Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Does the migraine aura reflect cortical organization? (2000)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 12 (2000), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Individuals suffering from classical migraine report an astonishing diversity of migraine auras. A frequently reported symptom is a visual hallucination known as fortification illusion (FI). Here we demonstrate that the typical zig-zag pattern of the FI can be reproduced using experimental data of orientation maps of the primary visual cortex (V1) assuming that a continuous excitation front propagates across V1. We put forward a model in which the cortical neurons within this excitation wave are activated sufficiently to contribute to conscious perception. It is shown that the discontinuous repetitive nature of the zig-zag pattern of the FI can reflect the specific layout of visual cortical orientation maps. Additionally, dynamic features of the FI are predicted based on our model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2000.00995.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Facet degradation of high-power diode laser arrays (2000)
    Springer
    Applied physics 70 (2000), S. 377-381 
    Details
    ISSN: 1432-0630
    Keywords: PACS: 42.55.P; 68.60.D; 78.30.F
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. Micro-Raman facet temperatures of high-power diode lasers with different waveguide architectures are compared. For regular operation conditions, the thermal behavior of ‘unaged’ arrays emitting in the 808-nm wavelength region with different architectures is similar, however, with an increased load thermal behaviors differ significantly and exhibit failure events at facet temperatures typically between 150 and 450 °C. From various experiments, among them facet temperature measurements for ultrahigh-power operation as well as by preparative failure analytics, we provide evidence that in arrays the front facets are significantly affected by device operation and influence the failure behavior of the whole high-power diode laser also in cases when the device failure is accompanied by dislocation creation inside the device.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003390051051
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Notfallmanagement in der HNO-Praxis Teil 1: Basismaßnahmen (2000)
    Springer
    HNO 48 (2000), S. 323-329 
    Details
    ISSN: 1433-0458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Notfallsituationen in der HNO-ärztlichen Praxis sind zwar selten, dann aber stellen sie den Arzt und seine Mitarbeiter vor eine Situation, auf die er in der Regel nicht ausreichend vorbereitet ist. Organisatorisches Chaos und teilweise Hilflosigkeit sind die Folgen, die unter medizinischen, aber auch unter juristischen Aspekten zu fatalen Konsequenzen führen können. Ein richtiges Handeln in Notfallsituationen ist dabei nicht schwer, wenige grundlegende Maßnahmen können Ihren Patienten und Sie absichern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050574
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Notfallmanagement in der HNO-Praxis Teil 3: Spezielle Notfälle B (2000)
    Springer
    HNO 48 (2000), S. 477-480 
    Details
    ISSN: 1433-0458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Im letzten Teil unserer Notfallmanagement-Reihe wird nochmal praxisbezogen und für den notfallmedizinisch ungeübten Arzt auf relevante Notfallsituationen in der HNO-Praxis eingegangen. Dargestellt werden in dieser Ausgabe die folgenden Notfallsituationen in alphabetischer Reihenfolge: ·Herzinfarkt ·Hyperventilationstetanie ·Hypoglykämie ·Krampfanfall ·Lungenödem ·Schlaganfall ·Vasovagale Synkope
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050601
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Aktuelle radioonkologische Strategien bei der Behandlung von malignen Tumoren im Kindesalter (2000)
    Springer
    Der Onkologe 6 (2000), S. 854-867 
    Details
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: In den letzten Jahrzehnten hat sich der Stellenwert der Strahlentherapie bei der Behandlung pädiatrischer Tumoren gewandelt. Fortschritte auf dem Gebiet strahlentherapeutischer Techniken und Kenntnisse über notwendige Dosierungen für eine maximale Tumorkontrolle bei minimaler Nebenwirkungsrate (Dosis-Wirkungs-Beziehungen) erlauben eine effiziente und schonende Bestrahlung mit Anhebung der Überlebenszeiten bei gleichzeitiger Reduktion von Therapiefolgen, ohne jedoch die Metastasierungstendenz wesentlich zu beeinflussen. Die Einführung von Chemotherapien erreichte eine zusätzliche systemische Tumorkontrolle, sodass heute bei der überwiegenden Mehrheit der Erkrankungen Heilungsraten erzielt werden, die 70% übersteigen (Tabelle 1). Während im Erwachsenenalter vorwiegend Tumoren epithelialen Ursprungs im Vordergrund stehen, werden Tumoren im Kindesalter vorwiegend durch Neoplasien embryonaler Genese gebildet. Diese zeigen eine erhöhte Empfindlichkeit gegenüber ionisierender Strahlung und chemotherapeutischen Substanzen. Hierdurch werden die im Vergleich zum Erwachsenenalter deutlich erhöhten Heilungsraten erklärt. Gleichzeitig reagiert aber der wachsende Organismus sensibler auf zytotoxische Agenzien. Einige chemotherapeutische Substanzen können zwar durch einen strahlensensibilisierenden Effekt die Tumorkontrolle verbessern, erhöhen jedoch gleichzeitig das Risiko für akute, maximale Nebenwirkungen und Spätfolgen (Tabelle 2). Hierdurch können nicht nur einzelne Organfunktionen beeinträchtigt werden, sondern auch die gesamte Entwicklung des betroffenen Kindes. Die Dosisschwelle für die Toleranz des kindlichen Gewebes v. a. der sich entwickelnden Organe liegt häufig unter den Dosierungen, die für die lokale Tumorkontrolle notwendig sind, und ändern sich durch eine zusätzliche Chemotherapie. Daher werden spezielle Anforderungen an die Strahlentherapie gestellt, um Normalgewebe und v. a. Risikoorgane zu schonen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007610070053
