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  • 1
    Electronic Resource
    Electronic Resource
    Primary extranodal CD8 positive epitheliotropic T-cell lymphoma arising in a leiomyoma of the uterus (2003)
    Oxford, UK : Blackwell Science Ltd
    BJOG 110 (2003), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-0528.2003.01073.x
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  • 2
    Electronic Resource
    Electronic Resource
    Allergic contact stomatitis from BIS-GMA and epoxy resins in dental bonding agents (2003)
    Oxford, UK : Munksgaard International Publishers
    Contact dermatitis 49 (2003), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2003.0128b.x
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of storage on allergen and microbial agent levels in frozen house dust (2003)
    Oxford, UK : Munksgaard International Publishers
    Allergy 58 (2003), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: House dust samples collected for exposure studies are often stored for variable time periods until analysis. However, there is currently no information on the effects of dust storage on the content of biocontaminants. Therefore, associations were analysed between the levels of mite allergens (Der p 1, Der f 1), cat allergen (Fel d 1) and microbial components (endotoxin, β(1→3)-glucan) on the one hand and the storage duration of dust samples at −20°C on the other hand.Methods: Within the framework of a study on the influences of INdoor factors and Genetics on Asthma (INGA), dust samples were collected from living room floors between June 1995 and August 1998 and extracted according to a standardized protocol. The concentrations of Der p 1, Der f 1, Fel d 1 and β(1→3)-glucan were determined with specific enzyme immunoassays. Endotoxin content was quantified using a chromogenic kinetic Limulus amoebocyte lysate (LAL) test. All concentrations were expressed per gram of dustResults: Dust samples (n = 1236) were obtained from 655 homes in Hamburg, Hettstedt, Zerbst and Bitterfeld. Storage duration (range 8–298 days) was grouped into four categories (≤ 60 d; 61–90 d; 91–120 d; 〉 120 d). After adjustment for city of residence and season of dust sampling, means ratios comparing categories 2–4 to the first category were not statistically significant for Der p 1, Der f 1, endotoxin and β(1→3 glucan). However, Fel d 1 concentrations significantly declined with increased storage times of dust samples.Conclusions: Storage of house dust at −20°C for up to 10 months has no effect on mite allergen, endotoxin and β(1→3)-glucan levels. A potential loss of Fel d 1 during storage of frozen dust samples needs further investigations by repeated measurements of allergen in identical dust samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2003.00036.x
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  • 4
    Electronic Resource
    Electronic Resource
    Functional properties and interaction of the anterior and posterior intraparietal areas in humans (2003)
    Oxford, UK : Blackwell Science, Ltd
    European journal of neuroscience 17 (2003), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In the monkey the lateral bank of the anterior part of the intraparietal sulcus (area AIP), contains neurons that are involved in visually guided, object-related hand movements. It has also been shown that neurons in the caudal part of the intraparietal sulcus (area CIP) preferentially respond to 3D surface orientation. According to these results, it has been hypothesized that neurons in area CIP primarily encode the 3D features of an object and forwards this information to area AIP. AIP then utilizes this information for appropriate hand actions towards the object. Based on analogies to these primate studies, recent neuroimaging studies have suggested human homologues of areas AIP and CIP, however, the functional interaction between these areas remains unclear. Our event related fMRI study was designed to address specifically the question, how CIP and AIP interact in the process of adjustment of hand orientation towards objects. Volunteers were asked to perform three tasks: discrimination of surface orientation, imaging of visually guided hand movements and execution of visually guided hand movements. Our data show that the human AIP was activated both during discrimination of surface orientation and during the subsequent spatial adjustment of the thumb and index finger position towards the surface orientation. In contrast, human CIP was activated by the surface orientation but not by spatial adjustment of finger position. These data clearly indicate that the function of human CIP is more involved in coding 3D features of the objects, whereas human AIP is more involved in visually guided hand movements, similar to its role in the monkey.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2003.02540.x
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  • 5
    Electronic Resource
    Electronic Resource
    Validation of an environmental exposure unit for controlled human inhalation studies with grass pollen in patients with seasonal allergic rhinitis (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background There is an increasing need for allergen inhalation systems to perform basic clinical research and test anti-allergic drugs under well-controlled conditions. This requires stability of environmental conditions like temperature and humidity, as well as allergen concentration and reproducible induction of allergic symptoms.Objective The aim of this study was to validate an environmental exposure unit for controlled human pollen inhalation studies in participants with seasonal allergic rhinitis.Methods Temperature, relative humidity, and air flow rate were kept constant with an air conditioning system. Pollen atmosphere was generated using a specially designed feeding system and monitored online by laser counter and offline using rotating rod samplers. Efficacy (total nasal symptom score, nasal air flow rate, nasal secretion) and safety (lung function) parameters were evaluated at different pollen concentrations and repeated allergen challenges.Results Temperature, humidity, and air flow rate in the environmental exposure unit remained constant within a range of 〈2%. The spatial distribution and the temporal stability of the pollen concentration varied only slightly over 4 h (±10% and 〈4%, respectively). Dose-dependent induction of allergic rhinitis symptoms, reduction in nasal air flow rate, and increase in nasal secretion were observed over time. These effects were reproducible from day to day. Lung function remained clinically normal at all concentrations and from day to day.Conclusions Thus, pollen exposure in the environmental exposure unit is an effective, reproducible, safe, and suitable method for single-centre clinical studies on the efficacy of anti-allergic treatment or basic clinical research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2003.01810.x
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  • 6
    Electronic Resource
    Electronic Resource
