ISSN:
1432-1076
Keywords:
Atrial natriuretic polypeptide
;
Cardiac disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract To investigate the atrial natriuretic polypeptide (ANP) levels in congenital heart diseases, we measured plasma immunoreactive ANP (ir-ANP) in 29 patients with left-to-righ shunt, and right auricle ir-ANP in 25 patients who underwent operation. The levels of ir-ANP in the pulmonary artery correlated with that in the femoral vein (r=0.95, P〈0.001), mean pulmonary arterial pressure (r=0.74, P〈0.001) and right atrial pressure (r=0.53, P〈0.01). The right auricle ir-ANP level was high in patients with heart failure combined with pressure or volume overload of the right atrium, as observed in tricuspid atresia, complete endocardial cushion defect, and total anomalous pulmonary venous drainage. These results suggest that the production of ANP in the atrium increases as a compensatory or secondary response to persistent release of ANP into the circulation in cardiac diseases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00441972
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