model was constructed and partly solved to describe the migration of the fluorescence label 1,6-diphenylhexatriene (DPH) in both directions when enveloped viruses, labelled with DPH in their envelopes are in contact with unlabelled cells or cell labelled in their membranes are in contact with unlabelled enveloped viruses. The central assumption is that two types of receptor sites exist on the cell surface, i.e., physical adsorption sites (P-sites), available to all the viruses studied in these papers and binding sites (B-sites) available only to the viruses which penetrate into the specific cells. The differential equations for the label migration, for different values of the ratio number of viruses number of sites were numerically solved, assuming different fractions of P- and B-sites. The equations also describe, appropriately the mechanism of rapid label migration in the system and substantiate the magnitude “time of residence” of the nonpenetrating viruses adsorbed on the cell surface. The resulting curves match satisfactorily those for the label release by the viruses and account well for the steady state values of the kinetics of label migration in the virus-cell system.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of thermal analysis and calorimetry 16 (1979), S. 285-290 
    ISSN: 1572-8943
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Résumé Dans le groupe des alliages durs contenant des borures et des siliciures, ceux à base cuivre ont présenté depuis ces dernièrs temps un intérêt croissant comme matériaux de revêtement résistant à l'usure et comme matériaux d'assemblage aux températures élevées. Afin d'établir les principes du développement optimal de ces alliages, on a mis au point les relations entre phases dans les systèmes nickel-cuivre-bore et nickel-cuivre-silicium sur des coupes isothermes à 700° et montré que la fusion se produit dans le domaine des faibles teneurs en métalloïdes, ce qui est important du point de vue des applications. Les alliages du domaine cristaux mixtes (Ni-Cu-B)-Ni3B ainsi que les coupes température-concentration Ni-Cu-10 At. % B et Ni-Cu-10 At. % Si ont servi d'exemples.
    Abstract: Zusammenfassung Innerhalb der Gruppe der borid- und silicidhaltigen Hartlegierungen finden solche auf Kupferbasis in jüngster Zeit zunehmend Interesse als verschleißfeste Beschichtungswerkstoffe und Hochtemperaturfügewerkstoffe. Als Grundlage für eine optimale Legierungsentwicklung wurden die Phasen Verhältnisse in den Systemen Nickel-Kupfer-Bor und Nickel-Kupfer-Silicium in isothermen Schnitten bei 700° geklärt und das anwendungs-technisch wichtige Schmelzverhalten im Bereich niedriger Metalloidgehalte am Beispiel von Legierungen des Gebietes (Ni-Cu-B)Mischkristall-Ni3B sowie der Temperatur-Konzentrationsschnitte Ni-Cu-10 At.-% B und Ni-Cu-10 At.-% Si aufgezeigt.
    Notes: Abstract Within the group of boride and suicide containing hard alloys, those based on copper have recently found increasing interest as wear-resisting stratification and high-temperature structural materials. For the development of the best alloy, the phase conditions in the systems nickel-copper-boron and nickel-copper-silicon were elucidated from the isothermal profiles at 700°. Melting behaviours (important from a practical point of view) in the area of low metalloid contents are presented in the cases of (Ni-Cu-B) mixed crystals, Ni3B alloy, as well as Ni-Cu-10 atomic % B and Ni-Cu-10 atomic % Si.
    Type of Medium: Electronic Resource
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