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  • 2000-2004  (14)
  • 1990-1994
  • 1980-1984  (4)
  • 1970-1974
  • 1965-1969
  • 2000  (14)
  • 1983  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Compound heterozygous group A xeroderma pigmentosum patient with a novel mutation and an inherited reciprocal translocation (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The severity of neurological abnormalities in Japanese group A xeroderma pigmentosum (XP-A) patients correlates with the sites of non-sense mutation in the XP-A gene. We describe a patient who presented with a more severe photosensitivity and neurological abnormality than those in typical Japanese XP-A patients with a splicing mutation in intron 3. The patient was compound heterozygous for the splicing mutation in intron 3, which resulted in formation of a non-sense codon in exon 4, and a novel non-sense mutation at codon 208 in exon 5, a C to T transition creating a stop codon TAG. Although the combination of these mutations might have been thought to cause only mild neurological signs, the longer truncated XP-A proteins than those of typical XP-A patients may have resulted in severe neurological symptoms. This phenomenon may be explained by a translocation of chromosome (1;10)(q25·3;q22·3) inherited from his father.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03611.x
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  • 2
    Electronic Resource
    Electronic Resource
    Reduction of interface-state density in 4H–SiC n-type metal–oxide–semiconductor structures using high-temperature hydrogen annealing (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 76 (2000), S. 1585-1587 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effects of hydrogen annealing on capacitance–voltage (C–V) characteristics and interface-state density (Dit) of 4H–SiC metal–oxide–semiconductor (MOS) structures have been investigated. The Dit was reduced to as low as 1×1011 eV−1 cm−2 at Ec−E=0.6 eV using hydrogen annealing above 800 °C, where Ec−E is the energy level from the conduction-band edge. Secondary ion mass spectroscopy and Dit analysis revealed that Dit decreased with the increase of hydrogen concentration accumulated at the SiO2/4H–SiC interface. The interface states at SiO2/4H–SiC are thought to be originated from the dangling bonds of C atoms as well as Si atoms, because Dit decreases as the hydrogen annealing temperature increases and saturates around 800 °C. This high-temperature hydrogen annealing is useful for accumulation-type SiC metal–oxide–semiconductor field-effect transistors, which have n-type MOS structures to reduce the Dit. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.126103
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Masticatory movement in two cases with unusual alignment of the maxillary canine (2000)
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 27 (2000), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Masticatory function was analysed before and after orthodontic treatment in two cases where tooth alignment remained unusual after treatment. The Sirognathograph Analyzing System® was used to analyse the masticatory function. In both cases, the right maxillary first premolar was located where the maxillary canine is normally positioned. The results of orthodontic treatment were satisfactory both morphologically and aesthetically, and masticatory function was greatly improved. However, some problems remained in the mandibular movement due to the abnormal contact between the mandibular teeth and the maxillary first premolar. These findings support the need for examination of masticatory function when treating patients with an unusual tooth alignment even if the results of orthodontic treatment are both morphologically and aesthetically successful.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2842.2000.00565.x
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  • 4
    Electronic Resource
    Electronic Resource
    The role of tumor necrosis factor-α in diffuse axonal injury following fluid-percussive brain injury in rats (2000)
    Springer
    International journal of legal medicine 113 (2000), S. 221-228 
    Details
    ISSN: 1437-1596
    Keywords: Key words Traumatic head injury ; Diffuse axonal ¶injury ; Tumor necrosis factor-α ; β-Amyloid precursor ¶protein ; Fluid percussion device ; Glial cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract The immunolocalization of tumor necrosis factor-α (TNFα) after diffuse axonal injury (DAI) is demonstrated using a midline fluid percussion rat model (moderate brain injury of 1000 mm Hg was generated) and the effects of TNFα on the axolemmal permeability using horseradish peroxidase as a tracer. In addition, the accumulation of β-amyloid precursor protein (β-APP) was investigated, which has recently been shown to be a reliable marker for the diagnosis of DAI in cases with fatal head injury. TNFα levels in brain tissues from the impact site and the cortex including the corpus callosum, gradually increased during the first 1 h, rose to a maximal