Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 14 (2000), S. 0 
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Granulomatous mycosis fungoides is an extremely rare type of cutaneous T-cell lymphoma. Two cases are described and checked for clinical, histological and therapeutic differences to other variants of mycosis fungoides.Case reports Case 1: a 52-year-old patient with livid plaques covering the whole integument. Histological findings showed granulomas with multinuclear giant cells in addition to a malignant lymphohistiocytic infiltrate (monoclonal T-cell receptor (TCR) -γ rearrangement). Despite various chemotherapeutic regimens, progression to tumour stage was observed. Case 2: an 88-year-old man with plaques and ulcerating tumours on the trunk and head. Histological findings showed malignant T-lymphocyte infiltrate (monoclonal TCR-γ rearrangement) and granulomas with multinuclear foreign-body giant cells. Complete regression of all lesions was achieved using both local psoralen-ultraviolet A and electron radiotherapy.Conclusions The diagnosis of a granulomatous mycosis fungoides depends exclusively on the histological demonstration of granulomas. Distinct clinical characteristics are not present. Apart from granuloma formation, no other noticeable histological features are evident. The presence of granulomas in mycosis fungoides does not have prognostic implications, as cases with aggressive, but also with a prolonged course have been described.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Nutrition 20 (2000), S. 153-167 
    ISSN: 0199-9885
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate as substrates. The imidazole ring of GTP is hydrolytically opened, yielding a 4,5-diaminopyrimidine which is converted to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione by a sequence of deamination, side chain reduction and dephosphorylation. Condensation of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione with 3,4-dihydroxy-2-butanone 4-phosphate obtained from ribulose 5-phosphate affords 6,7-dimethyl-8-ribityllumazine. Dismutation of the lumazine derivative yields riboflavin and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione, which is recycled in the biosynthetic pathway. The structure of the biosynthetic enzyme, 6,7-dimethyl-8-ribityllumazine synthase, has been studied in considerable detail.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 33 (2000), S. 605-608 
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: The analysis of dendrimers of fourth (G4) and fifth generation (G5) by small-angle Neutron scattering (SANS) in solution is presented. The contrast of the solute towards the solvent is changed systematically in order to elucidate the radial scattering length density (contrast variation). Contrast variation allows to determine the molecular weight of the dendrimers without additional assumptions. The data obtained here demonstrate that the dendrimer of fourth generation is a perfect structure whereas G5 has defects. Moreover, the analysis demonstrates that both dendrimer under consideration here have a compact structure where the density has its maximum at the center of the molecule.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1437-1588
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Cochlear Implant ; Ambulante Rehabilitation ; Kinder ; Erwachsene ; Ergebnisse ; Keywords Cochlear implant ; Outpatient rehabilitation ; Cost effectiveness ; Results ; Children ; Adults
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background and objective. This study compares the results of the outpatient-based program of the Cochlear Implant Center Ruhr with inpatient-based rehabilitation, which is almost exclusively performed in Germany. Patients/methods. The Department of Otorhinolaryngology at the University of Essen in Germany provided 52 patients with either 22- or 24-channel Nucleus cochlear implants from March 1996 to July 1999. Almost all patients (n=49) were rehabilitated on an outpatient basis, which is the standard in many cochlear implant centers outside Germany. Results. The longest follow-up period at the University of Essen Department of Otorhinolaryngology was 36 months. Minor complications occurred in 10% of the patients. After 24 months, the first three implanted patients were able to discriminate 100% of numbers and over 60% of syllables in the Freiburg speech discrimination test. The patients who developed an understanding of open speech were able to discriminate 31 words per minute with cochlear implant and without lipreading after 24 months. Children were seen to double their Schmid-Giovannini scores at 6 months postimplantation. Conclusions. The Essen outpatient-based cochlear implant program demonstrates results in speech development and speech understanding equal to those of centers providing inpatient rehabilitation. A special advantage is continuous rehabilitation with professionals known to the child for several years. In children especially, exhaustive commuting reduces school attendance and is a burden on the accompanying guardians. As an inpatient, however, the child is torn from his familiar environment. Parents with several children have particular difficulties in accompanying their child and indeed this may not always be possible.
