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  • 1
    Electronic Resource
    Electronic Resource
    Relaxation of radiation damage in silicon planar detectors (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 76 (1994), S. 4072-4076 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The behavior of radiation-induced carbon-related defects in high-resistivity silicon detectors has been investigated. The defects were introduced by α-particle irradiation and investigated by deep-level transient spectroscopy. An unusual defect behavior consists in low-temperature annealing, including self-annealing at room temperature, of the interstitial carbon Ci with a simultaneous increase of the Ci-Oi-complex concentration. The kinetic parameters of the process have been determined from the increase of the Ci-center concentration versus time. Two annealing velocities have been observed, which arise from different heat treatments during the detector fabrication process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.357356
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  • 2
    Electronic Resource
    Electronic Resource
    Low antithrombin III in neonatal shock: DIC or non-specific protein depletion? (1986)
    Springer
    European journal of pediatrics 145 (1986), S. 500-503 
    Details
    ISSN: 1432-1076
    Keywords: Antithrombin III ; Albumin ; Shock
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Low antithrombin III (AT III) levels in shock are usually ascribed to disseminated intravascular coagulation (DIC). However, decreased activities of clotting factors and their inhibitors could reflect a generalised fall in plasma proteins rather than DIC. AT III and albumin were compared in 48 asphyxiated and non-asphyxiated newborn rabbits (pH6.70–7.30). Both AT III and albumin were markedly decreased in the sickest animals and there was a direct linear relationship between the two proteins (P〈0.001). Similar results were obtained in ten newborn infants suffering from shock and haemorrhagic diathesis. In all cases AT III and albumin were decreased below the normal range and significantly correlated (P〈0.01). Our findings suggest that AT III is not a useful diagnostic marker of DIC. Further, a similar fall of clottable and non-clottable proteins in shock questions the general assumption that the ensuing coagulopathy is due to intravascular coagulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02429051
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  • 3
    Electronic Resource
    Electronic Resource
    Afterhyperpolarization modulation in lumbar motoneurons during locomotor-like rhythmic activity in the neonatal rat spinal cord in vitro (1994)
    Springer
    Experimental brain research 99 (1994), S. 214-222 
    Details
    ISSN: 1432-1106
    Keywords: Afterhyperpolarization ; Motoneuron ; Locomotion ; In vitro ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Motoneuron afterhyperpolarization (AHP) amplitude and somatic input conductance were monitored during pharmacologically induced, locomotorlike ventral root activity using an isolated neonatal rat spinal cord preparation (transected at the C1 level). Nonspontaneously firing motoneurons were selected for study. Single spikes were evoked at regular intervals by brief depolarizing current pulse injections, while somatic input conductance was monitored by hyperpolarizing current pulses. The induction of rhythmic ventral root activity was associated with tonic depolarization of motoneurons as well as superimposed rhythmically alternating membrane depolarization and hyperpolarization (locomotor drive potentials, LDPs). In 9 of 13 trials (six of eight cells) the peak amplitude of AHPs following current-evoked action potentials was reduced during both the hyperpolarized and the depolarized phases of the LDP, compared with the pre-locomotor condition. The peak AHP amplitude increased during the depolarized phase of the LDP in 4 of 13 trials (three of eight cells); however, in 3 of these 4 trials measurement of the AHP later in the course of its trajectory, using a half decay time (HDt) reference point, demonstrated AHP amplitude reduction during rhythmic activity compared with the prelocomotor condition. In seven of eight motoneurons the induction of rhythmic activity was associated with a decrease in input conductance. The pattern of AHP amplitude and conductance modulation during the two phases of the LDP was consistent for individual trials; however, there was considerable intertrial variation. The results suggest that AHP modulation during locomotor-like activity in this preparation can be mediated independently of supraspinal influences by intrinsic spinal cord mechanisms, and the observed AHP suppression does not appear to be the passive result of an increase in background conductance. The discrepancy between peak and HDt-based AHP amplitude measurements during the depolarized phase of the LDP in some trials may be due to competing effects of passively enhanced potassium currents and a mechanism that actively reduces the calcium-dependent potassium conductance. The possibility that both the AHP amplitude and the input conductance changes observed during locomotor-like activity reflect a regulation of potassium channels is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239588
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  • 4
    Electronic Resource
    Electronic Resource
    Spezifische IgM-Teste in der Syphilis-Diagnose (1994)
    Springer
    Der Hautarzt 45 (1994), S. 685-689 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter: 19S-IgM-FTA-ABS-Test – IgM-SPHA-Test – IgM-Captia-Test – Treponema pallidum-spezifische IgM-Teste – Syphilisserologie ; Key words: 19S-IgM-FTA-ABS-test – IgM-SPHA-test – IgM-Captia-test – Treponema pallidum-specific IgM-tests – Syphilis serology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. A total of 359 sera of untreated patients with syphilis were examined by three methods for the detection of Treponema pallidum specific IgM antibodies, the 19S-IgM-FTA-ABS test, the IgM solid phase haemadsorption assay (IgM-SPHA), and the IgM Captia assay. The results were compared and evaluated. In primary syphilis, the 19S-IgM-FTA-ABS and IgM-Captia yielded reactive results in all patients, whereas only 40% were positive in the IgM-SPHA; the corresponding values for early latent syphilis were 96.0%, 91.5% and 73.1%, respectively. In secondary syphilis, the reactivity of █ serum out of 27 was missed by IgM-Captia and that of another, by the IgM-SPHA. Mean values (ELISA units=extinction/cut-off) of IgM-Captia were higher in primary (2.25) than in secondary syphilis (1.70). In neurosyphilis, only the IgM-SPHA test detected reactivity in all sera, sensitivity for 19S-IgM FTA-ABS and IgM-Captia was 50.0% and 23.1%, respectively. Specificity of the IgM-Captia test results, determined in 386 sera, was 91.2%. The results of specific IgM tests are essential in the diagnosis of congenital syphilis as well as in the recognition of reinfection; they indicate the need for treatment and are useful in the assessment of the effectiveness of therapy.
    Notes: Zusammenfassung. Der Aussagewert von 3 Treponema-pallidum-spezifischen IgM-Testen, dem 19S-IgM-FTA-ABS-, dem 19S-IgM-Solid-Phase-Haemadsorption-Assay (IgM-SPHA) sowie dem IgM-Captia-Test wurde an 359 Sera von unbehandelten Patienten mit bekannter Syphilisinfektion untersucht und die Ergebnisse miteinander sowie mit den Befunden der Routineserologie (FTA-ABS-, TPHA-, VDRL-Test) verglichen. Im Primärstadium (n=38) waren die Proben sämtlicher untersuchter Patienten (37/37) im 19S-IgM-FTA-ABS- und im IgM-Captia-Test, jedoch nur 14/35 (40%) im IgM-SPHA-Test reaktiv. Der FTA-ABS zeigte bei 36/38 (94,7%), der TPHA bei 32/38 (84,2%), der VDRL bei 27/38 (71,1%) die Infektion an. Im Stadium der Frühlatenz (n=53) war der 19S-IgM-FTA-ABS-Test bei 48/50 (96%) reaktiv, der IgM SPHA bei 38/52 (73,1%), der IgM-Captia bei 44/49 (89,8%), der FTA-ABS bei 53/53 (100%), der TPHA bei 51/53 (96,2%) und der VDRL bei 48/53 (90,6%). Im Sekundärstadium (n=28) war der 19S-IgM-FTA-ABS-Test bei 28/28 (100%) reaktiv, der IgM-Captia bei 26/27 (96,3%), der 19S-IgM-SPHA bei 36/52 (69,2%), der