elevation at 3 h, gradually decreased at 6 h and decreased further at 24 h. Horseradish peroxidase (HRP) tracer experiments revealed that primary axonal damage appeared as early as 15 min after impact but rapidly recovered and that 1 h after impact, secondary axonal damage occurred in the corpus callosum and the brain stem. By immunoelectron microscopy it was seen that β-APP accumulated in the axon from 1 h after impact demonstrating that there was functional axonal damage. TNFα reactions were detected in the lysosomes of microglia 30 min after impact and 1 h after impact these reactions were mainly detected in the glial cells (such as microglia, astrocytes and oligodendrocytes) in the corpus callosum and the brain stem. It is generally accepted that TNFα directly induces primary demyelination and oligodendrocyte apoptosis. Therefore, TNFα conveyed from the microglial cells is one cofactor contributing to the formation of the delayed axonal damage observed at these sites. The present study suggests that TNFα conveyed from the glial cells may contribute to the pathogenic mechanism of DAI formation following fluid percussive brain injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004149900095
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  • 5
    Electronic Resource
    Electronic Resource
    New approach of semiconductor laser related technologies for ultrafast photonics (2000)
    Springer
    Optical and quantum electronics 32 (2000), S. 443-452 
    Details
    ISSN: 1572-817X
    Keywords: semiconductor laser ; ultrafast photonics ; ultrashort optical pulse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract Ultrashort laser pulses offer new jump in information and communication technology. Especially semiconductor laser based ultrafast photonic devices and systems are promising. We review our new approaches for femtosecond pulse generation, and thin film technology for broad band semiconductor optical amplifiers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007061222228
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  • 6
    Electronic Resource
    Electronic Resource
    Subcellular distribution and binding of heavy metals in the untreated liver of the squid; comparison with data from the livers of cadmium and silver-exposed rats (1983)
    Springer
    Cellular and molecular life sciences 39 (1983), S. 746-748 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In natural squid liver, about 30% of the total Cd present was found in the cytosolic fraction. A large portion of this Cd was bound to high molecular weight species (mol. wt〉70,000). In contrast to Cd, about 60% of the total Ag occurred in the cytosolic fraction; Ag was bound mainly to low molecular weight species (mol. wt〈20,000).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01990305
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  • 7
    Electronic Resource
    Electronic Resource
    Development of a Robotic System which Assists Unmanned Production Based on Cooperation between Off-Line Robots and On-line Robots. Part 3. 1 Development of an Off-Line Robot, Autonomous Navigation, and Detection of Faulty Workpieces in a Vibrating Parts Feeder (2000)
    Springer
    The international journal of advanced manufacturing technology 16 (2000), S. 582-590 
    Details
    ISSN: 1433-3015
    Keywords: Keywords:Fault recovery; Navigation; Off-line robot; Pilot plant; Stereo-vision; Trouble simulator; Unmanned production; Vision-based search
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Remarkable advances in robotics and intelligent technology have made unmanned production realisable. Based on the off-line robot concept proposed in our first paper, an off-line robot and peripheral devices have been developed for the realisation of unmanned production. The developed robot has a power-wheeled steering (PWS) type mobile platform on which a double-arm manipulator is installed. In order to detect and recognise 3D objects, double CCD cameras are mounted on the top of the robot. Two types of robot end-effectors are developed to handle workpieces and conduct trouble shooting actions. A newly developed production trouble simulator is very useful in simulating and resolving production troubles. A virtual pilot plant for production composed of the off-line robot, two on-line robots, a vibrating bowl feeder, a belt conveyor and a production trouble simulator has been constructed and tests for production simulation have been undertaken. In this paper, autonomous navigation of the developed robot in the virtual pilot plant is investigated. Then a search for faulty parts in a parts feeder using the developed real-time image extraction method is carried out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001700070048
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  • 8
    Electronic Resource
    Electronic Resource
    Pleomorphic intra-neuronal polyglucosan bodies mainly restricted to the pallidium (1983)
    Springer
    Acta neuropathologica 62 (1983), S. 159-163 
    Details
    ISSN: 1432-0533
