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  • 1
    Electronic Resource
    Electronic Resource
    A search for internal distortion in CeBi (1980)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 13 (1980), S. 529-532 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: At the IA magnetic transition (12.5 K) in CeBi a theoretical study has suggested that either the Ce or Bi sublattices should move with respect to the other. Such a distortion would give rise to extra reflections of the form 0′0′l+½. A search for such a reflection using a Bond X-ray diffraction technique was conducted. The 007½ line was not found and an upper limit of 2̃ × 10−4 was set for the magnitude of the expected internal distortion. This limit is valid for a surface layer whose thickness equals the penetration depth of the X-radiation which is about 0.4 × 10−2 mm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889880012721
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  • 2
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1980)
    Springer
    Monatshefte für Mathematik 89 (1980), S. 77-86 
    Details
    ISSN: 1436-5081
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01571567
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  • 3
    Electronic Resource
    Electronic Resource
    Adenine and hypoxanthine metabolism in phythohemagglutinin-stimulated and unstimulated human lymphocytes (1980)
    Springer
    Annals of hematology 40 (1980), S. 137-145 
    Details
    ISSN: 1432-0584
    Keywords: Blutlymphozyten ; Adeninstoffwechsel ; Hypoxanthinstoffwechsel ; Phytohaemagglutinin ; Blood lymphocytes ; Adenine metabolism ; Hypoxanthine metabolism ; Phytohemagglutinin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The uptake and subsequent metabolism of adenine and hypoxanthine in phytohemagglutinin-stimulated and unstimulated peripheral human blood lymphocytes, freshly prepared or cultured, were studied. To investigate the initial step of nucleic acid metabolism the incorporation of14C-purines into the acid soluble material was examined. No preferential uptake of adenine or hypoxanthine was observed in freshly prepared and cultured lymphocytes during an incubation of 1 h. However, cultured cells utilized approximately 1/3 of the purines compared to freshly drawn cells. Within the cells 2/3 of adenine and 1/2 of hypoxanthine were metabolized to nucleotides (mainly AMP and ADP). Incubation of lymphocytes with PHA for 1 h produced in the freshly prepared cells an increase of adenine- and hypoxanthine-uptake to 191% and 153%, in 48 h stimulated cells to 158% and 132%. There was, however, no change in the relative rates of the metabolic routes though the intracellular concentrations of nucleotides formed increased with adenine as substrate to 152% and with hypoxanthine to 161% during a 1 h stimulation. In contrast no enhanced formation of acid soluble nucleotide formation could be observed with PHA stimulation during 48 h. The increased rates of purine uptake and metabolism apparent 1 h after addition of mitogen may be due to an altered transport mechanism at the beginning of the transformation as an adaptive response to the increased requirements for the synthetic processes soon to follow. Once the lymphocytes are transformed no demand of purines is necessary and the uptake and metabolism is switched off.
    Notes: Zusammenfassung Die Aufnahme und der Stoffwechsel von Adenin und Hypoxanthin in Phytohaemagglutinin-stimulierten und unstimulierten Blutlymphozyten wurden untersucht. Durch den Einbau von14C-markierten Purinen in die säurelösliche Fraktion sollte der 1. Schritt des Nukleinsäurestoffwechsels gemessen werden. Zwischen frisch präparierten und 48 h kultivierten Lymphozyten konnte keine bevorzugte Aufnahme von Adenin bzw. Hypoxanthin festgestellt werden. Die kultivierten Zellen metabolisierten jedoch im Vergleich zu den frisch gewonnenen Lymphozyten nur etwa 1/3 der Purine. Intrazellulär wurde 2/3 des Adenins und die Hälfte des Hypoxanthins hauptsächlich zu den Nukleotiden AMP und ADP metabolisiert. Eine 1stündige Inkubation mit PHA führte in den frischen Lymphozyten zu einem Anstieg der Adenin-bzw. Hypoxanthinaufnahme auf 191% bzw. 153% verglichen mit den Ausgangswerten. Hingegen stiegen die entsprechenden Werte während einer PHA-Stimulation von 48 h auf 158% bzw. 132% an. Obwohl die intrazelluläre Bildung der Nukleotide aus Adenin bzw. Hypoxanthin nach 1 h PHA-Stimulation auf 152% bzw. 161% anstieg, kam es zu keiner Änderung der relativen Durchflußraten der verschiedenen Stoffwechselwege. Im Gegensatz war nach 48 h Stimulation keine vermehrte Nukleotidbildung nachweisbar. Sowohl die gesteigerte Aufnahme als auch die erhöhte Nukleotidbildung nach 1 h PHA-Stimulation könnte auf geänderte Transporteigenschaften der Lymphozytenmembran hinweisen und die erste Antwort der Zelle auf den mitogenen Reiz darstellen. Dadurch könnte der gesteigerte Bedarf an niedermolekularen Substanzen für die nachfolgenden Biosynthesen gedeckt werden. Nach abgeschlossener Transformation würde kein vermehrter Bedarf bestehen und somit die Aufnahme und Metabolisierung gedrosselt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01013696