    Notes: Zusammenfassung Hintergrund und Fragestellung. In dieser Arbeit werden die Ergebnisse der ambulanten Rehabilitation nach Cochlear-Implant-Versorgung mit denen der stationären Rehabilitation verglichen, die bisher in Deutschland fast ausschließlich durchgeführt wird. Von März 1996 bis Juli 1999 wurden an der Universitäts-Hals-Nasen-Ohren-Klinik Essen 52 taube oder an Taubheit grenzende Patienten mit einem 22-kanaligen bzw. 24-kanaligen Nucleuscochlear-Implant versorgt. Fast alle Patienten (n=49) konnten wohnortnah ambulant rehabilitiert werden, wie dies dem internationalen Standard entspricht. Ergebnisse. Der längste bisherige Nachbeobachtungszeitraum an der Universitäts-Hals-Nasen-Ohren-Klinik Essen sind 36 Monate. Nach 2 Jahren wurden von den 3 am längsten nachbeobachteten Patienten 100% der Zahlen und über 60% der Einsilber im Freiburger Sprachtest verstanden. Im “speech tracking” erreichten Patienten mit CI und ohne Lippenabsehen nach 24 Monaten 31 Wörter/min. Die Kinder zeigten 6 Monate nach Implantation eine Verdopplung des Scores im Test nach Schmid-Giovannini. Schlussfolgerungen. Das Essener Modell zeigt, dass eine ambulante Rehabilitation nach CI zu vergleichbaren Ergebnissen in der Sprachentwicklung und im Sprachverstehen führt, wie sie von anderen Zentren vorgelegt wurden, in denen fast ausschließlich stationär rehabilitiert wird. Besonders bei Kindern bedeuten lange Anfahrtswege mit einwöchigem stätionärem Aufenthalt Schulausfälle und eine Belastung für die begleitenden Eltern und Familienangehörigen zu Hause, sowie erhebliche Fahrtkosten. Stationäre Aufenthalte zur Rehabilitation reißen zudem das Kind aus seiner gewohnten Umgebung und sind für Eltern mit mehreren Kindern oft unmöglich.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    HNO 48 (2000), S. 45-48 
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Extrapulmonal ; Inflammatorischer Pseudotumor ; Nase ; Key words Extrapulmonary neoplasms ; Pseudotumor ; Nasal pathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary An inflammatory pseudotumor occurs unifocally and is a benign tumor that was initially described in the lung. In the present case report a 24-year-old woman experienced progressive nasal obstruction because of an abnormallity of the nasal septum. A cauliflower-like tumor of the anterior region of the septum cartilage was seen macroscopically and was completely resected. This was diagnosed histologically as an inflammatory pseudotumor. The literature is reviewed and differential diagnoses discussed. Various therapeutic procedures are noted, but the treatment of choice is complete resection of tumor.
    Notes: Zusammenfassung Der inflammatorische Pseudotumor tritt in der Regel singulär auf und ist ein benigner Tumor, der erstmals in der Lunge beschrieben wurde. Beschrieben wird der Fall einer 24jährigen Frau mit progredienter Nasenatmungsbehinderung infolge einer Verdickung des vorderen Septums. Makroskopisch zeigte sich ein blumenkohlartiger Tumor im Bereich des vorderen Septumknorpels, der vollständig reseziert wurde. Histologisch handelte es sich um einen inflammatorischen Pseudotumor. Anhand eines Überblicks über die relevante Literatur werden Differentialdiagnosen diskutiert. Die Therapie der Wahl besteht in einer vollständigen chirurgischen Resektion des Tumors.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1433-044X
    Keywords: Schlüsselwörter 20-MHz-Sonographie ; Thermische Narben im Kindesalter ; Therapieobjektivierung ; Keywords 20-MHz-Sonographie ; Epidermal thermal scars in children ; Objectification of treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract So far, little is known about the acoustic phenomena of high-frequency sonography for the assessment of healing processes in thermal wounds. However, ex vivo investigations have shown clear age-dependent differences in the rate of sound propagation i thermal scars compared th healthy skin. In order to answer the question of whether measurable acoustic characteristics of burn or scald scars can be classified in a way which corresponds to the clinical severity of the injuries, age of scar or type of treatment, 92 thermal scars, with an average scar age of 3.1 years, in 55 children were investigated with regard to corium thickness and echogenicity. A control group of 25 non-injured children of similar age was studied for comparison. It was shown that measurable echogenicity differences can allow conclusions about clinical severity to be drawn. The comparison of different therapeutic strategies showed no therapeutic effect either for compression or for the application of silicone gel sheets. In contrast, a decrease in scar thickness and a loosening of scar structure could be seen after early application of a sterile, silicone-covered polyamide net bandage. The 20-MHz-Sonographie is a suitable non-invasive procedure for the characterisation of burn scars.