    Patch testing with components of water-based metalworking fluids (2003)
    Oxford, UK : Munksgaard International Publishers
    Contact dermatitis 49 (2003), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Water-based metalworking fluids (MWFs) may cause both irritant and allergic contact dermatitis. Several well-known MWF allergens are available for patch testing, but considering the wide variety of possible components used in MWF, our diagnostic arsenal covers only a small part of potential allergens. We therefore selected 13 frequently used MWF components that might be sensitizers and had not yet been tested routinely. In 5 centres, 233 dermatitis patients with present or past occupational exposure to MWF were patch tested with this and other panels. Only 7 patients showed positive reactions to the study panel. Allergic reactions to the emulsifier diglycolamine [syn. 2-(2-aminoethoxy) ethanol] were seen in 5 patients, and 1 patient each reacted positively to 2-amino-2-ethyl-1,3-propanediol (AEPD) and methyldiethanolamine (MDEA). Clinical relevance of the reactions to diglycolamine was unequivocally proven by its presence in the MWF from the patients' workplace in 3 cases. Diglycolamine seems to be an important MWF allergen, independently from monoethanolamine and diethanolamine. A test concentration of 1% petrolatum (pet.) appears to be appropriate. The importance of AEPD and MDEA as MWF allergens still remains to be established. The lack of positive test reactions to the other MWF components tested may be due to their low-sensitizing potential or too low a patch test concentration being used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2003.00187.x
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  • 7
    Electronic Resource
    Electronic Resource
    Delayed-type hypersensitivity skin reactions due to heparins and heparinoids. Tolerance of recombinant hirudins and of the new synthetic anticoagulant fondaparinux (2003)
    Oxford, UK; Malden , USA : Munksgaard International Publishers
    Contact dermatitis 49 (2003), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Eczema-like, infiltrated plaques at subcutaneous heparin-injection sites are well-documented side effects of these anticoagulants. They are due to delayed-type hypersensitivity. In 4 patients, patch, intradermal and subcutaneous tests were performed with a panel of unfractionated heparins (UFHs), low-molecular-weight heparins (LMWHs), heparinoids, recombinant hirudins and a new synthetic pentasaccharide anticoagulant fondaparinux sodium, to find safe alternatives. 3 patients were sensitized to all the UFHs and LMWHs. The LMWH tinzaparin sodium and the heparinoid pentosan polysulfate were found to be a possible substitute in patient no. 1 and 2, respectively. The recombinant hirudins and fondaparinux sodium were tolerated without any side effects in all patients tested. Fondaparinux is a synthetic copy of a pentasaccharide sequence in the heparin molecule. It is the first in a new class of antithrombotic agents. Our study suggests that it is a new safe alternative in patients with eczema-like, infiltrated plaques at subcutaneous heparin-injection sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2003.0255.x
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  • 8
    Electronic Resource
    Electronic Resource
    Physicochemical Characteristics and Quality of Refrigerated Spanish Orange-Carrot Juices and Influence of Storage Conditions (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 68 (2003), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: : The effects of the physicochemical and quality characteristics of various refrigerated mixed orange and carrot juices, and their changes with storage time and temperature were investigated. Density, dry extract, Brix values, acidity, turbidity, formol index, pectinmethylesterase, hydroxymethylfurfural, essential oils, ascorbic acid, and color varied with storage time and temperature. Some of the parameters could be used as indicators of quality loss or spoilage of the juices. The degradation of ascorbic acid corresponded to 1st-order kinetics. The shelf life of the juices was established at 4 °C and 50-d storage or at 10 °C and 32-d storage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.2003.tb07028.x
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  • 9
    Electronic Resource
    Electronic Resource
    Knowledge management in consulting engineering - joining IT and human resources to support the production of knowledge (2003)
    Oxford : Emerald
    Engineering, construction and architectural management 10 (2003), S. 391-401 
    Details
    ISSN: 1365-232X
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Architecture, Civil Engineering, Surveying
    Notes: This article discusses how information technology and human resource oriented management tools can be integrated using their respective strengths to enable knowledge production. Two companies' KM strategies encompassing a strong IT-component in combination with organisation, training and office design are analysed. Their experience shows that joining information technology with the human resource oriented tools is a necessary precondition for success in KM-efforts. Second, in the large company, there is still a relative overemphasis on "circumstantial" frames for knowledge production and too little focus on dynamics in knowledge producing processes. In contrast, the medium sized company is experimenting with soft tools used directly in the processes of the customer-oriented projects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09699980310509363
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  • 10
    Electronic Resource
    Electronic Resource
    TQM: why is its impact in higher education so small? (2003)
    Bradford : Emerald
    The @TQM magazine 15 (2003), S. 325-333 
    Details
    ISSN: 0954-478X
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Despite still having many supporters and much use outside higher education, total quality management (TQM) has had a remarkably small impact on colleges and universities. While numerous institutions of higher education have sponsored "quality" initiatives, nearly all of these have focused on non-academic activities. Thus, higher education TQM has concentrated on processes such as registration, physical plant, bill paying, and purchasing. It has ignored the most critical questions facing the academy such as faculty tenure, curriculum, tuition and fee levels vis-à-vis scholarship assistance. TQM has had virtually nothing to say about these matters. Two-thirds of institutions that began TQM projects in the 1990s abandoned them because the vast majority have been failures. Why? Because TQM has failed to address the most important issues. Nor, because of the nature of academic culture and the difficulty of defining the precise nature of higher education, is it ever likely to do so. TQM's time has come and passed in higher education.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09544780310487721
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