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  • 4
    Electronic Resource
    Electronic Resource
    Angiotensin Converting Enzyme (ACE) Ein in vitro-Test für die Sarkoidose-Diagnostik (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 195-198 
    Details
    ISSN: 1432-1440
    Keywords: Angiotensin converting enzyme ; Sarcoidosis ; Granulomatous diseases ; Clinical diagnosis ; Angiotensin-Converting Enzyme ; Sarkoidose ; Granulomatosen ; klinische Diagnostik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 50 Patienten mit Sarkoidose (39 mit aktiver, 11 mit inaktiver Sarkoidose) wurde das Angiotensin-converting enzyme (ACE) im Serum bestimmt. Die Gruppe der Kontrollpatienten umfaßte 50 Personen (34 mit chronischen Lungenerkrankungen, 9 mit Morbus Hodgkin, 7 mit chronischer Polyarthritis). Der Unterschied der Mittelwerte der ACE-Aktivität war zwischen Sarkoidosepatienten (28,6±11,4) und Kontrollpatienten (14,8±4) hochsignifikant (p〈0,001). Ebenso fand sich ein deutlicher Unterschied zwischen Patienten mit aktiver (32,8±11) und inaktiver Sarkoidose (21,9±5,1) mit einemp〈0,001. Corticosteroide senken die ACE-Aktivität bei Sarkoidosepatienten deutlich, ohne daß dies als Hinweis für eine Besserung der Sarkoidose gewertet werden kann. Die gesteigerte ACE-Aktivität bei anderen epitheloidzelligen Granulomatosen (biliäre Zirrhose, Morbus Gaucher, Lepra, Asbestose) repräsentiert möglicherweise einen mit der Sarkoidose gemeinsamen pathophysiologischen Mechanismus.
    Notes: Summary Serum angiotensin-converting enzyme (ACE) was studied in 50 patients with sarcoidosis (39 active, 11 inactive) as well as in 50 control patients (34 with chronic nonspecific lung disease, 9 with Hodgkin and 7 with rheumatoid arthritis). There was a significant difference of ACE activity between sarcoidosis patients (28.6±11.4) and controls (14.8±4), and also between active (32.8±11) and inactive (21.9±5.1) sarcoidosis (p〈0.001). Coricosteroid treatment seems to lower ACE activity in patients with sarcoidosis without offering a clue for clinical improvement. Increased ACE activity in other granulomatous disorders is being discussed. ACE activity thus proves to be a valuable test especially in differentiating active from inactive sarcoidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476778
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  • 5
    Electronic Resource
    Electronic Resource
    Glycosylated haemoglobin in renal failure (1980)
    Springer
    Diabetologia 19 (1980), S. 555-556 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253184
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  • 6
    Electronic Resource
    Electronic Resource
    Structural properties of fibrinogen and intermediate fibrins (1980)
    Springer
    European biophysics journal 6 (1980), S. 48-48 
    Details
    ISSN: 1432-1017
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00647521
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  • 7
    Electronic Resource
    Electronic Resource
    The induced interfacial hydration: Model experiments concerning water structure near biological interfaces (1980)
    Springer
    European biophysics journal 6 (1980), S. 52-52 
    Details
    ISSN: 1432-1017
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00647525
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  • 8
    Electronic Resource
    Electronic Resource
    Purine metabolism of erythrocytes in myotonic dystrophy (1980)
    Springer
    Journal of neurology 223 (1980), S. 59-66 
    Details
    ISSN: 1432-1459
    Keywords: Myotonic dystrophy ; Erythrocytes ; Adenine and adenosine uptake ; Adenine nucleotide formation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Aufnahme und der Stoffwechsel von Adenin und Adenosin in Erythrocyten von Patienten mit myotoner Dystrophie (MD) wurde untersucht. Zur Charakterisierung des Aufnahmevorganges wurden gewaschene Erythrocyten von Kontrollpersonen bzw. Patienten mit 14C-markiertem Adenin oder Adenosin bei 20° C für 5 bis 120s inkubiert. Zwischen den Kontrollen und den Patienten waren keine Unterschiede nachweisbar. Nach 30 min Inkubation bei 37° C wurden die gebildeten Adeninnukleotide bestimmt. Im Vergleich zu den Kontroll-Erythrocyten wurde in den Erythrocyten der MD-Patienten Adenin um den Faktor 2.6 vermehrt in Adeninnukleotide eingebaut, wobei es zu einem Anstieg des Quotienten aus ATP: ADP+AMP von durchschnittlich 0,92 auf 1,39 kam. Adenosin wurde hingegen in den Erythrocyten beider Kollektive in gleicher Weise metabolisiert. Die Ergebnisse weisen auf keine Störung der Purintransportsysteme an Erythrocyten von MD-Patienten, lassen aber trotz normaler intraerythrocytärer ATP-Konzentration auf einen größeren Bedarf an ATP schließen, der auf einen vermehrten Austritt der Adeninnukeotide aus dem MD-Erythrocyten zurückzuführen sein könnte.