    Notes: Zusammenfassung Über akustische Phänomene der hochfrequenten Sonographie zur Beurteilung der Heilung thermischer Wunden ist bisher wenig bekannt. Lediglich Ex-vivo-Untersuchungen haben gezeigt, dass deutliche Unterschiede der Schallausbreitungsgeschwindigkeit in thermischen Narben in Abhängigkeit vom Narbenalter im Vergleich zur gesunden Haut bestehen. Zur Frage, ob die messbaren akustischen Eigenschaften von Verbrennungs- oder Verbrühungsnarben eine Zuordnung entsprechend dem klinischen Schweregrad der Verletzung, dem Narbenalter oder dem Behandlungsverfahren zulassen, wurden 92 thermische Narben bei 55 Kindern mit einem durchschnittlichen Narbenalter von 3,1 Jahren bezüglich der Koriumdicke und der Koriumechogenität untersucht. Vergleichend dazu wurden eine Kontrollgruppe von 25 unverletzten Kindern vergleichbaren Alters vermessen. Es kann festgestellt werden, dass messbare Echogenitätsunterschiede mit Rückschluss auf den klinischen Schweregrad zulassen. Der Vergleich verschiedener therapeutischer Strategien zeigt weder für die Kompression noch für die Anwendung von Silikongelplatten einen therapeutischen Effekt. Nach der frühzeitigen Anwendung eines sterilen, silikonbeschichteten Polyamidnetzes hingegen lässt sich eine Abnahme der Narbendicke und eine Auflockerung der Narbenstruktur nachweisen. Die 20-MHz-Sonographie ist als nichtinvasives Verfahren für die Charakterisierung von Verbrennungsnarben geeignet.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 49 (2000), S. 721-724 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Schulterarthroskopien ; Morphin ; Impingementsyndrom ; Keywords Intra-articular morphine ; Shoulder arthroscopy ; Subacromial space ; Peripheral opioid receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Peripheral opiod receptors have been found in inflamed synovia and the analgesic effect of intra-articularly administered morphine after arthroscopic knee surgery has been proven. There is controversy about effiacy of intraarticular morphine after shoulder arthroscopy. Thirtytwo patients with impingement syndrome underwent subacromial decompression in the course of arthroscopic shoulder surgery. At the end of the operation morphine (5 mg) or saline was injected periarticularly. Pain intensity (rest and passive mobilisation) was recorded after recovery and after 1, 2, 4, and 24 hours (Numeric Rating Scale); the use of rescue medication (piritramide by patient controlled analgesia) was noted. No relevant pain reduction was apparent in the morphine group. Piritramide consumption was identical in both groups (19,7±16 mg vs. 19,8±19 mg). We conclude that periarticularly administered morphine in arthroscopic subacromial decompression in the dosage applied in this study does exert no relevant analgesic effect. This is possibly due to the fact that either subacromial tissue, despite of chronic inflammation, does not show the same reagibility as synovia or it is a problem of the nearly complete resection of the subacromial bursa.
