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  • 1
    Electronic Resource
    Electronic Resource
    Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin (2000)
    Springer
    Colloid & polymer science 278 (2000), S. 1216-1219 
    Details
    ISSN: 1435-1536
    Keywords: Key words Chitosan ; Deoxycholic acid ; Self-aggregate ; Nanoparticle ; Adriamycin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering, fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregates, suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960000389
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  • 2
    Electronic Resource
    Electronic Resource
    Association of the vitamin D receptor start codon polymorphism (FokI) with bone mineral density in postmenopausal Korean women (2000)
    Springer
    Journal of human genetics 45 (2000), S. 280-283 
    Details
    ISSN: 1435-232X
    Keywords: Key words Bone mineral density ; FokI ; DNA polymorphism ; Vitamin D receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We undertook this study in order to examine the association between bone mineral density (BMD) and a polymorphism at the first of two potential translation initiation codons in the vitamin D receptor (VDR) gene. This polymorphism was detected by restriction fragment length polymorphism analysis, using polymerase chain reaction (PCR) and the restriction endonuclease FokI. The f allele indicates the presence of the FokI site, and the F allele its absence. The FokI genotype was determined in 174 postmenopausal Korean women, aged 43–71 years. The distribution of FokI genotypes in Koreans was found not to differ significantly from those found in Caucasians and Japanese, although it does differ significantly from that found in the black American population. We observed a significant association between the FokI polymorphism and lumbar BMD; P = 0.048, analysis of covariance [ANCOVA], but no association with femoral neck BMD (P = 0.505, ANCOVA). Those with the ff genotype had a 13.3% lower BMD in the lumbar spine than the FF subjects. In addition, a significantly higher prevalence of the ff genotype was observed in osteoporotic compared with osteopenic or normal women (P = 0.036, χ2 test). These data suggest that the ff genotype of the VDR gene correlates with decreased BMD in the lumbar spine in postmenopausal Korean women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380070016
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    Paper (German National Licenses)
    Fulltext
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