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  • 1985-1989  (5)
  • 1930-1934
  • 1985  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Die Beeinflussung der Organperfusion durch Kalziumblocker und Converting-Enzyminhibitor an der herzinsuffizienten, wachen Ratte (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 262-267 
    Details
    ISSN: 1432-1440
    Keywords: Captopril ; Diltiazem ; Regional blood flow ; Experimental heart failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study examined the regional vascular effects (radioactive microspheres) of converting-enzyme inhibition (captopril, 1mg/kg) and calcium-antagonism (diltiazem, 1 mg/kg) in a rat model of cardiac failure due to large myocardial infarction (n=18, infarct size 40% of the left ventricle) both at rest and during submaximal tread-mill exercise. Diltiazem increased renal, gastrointestinal, coronary and cutaneous blood flow at rest by 29%, 28%, 26% and 37% (p〈0.05 each) and enhanced skeletal muscle blood flow during exercise by 16% (p〈0.05). Captopril improved primarily renal and coronary blood flow at rest (by 59% and 23%, respectively,p〈0.05) and reduced vascular resistance in the gastrointestinal bed by 25% (p〈0.05) without significant effects in other circulatory beds. We conclude that the regional vascular effects elicited by converting-enzyme inhibition and calcium antagonism differ considerably in this animal model of congestive heart failure and may be clinically important. The favourable regional vascular profile of diltiazem deserves further clinical investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731472
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Diagnostik kardiovaskulärer Erkrankungen mit Hilfe der suprasternalen M-mode Echokardiographie (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 193-204 
    Details
    ISSN: 1432-1440
    Keywords: Suprasternal M-mode echocardiography ; Cardiovascular diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The suprasternal approach can be used to image the aortic arch, the right pulmonary artery and the left atrium. Dilatation or dissections involving the aortic arch were detected echocardiographically from the suprasternal notch. The echocardiogram of the right pulmonary artery is altered in cases of acute and chronic pulmonary hypertension. Intrapulmonary thrombi in patients with acute pulmonary embolism were visualized with this technique. A volume overloading of the pulmonary circulation due to a congenital left to right shunt, as well as a decreased pulmonary blood flow due to a congenital right to left shunt causes characteristic changes in the wall motion pattern of the right pulmonary artery. Hypoplasia or aplasia of the central pulmonary arteries can be diagnosed as well. Imaging of the left atrium from the suprasternal notch may help to differentiate between supraventricular and ventricular rhythm disturbances. The suprasternal approach is therefore recommended to be used as a routine part of each echocardiographic examination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731169
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of carteolol in relation to renal function (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 461-465 
    Details
    ISSN: 1432-1041
    Keywords: carteolol ; chronic renal failure ; pharmacokinetics ; dosage adjustment ; metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma levels and urinary excretion of carteolol and its main metabolites 8-hydroxycarteolol and carteolol glucuronide were investigated in 6 healthy subjects and 9 patients with varying degrees of renal impairment following a single oral dose of 30 mg carteolol hydrochloride. In healthy subjects the half-life of carteolol was 7.1 h. 63% of the administered dose was recovered unchanged in urine, and in all 84% was excreted by the kidneys. The renal clearance of carteolol was 255 ml/min. In chronic renal failure (CRF) the terminal half-life was increased to a maximum of 41 h. Both the elimination rate constant and renal clearance were closely related to the creatinine clearance. In CRF the recovery of carteolol and its metabolites from urine was considerably reduced, suggesting that another pathway of drug elimination becomes relevant in renal disease. To avoid an increase in side-effects due to drug accumulation, the dosage of carteolol should be adjusted in relation to the reduction in creatinine clearance. The maintenance dose should be reduced to a half in patients with a creatinine clearance below 40 ml/min and above 10 ml/min. In those with a creatinine clearance of 10 ml/min or less, the dose should be reduced to 1/4.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613462
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Concentrations of mezlocillin in the serum, heart valves, muscle and subcutaneous tissue of patients undergoing open-heart surgery (1985)
    Springer
    Infection 13 (1985), S. 182-183 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Präoperativ erhielten 31 erwachsene Patienten innerhalb einer fünfminütigen intravenösen Gabe 4 g Mezlocillin vor einer Operation am offenen Herzen. Die Serumspiegel von Mezlocillin sanken von 42,8 mg/l 1–2 Stunden nach Gabe auf 〈 1 mg/l 6–8 Stunden nach Injektion. Mezlocillinkonzentrationen im Muskel und subkutanen Geweben zeigten eine Schwankung zwischen 18 µg/g und 〈 1 µg/g. Die Mezlocillin-Spiegel waren in den Herzklappen höher als jene im Muskel und subkutanen Gewebe. Dieses Ergebnis läßt auf eine schnelle Diffusion von Mezlocillin schließen, sogar bei vernarbten Herzklappen.
    Notes: Summary 4 g mezlocillin as a five-minute intravenous bolus were given preoperatively to 31 adult patients undergoing open-heart surgery. Mezlocillin serum levels declined from 42.8 mg/l at 1–2 h after injection to 〈 1 mg/l at 6–8 h after application. Concentrations in muscle and subcutaneous tissue varied between 18 µg/g and 〈 1 µg/g. Mezlocillin levels in heart valves were higher than those in muscle and subcutaneous tissue, thus suggesting rapid diffusion of mezlocillin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01642809
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    In vitro activity of five quinoline derivatives against nosocomial isolates ofStaphylococcus andPseudomonas species (1985)
    Springer
    European journal of clinical microbiology & infectious diseases 4 (1985), S. 72-73 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02148670
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    Paper (German National Licenses)
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