    Notes: Zusammenfassung Fragestellung. Die Existenz peripherer Opiatrezeptoren in entzündlicher Kniegelenkssynovia ist nachgewiesen und die analgetische Wirksamkeit intraartikulär applizierten Morphins nach Kniegelenksarthroskopien belegt. Ob ein solcher Therapieansatz auch für Schulterarthroskopien gilt, ist ungeklärt. Methodik. Bei 32 Patienten mit Impingementsyndrom wurde im Rahmen einer Schulterarthroskopie eine subakromiale Dekompression durchgeführt. Zum Operationsende wurden 5 mg Morphin oder NaCl 0,9% arthroskopisch in den Subakromialraum instilliert. Der postoperative Ruhe- und Belastungsschmerz wurde nach Erwachen sowie nach 1, 2, 4 und 24 h erhoben (Numeric Rating Scale, NRS) und der Bedarf einer Ausweichmedikation (Piritramid als Patientenkontrollierte Analgesie, PCA) erfaßt. Ergebnisse. Es zeigte sich keine klinisch relevante Schmerzreduktion in der Verumgruppe. Der Piritramidverbrauch über 24 h war in beiden Gruppen gleich (19,7±16 mg vs.19,8±19 mg). Schlußfolgerungen. Periartikulär verabreichtes Morphin bei Schulterarthroskopien erzeugt in der hier verwendeten Dosierung keine klinisch relevante analgetische Wirkung. Dies kann in der Operationstechnik begründet sein, aber auch in einer im Vergleich zur Synovia anderen Reagibilität des subakcromialen Bindegewebes.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Zink ; Atopische Dermatitis ; Psoriasis ; Keywords Zinc ; Atopic dermatitis ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background and Objective. The significance of zinc in the pathogenesis of different dermatological conditions is controversial. Using our own patient collective, the present study aimed to determine variations in serum zinc levels in patients with atopic dermatitis and psoriasis as compared to levels in the normal population. Patients/Methods. The serum zinc levels of 97 patients with atopic dermatitis and 88 patients with psoriasis were compared to those in 22 healthy subjects and subjected to statistical analysis. Results. In contrast to the data given in the literature, no statistically significant difference was found between the populations investigated. Conclusions. Zinc replacement therapy in patients with atopic dermatitis and psoriasis appears to be indicated only in those with a documented zinc deficiency.
    Notes: Zusammenfassung Hintergrund und Fragestellung. Die Bedeutung von Zink wird bei der Pathogenese verschiedener Hauterkrankungen diskutiert. Ziel der vorliegenden Studie war es, anhand des eigenen Patientengutes Änderungen des Serumzinkspiegels bei Patienten mit atopischer Dermatitis und Psoriasis vulgaris im Vergleich zur Normalpopulation zu ermitteln. Patienten/Methodik Es wurden die Serumzinkspiegel von 97 Patienten mit atopischer Dermatitis und 88 Patienten mit Psoriasis vulgaris im Vergleich zu 22 gesunden Kontrollpersonen bestimmt und statistisch ausgewertet. Ergebnisse. Es zeigten sich entgegen den in der Literatur beschriebenen Daten keine statistisch signifikanten Unterschiede zwischen den untersuchten Populationen. Schlussfolgerungen. Eine medikamentöse Zinksubstitution erscheint vor diesem Hintergrund nur bei einem nachweisbaren Serumzinkmangel als indiziert.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Experimental mechanics 40 (2000), S. 138-153 
    ISSN: 1741-2765
    Keywords: Kolsky bar ; dynamic friction ; manufacturing ; wear
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A novel dynamic friction experiment using the Kolsky bar concept was developed. The technique is complementary to the plate impact and other macroscopic friction experiments in the sense that sliding velocities and pressures not attainable otherwise can be investigated. The experimental results reported in this article show that the technique provides accurate and repeatable measurement of time-resolved friction. The apparatus is simpler and easier to operate than the plate impact facility. However, it cannot achieve the same level of contact pressure. Several material pairs have been investigated. In particular, the kinetic friction coefficient of Ti-6Al-4V sliding against WC/Co (cermet) and 4340 steel sliding against WC/Co were measured and compared with the values reported by Prakash and Clifton in 1993. Atomic force microscopy is used to characterize the surface topography before and after the friction tests.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...