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Notfallmanagement in der HNO-Praxis Teil 2: Spezielle Notfälle (2000)
    Springer
    HNO 48 (2000), S. 401-404 
    Details
    ISSN: 1433-0458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Im Folgenden werden einige für die HNO-Praxis relevante Notfallsituationen und ihre Behandlungsmöglichkeiten in Kurzform dargestellt. Die Therapieschemata wurden dabei bewusst so gewählt, dass diejenigen Maßnahmen, die auch vom notfallmedizinisch ungeübten Arzt oder seinen Mitarbeitern ohne aufwendige invasive Methoden durchgeführt werden können, im Vordergrund stehen. Dargestellt werden in dieser Ausgabe der “HNO” die folgenden Notfallsituationen in alphabetischer Reihenfolge: · Anaphylaktischer Schock · Angina pectoris · Akuter Asthmaanfall · Bluthochdruck mit Hypertensiver Krise · Blutungen · Bolusgeschehen
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050589
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Rigorous Bounds for the Föppl—von Kármán Theory of Isotropically Compressed Plates (2000)
    Springer
    Journal of nonlinear science 10 (2000), S. 661-685 
    Details
    ISSN: 1432-1467
    Keywords: Key words. thin film elasticity, blistering, von Kármán theory of plates, optimal scaling laws
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Summary. We study the Föppl—von Kármán theory for isotropically compressed thin plates in a geometrically linear setting, which is commonly used to model weak buckling of thin films. We consider generic smooth domains with clamped boundary conditions, and obtain rigorous upper and lower bounds on the minimum energy linear in the plate thickness σ . This energy is much lower than previous estimates based on certain dimensional reductions of the problem, which had lead to energies of order 1+σ (scalar approximation) or σ 2/3 (two-component approximation).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003320010007
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Recombinant Components of the EcoRII Restriction–Modification System: Restriction Endonuclease Can Interact with DNA · RNA Duplexes (2000)
    Springer
    Molecular biology 34 (2000), S. 913-920 
    Details
    ISSN: 1608-3245
    Keywords: EcoRII restriction endonuclease ; EcoRII methylase ; histidine derivatives ; DNA–RNA hybrids ; nucleic acid–protein interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract To obtain recombinant restriction endonuclease (R) and methylase (M) of the EcoRII restriction–modification system, bacterial strains overproducing their functional hexahistidine derivatives were constructed. Active full-length R · EcoRII was produced only in cells that also expressed M · EcoRII from a multicopy plasmid. Recombinant R · EcoRII bound with hybrid DNA · RNA duplexes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026688028427
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Rational Design and Synthesis of Ribozymes (2000)
    Springer
    Molecular biology 34 (2000), S. 934-939 
    Details
    ISSN: 1608-3245
    Keywords: catalytic RNA ; ribozyme design ; RNA synthesis ; fluorescent oligonucleotides ; reaction kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We review our procedure for the rational design and the synthesis of oligoribonucleotides with particular reference to our recent studies of the development of a hairpin-derived twin ribozyme. Our work focuses on the design of ribozymes that are derived from naturally occurring structures but posses extended catalytic activities. Currently we are studying ribozymes that are capable of site-specific RNA double cleavage. We have designed these “twin ribozymes” by combining of two catalytic motifs in one molecule. In addition to kinetic analysis of the cleavage reaction, we are interested in the general phenomena of RNA folding and the characterization of RNA structure–function relationships. The developed twin ribozymes are particularly well suited for this purpose. They have to fold into a complex structure to achieve catalytic activity. Since there is a direct correlation between conformation and activity, the process of folding can be followed by monitoring the cleavage reaction. The twin ribozymes were synthesized by a combination of phosphoramidite chemistry and in vitro transcription techniques. We report the synthesis of a powerful reagent to replace tetrazole for activation of RNA phosphoramidites in automated solid-phase synthesis, allowing for coupling yields of 〉99%. Furthermore, we introduce a fast quantitative assay of ribozyme activity which is based on fluorescently labeled oligoribonucleotide substrates and DNA sequencer technology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026644313406
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...