FTA-ABS, der TPHA- und der VDRL-Test bei 28/28 (100%). Bei quantitativer Auswertung (ELISA-Einheiten – Absorptions-Grenzwert) des IgM-Captia-Testes lagen die Mittelwerte im Primärstadium deutlich höher (2,25) als im Sekundärstadium (1,7). Die Sera von Patienten mit Neurosyphilis (n=45) waren im 19S-IgM-FTA-ABS-Test in 19/38 (50%) der Proben, im IgM-SPHA-Test in 45/45 (100%), im IgM-Captia in 6/26 (23,1%), im FTA-ABS in 45/45 (100%), im TPHA in 45/45 (100%) und im VDRL in 43/45 (95%) reaktiv. Schließlich wurden die Sera von 195 Personen mit latenter Syphilis von unbekannter Dauer untersucht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050150
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  • 5
    Electronic Resource
    Electronic Resource
    Clinical and pharmacokinetic studies on enoxacin in ear, nose and throat infections (1986)
    Springer
    Infection 14 (1986), S. S211 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 65 Patienten, die wegen Infektionen im Hals-Nasen-Ohren-Bereich mit 400 oder 600 mg Enoxacin zweimal täglich behandelt wurden, wurde die Wirksamkeit und Verträglichkeit von Enoxacin geprüft. Bei 32 der 60 auswertbaren Patienten war das klinische Gesamtergebnis nach Enoxacin-Behandlung ausgezeichnet, bei 17 Patienten gut, bei sechs mäßig und bei fünf schlecht. Drei Patientinnen klagten über Magendruck, ein Patient über leichte Übelkeit. Bei zwei Patienten traten allergische Hautreaktionen und bei einem Patienten Gelenk- und Muskelschmerzen auf. Die pharmakokinetischen Untersuchungen ergaben hohe Enoxacin-Konzentrationen in den untersuchten Sekreten, in Eiter und Geweben, insbesondere aus Mittelohr und Nasennebenhöhlen.
    Notes: Summary The efficacy and tolerance of enoxacin were tested in 65 patients treated for ear, nose and throat infections with doses of 400 or 600 mg b.i.d. The overall clinical efficacy of enoxacin was excellent in 32, good in 17, fair in six, and poor in five out of 60 evaluable patients. Three female patients complained of stomach pressure and one man of slight nausea, two of allergic skin reactions and one of arthromyalgia. The pharmacokinetic studies showed high enoxacin concentrations in the secretions, pus, and tissues studied, especially in those of the middle ear and the sinuses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01667846
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  • 6
    Electronic Resource
    Electronic Resource
    Mg2IrB2-x, ein Magnesium-Iridiumborid mit W2CoB2 -verwandter Struktur (1986)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 543 (1986), S. 89-96 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Mg2IrB2-x, a Magnesium Iridium Boride with a Structure Related to the W2CoB2-TypeThe new compound Mg2IrB2-x with a small homogeneity range determined approximately as 0,2 ≤ x ≤ 0,35 crystallizes monoclinically in the space group C2/m, Z=4 (lattice constants see Inhaltsübersicht). The structure which was solved by single crystal X-ray and powder neutron diffraction methods is related to the W2CoB2-type and contains distorted Mg4Ir2-prisms. The boron atoms are partly disordered. They are situated either inside the prisms forming pairs or with very short Ir-B distances (199 pm) on an elongated prism edge formed by two iridium atoms.
    Notes: Die neue Verbindung Mg2IrB2-x mit einem schmalen Homogenitätsbereich, der näherungsweise zu 0,2 ≤ x ≤ 0,35 bestimmt wurde, kristallisiert monoklin in der Raumgruppe C2/m, Z = 4. Bei x = 0,35 betragen die Gitterkonstanten a = 858,0(1) pm, b = 484,6(1) pm, c = 683,6(1) pm, β = 115°43′(1). Die Struktur, die mit Röntgen-Einkristall- und Pulver-Neutronenbeugungsmethoden bestimmt wurde, leitet sich vom W2CoB2-Typ ab und enthält verzerrte Mg4Ir2-Prismen. Die Boratome sind zum Teil fehlgeordnet. Sie befinden sich entweder innerhalb der Prismen und bilden Paare, oder sie liegen auf einer aufgeweiteten, aus zwei Iridiumatomen bestehenden Prismenkante, wobei sehr kurze Ir-B-Abstände ausgebildet werden (199pm).
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19865431211
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