    Keywords: Pleomorphic polyglucosan body ; Bielschowsky body ; Lafora body ; Corpora amylacea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A rare case with pleomorphic intra-neuronal polyglucosan bodies is reported. A 45-year-old man died of gastric carcinoma with extensive visceral involvement. The autopsy showed numerous intra-neural pleomorphic PAs-positive deposits reminiscent of Bielschowsky bodies in the lateral segments of the pallidum, substantia nigra, and brain stem on both sides. Their histochemical properties were consistent with polyglucosan. The bodies were ultrastructurally composed of filamentous structures and seen in perikarya, axons, and dendrites. Occasionally, spotty electron-dense material was seen in the center of the bodies. The filaments were selectively stained with thiocarbohydrazide method after Thiéry, indicating their chief component as glucose polymers. The bodies are compared with Bielschowsky bodies, Lafora bodies, corpora amylacea, and related bodies, and their nature and significance are briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684936
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  • 9
    Electronic Resource
    Electronic Resource
    Three-dimensional comparative study of Merkel cell distribution in various body sites of guinea pigs and rats (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 173-179 
    Details
    ISSN: 1432-069X
    Keywords: Key words Merkel cells ; Hair cycle ; Hair follicles ; Bulge areas ; Guinea pigs ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The hair cycling pattern differs between humans and mice: for the former it is mosaic, while the latter show a wave pattern. We focused on the presence or absence of synchronization of the hair cycle based on the distribution of Merkel cells. The three-dimensional distribution and number of Merkel cells in the skin at various sites were determined in guinea pigs and rats. Using ethylenediaminetetraacetic acid, various types of hair follicles were obtained from the facial, abdominal, nipple, back, tail, perianal and plantar skin. Epidermal sheets containing numerous hair follicles were immunostained using monoclonal murine antibody CK20 which is generally accepted to be a specific immunocytochemical marker for Merkel cells of various species. Merkel cells were absent in the trunk skin of guinea pigs and rats, in complete contrast to the situation in humans. In vibrissa and other hair follicles within specialized sensitive areas, Merkel cells were found in varying numbers. Some differences in their distribution and number were observed between guinea pigs and rats. The absence of Merkel cells in the hair follicles of the trunk skin of rats and guinea pigs implies that Merkel cells are not essential for the induction and promotion of hair growth but have some different functional significance in hair follicles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050474
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  • 10
    Electronic Resource
    Electronic Resource
    Interleukin-1α enhances mast cell growth by a fibroblast-dependent mechanism (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 240-247 
    Details
    ISSN: 1432-069X
    Keywords: Key words Stem cell factor ; c-kit ; Cyclooxygenase ; Prostaglandin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mast cell hyperplasia is observed in various inflammatory skin diseases. Although the pathogenesis of these conditions remains largely uninvestigated, it has been speculated that lesional mediators provide a favorable microenvironment for mast cell growth. We investigated the effect of an inflammatory cytokine, IL-1α, on mast cell growth in a mast cell/fibroblast coculture system. When mouse bone marrow-derived cultured mast cells (BMMC) were cultured on a NIH/3T3 fibroblast monolayer, IL-1α stimulated mast cell proliferation. However, IL-1α did not stimulate 3H-thymidine incorporation in BMMC in the absence of fibroblasts. Separation of BMMC from fibroblasts by a permeable micropore membrane reduced the effect of IL-1α. When BMMC were prepared from W/W v mice, which lack a functional c-kit, or when NIH/3T3 fibroblasts were substituted with Sl/Sl d -derived fibroblasts, which lack membrane-bound stem cell factor (SCF), a lower, but significant, effect of IL-1α was observed. Flow cytometric analysis revealed no enhancement of SCF expression on fibroblasts following stimulation with IL-1α. Neutralizing antibodies against IL-3, IL-4, IL-10, and nerve growth factor (NGF) showed no inhibition. On the other hand, indomethacin inhibited the effect of IL-1α, and prostaglandin E2 induced mast cell growth in the cocultures. These results indicate that IL-1α stimulates mast cell growth by a fibroblast-dependent mechanism, in which SCF/c-kit interaction may participate in a major way. The mast cell growth activity induced by this cytokine can, at least in part, be attributed to prostaglandins. Inflammatory cytokines may thus contribute to mast cell hyperplasia in skin diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050481
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