    Notes: Summary The uptake and subsequent metabolism of adenine and adenosine was studied with the intact erythrocytes of patients with myotonic dystrophy (MD). Washed erythrocytes of both controls and patients were incubated with 14C-labeled adenine or adenosine at 20°C for 5 to 120s to characterize the uptake process. No differences in the uptake process of adenine or adenosine were observed between normal and MD erythrocytes. Formation of adenine nucleotides was determined at 37° C after incubation for 30 min. Compared to controls, the incorporation of adenine into adenine nucleotides was 2.6 times higher in MD erythrocytes. This depends mainly on an increase of ATP formation. The mean ratios of ATP: ADP+AMP for normal red cells and MD erythrocytes were 0.92 and 1.39 respectively. No difference was found in the conversion of adenosine to adenine nucleotides. In spite of a normal amount of intracellular ATP a greater demand for ATP exists. This might be due to leakage of adenine nucleotides out of MD erythrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313140
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  • 9
    Electronic Resource
    Electronic Resource
    In vivo glucose turnover in hypo- and hyperthyroid starved rat (1980)
    Springer
    Pflügers Archiv 386 (1980), S. 47-52 
    Details
    ISSN: 1432-2013
    Keywords: 3H-(2)-glucose ; 14C-(U)-glucose ; Glucose turnover ; Glucose recycling ; Thyroid state
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of hypo- and hyperthyroidism on glucose turnover in vivo was determined in unanesthetized rats starved for 48 h. Glucose pool and decay rate of specific radioactivity of blood glucose was measured after bolus injection of a mixture of3H-(2)- and14C-(U)-glucose under steady state conditions. Compared with euthyroid controls (=100%), hypothyroidism resulted in a decrease of blood glucose concentration (81%), glucose pool (52%), glucose disappearance rate (39%), and total glucose recycling (12%). In contrast, hyperthyroidism led to an increase of blood glucose concentration (148%), glucose pool (121%), glucose disappearance rate (185%), and and total glucose recycling (163%).T 1/2 for glucose was calculated to be 46 min in the hypo-, 34 min in the eu-, and 22 min in the hyperthyroid state. The concentration of circulating glucoregulatory hormones, corticosterone and glucagon were elevated in hyperthyroid rats, while glucagon was diminished in hypothyroid animals. No difference in the level of insulin was found. These data demonstrate that glucose turnover in vivo is a function of the thyroid state being reduced in hypo- and considerably increased in hyperthyroidism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584186
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  • 10
    Electronic Resource
    Electronic Resource
    322. Klinische und experimentelle Untersuchungen an Venenkanülen (1980)
    Springer
    Langenbeck's archives of surgery 352 (1980), S. 618-618 
    Details
    ISSN: 1435-2451
    Keywords: Randomized trial ; Venous cannulac ; Puncture characteristics ; Manufacturing quality ; Prospektive Studie ; Kunststoffverweilkanülen ; Punktionseigenschaften ; Gewebereaktion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 300 Patienten wurden prospektiv randomisiert 6 verschiedene Kunststoffverweilkanülen eingesetzt (Braunöle 1, Viggo, Abbocath, Intranüle, Quickcath, Jelco) (niederosmolare Lösungen). Die lokalen Auswirkungen der Punktion am Einstichort wurden graduell bei 24, 48, und 72 h mit Hilfe eines 6-PunkteSchemas protokolliert. Die Punktionseigenschaften der Kanülen maßen wir an Leichenhauteinstichversuchen. Die Thrombogenitität ermittelten wir durch Bestimmung des Thrombustrockengewichtes und des RFT-Testes bei Ratten. Es konnte gezeigt werden, daß eine enge Relation besteht zwischen Verarbeitung und Gewebsreaktion.
    Notes: Summary In a prospective randomized trial 300 patients received one of 6 different venous cannulae for a period of 1–3 days (Braunöle 1, Viggo, Abbocath, Intranüle, Quickcath, Jelco). Low molecular infusions were given under standardized conditions. We used a 6-point check list to classify local skin reactions. The puncture characteristics of the cannulae were investigated on fresh cadaver skin using the “Instron” testing device. In rat experiments we measured the rate of thrombogenicity of these cannulas by using the RFT-test and by determining the thrombus weights. We demonstrated a correlation between manufacturing quality of the cannulas and the rate of complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292287
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