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  • 1
    Electronic Resource
    Electronic Resource
    Long-term results of the co-operative German–Austrian–Swiss osteosarcoma study group's protocol COSS-86 of intensive multidrug chemotherapy and surgery for osteosarcoma of the limbs (1998)
    Springer
    Annals of oncology 9 (1998), S. 893-899 
    Details
    ISSN: 1569-8041
    Keywords: chemotherapy ; cisplatin ; ifosfamide ; intraarterial therapy ; osteosarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In an effort to intensify osteosarcoma therapy, systemic ifosfamide was added pre- and postoperatively to an already aggressive three-drug regimen. In a subgroup of patients, loco-regional treatment intensification was attempted by using the intraarterial route to give cisplatin. Patients and methods: Patients ≤40 years at diagnosis of a localised, de novo high-grade central extremity osteosarcoma were eligible for inclusion into study COSS-86 if registered within three weeks from biopsy. Doxorubicin, high-dose methotrexate, and cisplatin were given to all patients. Patients who fulfilled one or more of three defined high-risk criteria received early systemic treatment intensification by adding ifosfamide as the fourth agent. Preoperatively, these high-risk patients received cisplatin either intraarterially or intravenously. Results: 171 eligible patients were entered, of which 128 were stratified into the high-risk group. When all 171 were analysed by intention-to-treat, actuarial overall and event-free survival rates at ten years were 72% and 66%, respectively. No benefit of intraarterial cisplatin application was detected. Cumulative treatment toxicity was considerable. Conclusions: In a multicenter setting, intensive treatment of osteosarcoma according to protocol COSS-86 led to long-term disease-free survival for two thirds of patients. We saw no benefit of using the intraarterial route to administer cisplatin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008391103132
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Arachnoidalzyste als Ursache eines Hypernatriämie-Hypodypsie-Syndroms (1998)
    Springer
    Monatsschrift Kinderheilkunde 146 (1998), S. 603-607 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Hypernatriämie ; Hypernatriämie-Hypodypsie-Syndrom ; Arachnoidalzyste ; Stereotaxie ; Kinder ; Key words Hypernatremia ; Hypodipsic-hypernatremia-syndrome ; Arachnoid cyst ; Stereotactic surgery ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Background: In rare cases a hypernatremia is caused by cerebral dysregulation. Case: We describe a 3,5 year old girl who had a hypodipsic-hypernatremia-syndrome (serum sodium concentration 194 mmol/l) caused by an arachnoid cyst in front of the pons. Therapy: In a stereotactic puncture a catheter was implanted. Aspiration of the cyst liquid did reduce the size of the cyst. For two years now no other treatment is given. Hypernatremia did not occur again. Discussion: To our knowledge this is the first case of a hypodipsic-hypernatremia-syndrome caused by an arachnoid cyst, which was cured by a single operation.
    Notes: Zusammenfassung Hintergrund: In seltenen Fällen werden Hypernatriämien durch zerebrale Regulationsstörungen verursacht. Fall: Wir berichten von einem 3,5 Jahre alten Mädchen, bei dem ein Hypernatriämie-Hypodypsie-Syndrom (Serumnatrium 194 mmol/l) durch eine präpontine Arachnoidalzyste verursacht wurde. Therapie: Durch eine stereotaktische Operation wurde ein Katheter implantiert. Der Zysteninhalt wurde aspiriert und die Zyste dadurch verkleinert. Seit 2 Jahren trat ohne medikamentöse Therapie keine Hypernatriämie mehr auf. Diskussion: In diesem Fall konnte nach unserem Wissen erstmals ein Hypernatriämie-Hypodypsie- Syndrom, das durch eine Arachnoidalzyste verursacht wurde, durch eine Operation geheilt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050300
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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