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  • 2005-2009
  • 2000-2004  (6)
  • 1985-1989
  • 1910-1914
  • 2000  (6)
  • 1
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Laser plasma interactions in a relativistic parameter regime have been intensively investigated for studying the possibility of fast ignition in inertial confinement fusion (ICF). Using ultra-intense laser systems and particle-in-cell (PIC) simulation codes, relativistic laser light self-focusing, super hot electrons, ions, and neutron production, are studied. The experiments are performed with ultra-intense laser with 50 J energy, 0.5–1 ps pulse at 1053 nm laser wavelength at a laser intensity of 1019 W/cm2. Most of the laser shots are studied under preformed plasma conditions with a 100 μm plasma scale length condition. In the study of laser pulse behavior in the preformed plasmas, a special mode has been observed which penetrated the preformed plasma all the way very close to the original planar target surface. On these shots, super hot electrons have been observed with its energy peak exceeding 1 MeV. The energy transport of the hot electrons has been studied with making use of Kα emissions from a seeded metal layer in planar targets. The details of ion acceleration followed by beam fusion reaction have been studied with neutron spectrometers. Laser ponderomotive force self-focusing and hot electron generation have been applied to a compressed core to see the effect of heating by injecting 12 beams of 100 ps, 1 TW pulses. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0649
    Keywords: PACS: 33.00; 34.00; 36.00
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. X-ray spectra from nitrogen clusters irradiated with ultrashort laser pulses are reported. The line spectra of H-like and He-like nitrogen ions have been observed by irradiation with 100 fs, 800 nm pulses at 7×1017 W/cm2 irradiance. The generation of highly charged ions of N6+ and N7+ is explained by the optical field-induced ionization and the subsequent collisional ionizations in the clusters. The He-δline has anomalously high brightness compared to other He-like lines. It is ascribed to charge exchange, which preferentially populates the n=5 level of N5+.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1090-6487
    Keywords: 52.40.Nk.408
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A method is proposed for generating collimated beams of fast ions in laser-plasma interactions. Two-dimensional and three-dimensional particle-in-cell simulations show that the ponderomotive force expels electrons from the plasma region irradiated by a laser pulse. The ions with unneutralized electric charge that remain in this region are accelerated by Coulomb repulsive forces. The ions are focused by tailoring the target and also as a result of pinching in the magnetic field produced by the electric current of fast ions.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Dihydropyrimidinase-related proteins (DRPs) are involved in axonal outgrowth and pathfinding. However, little is known about their significance in the enteric nervous system (ENS), the largest and most complex division of the peripheral nervous system. Using in situ hybridization (ISH) and northern blotting, we examined mRNA expression of DRP-1–4 transcripts in the developing and adult mouse digestive tract and in the adult human colon. ISH detected the mouse DRP-3 transcript in the developing ENS on embryonic day (E)12 and at the later stages as well as in the adult intestine. Mouse DRP-1 and -2 transcripts appeared at E14. DRP-2 transcript was also detected in the adult intestine although DRP-1 expression was lower in the adult. DRP-4 gene was not expressed in the ENS during development or adulthood whereas the signal was apparent in the developing and adult central nervous system (CNS). The DRP expression pattern in the human colon was similar to that of the mouse large intestine. Northern blot analysis showed that DRPs were differentially expressed in the mouse and human intestines, supporting the results of ISH. These data suggest that DRPs play a role not only in the CNS but also in the ENS.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1211
    Keywords: Key words MASP ; Lectin pathway ; Complement ; Truncated form ; Alternative polyadenylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  The mannose-binding lectin (MBL) and MBL-associated serine proteases (MASPs) play crucial roles in activation of the lectin pathway of the complement system. Mammals and Xenopus possess two distinct MASPs, MASP1 and MASP2, with different substrate specificity. Recently, a truncated form named MAp19 or sMAP, composed of N-terminal C1r/C1s/Uegf/bone morphogenetic protein (CUB)-1 and epidermal growth factor domains of MASP2, has been shown to be generated by alternative polyadenylation and splicing from the MASP2 gene. In the present study, we isolated cDNA encoding a novel MASP-related protein, designated MRP, from carp. MRP is distinct from MAp19/sMAP in containing two additional domains, CUB-2 and short concensus repeat (SCR)-1, followed by a unique C-terminal 21 amino acids, but resembles it by also lacking the serine protease domain, suggesting that carp MRP is a functional homologue of human MAp19/sMAP. Analyses of polymerase chain reaction (PCR)-amplified carp genomic DNA, from CUB-2 to SCR-2 of MASP, indicated that carp possess duplicated MASP genes, designated MASP-A and MASP-B, both of which contain an exon encoding the MRP-specific C-terminal stretch between the exons coding for SCR-1 and SCR-2 domains. Reverse transcription-PCR analysis showed that both MASP genes of carp produce the two MASP isoforms, MASP and MRP, through alternative polyadenylation and splicing. The conservation of MASP isoforms that lack the catalytic domain in both carp and human implies that they meet an essential requirement in the MBL-MASP complex of the lectin pathway.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Surgical endoscopy and other interventional techniques 14 (2000), S. 1149-1152 
    ISSN: 1432-2218
    Keywords: Key words: Breast cancer — Internal mammary node — Lymph node dissection — Thoracoscopic surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: This pilot study was conducted to estimate the use of the thoracoscopic surgery as a new approach for the internal mammary nodes (IMN) in breast cancer. Patients and methods: For this study, 21 women with breast cancer who underwent the approach for nodes IMN were enrolled. All the women had suspicious IMN metastasis and no distant metastasis. Results: Thoracoscopic IMN dissection was performed safely for 20 of the women, with an average operative time of 44 min. One woman was excluded from the procedure because of pleural adhesion. The patients were restricted from walking for 1.3 days because of chest drainage, but no patients had severe complication or chest wall deformity after the operation. Six patients had positive IMN outcomes. After surgery, 10 of the 20 patients had a lower tumor node metastases (TNM) staging. Two patients who tested positive for IMN and three who tested negative experienced a relapse, but none had pleural dissemination in a median follow-up period of 24 months. Conclusion: Thoracoscopic surgery may be useful in managing patients with IMN.
    Type of Medium: Electronic Resource
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